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Clinical problem-solving requires processing of semantic medical knowledge such as illness scripts and numerical medical knowledge of diagnostic tests for evidence-based decision-making. As large language models (LLMs) show promising…

Emergency management urgently requires comprehensive knowledge while having a high possibility to go beyond individuals' cognitive scope. Therefore, artificial intelligence(AI) supported decision-making under that circumstance is of vital…

Computation and Language · Computer Science 2023-11-16 Minze Chen , Zhenxiang Tao , Weitong Tang , Tingxin Qin , Rui Yang , Chunli Zhu

Due to the increasing adoption of electronic health records (EHR), large scale EHRs have become another rich data source for translational clinical research. Despite its potential, deriving generalizable knowledge from EHR data remains…

Machine Learning · Statistics 2023-06-01 Junwei Lu , Jin Yin , Tianxi Cai

Considering the inherent limitations of parametric knowledge in large language models (LLMs), retrieval-augmented generation (RAG) is widely employed to expand their knowledge scope. Since RAG has shown promise in knowledge-intensive tasks…

Computation and Language · Computer Science 2025-05-20 Yuhao Wang , Ruiyang Ren , Yucheng Wang , Wayne Xin Zhao , Jing Liu , Hua Wu , Haifeng Wang

Large Language Models (LLMs) have shown promise as robotic planners but often struggle with long-horizon and complex tasks, especially in specialized environments requiring external knowledge. While hierarchical planning and…

Artificial Intelligence · Computer Science 2025-04-08 Cristina Cornelio , Flavio Petruzzellis , Pietro Lio

Difficult decision-making problems abound in various disciplines and domains. The proliferation of generative techniques, especially large language models (LLMs), has excited interest in using them for decision support. However, LLMs cannot…

Artificial Intelligence · Computer Science 2025-09-16 Boris Kovalerchuk , Brent D. Fegley

Current medical retrieval-augmented generation (RAG) approaches overlook evidence-based medicine (EBM) principles, leading to two key gaps: (1) the lack of PICO alignment between queries and retrieved evidence, and (2) the absence of…

Computation and Language · Computer Science 2026-03-27 Jinning Zhang , Jie Song , Wenhui Tu , Zecheng Li , Jingxuan Li , Jin Li , Xuan Liu , Taole Sha , Zichen Wei , Yan Li

Unstructured data in Electronic Health Records (EHRs) often contains critical information -- complementary to imaging -- that could inform radiologists' diagnoses. But the large volume of notes often associated with patients together with…

Computation and Language · Computer Science 2024-06-12 Hiba Ahsan , Denis Jered McInerney , Jisoo Kim , Christopher Potter , Geoffrey Young , Silvio Amir , Byron C. Wallace

Incorporating external knowledge into dialogue generation (KIDG) is crucial for improving the correctness of response, where evidence fragments serve as knowledgeable snippets supporting the factual dialogue replies. However, introducing…

Computation and Language · Computer Science 2023-09-18 Xianjie Wu , Jian Yang , Tongliang Li , Di Liang , Shiwei Zhang , Yiyang Du , Zhoujun Li

Drug repurposing is often framed as a candidate identification task, but existing approaches provide limited guidance for distinguishing biologically plausible candidates from historically well-connected ones. Here we introduce DrugKLM, a…

Attribution and fact verification are critical challenges in natural language processing for assessing information reliability. While automated systems and Large Language Models (LLMs) aim to retrieve and select concise evidence to support…

Computation and Language · Computer Science 2026-01-30 Guy Alt , Eran Hirsch , Serwar Basch , Ido Dagan , Oren Glickman

Safe and trustworthy use of Large Language Models (LLM) in the processing of healthcare documents and scientific papers could substantially help clinicians, scientists and policymakers in overcoming information overload and focusing on the…

Large language models (LLMs) have recently emerged as powerful tools, finding many medical applications. LLMs' ability to coalesce vast amounts of information from many sources to generate a response-a process similar to that of a human…

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

To improve the reliability of Large Language Models (LLMs) in clinical applications, retrieval-augmented generation (RAG) is extensively applied to provide factual medical knowledge. However, beyond general medical knowledge from open-ended…

Computation and Language · Computer Science 2025-05-29 Justice Ou , Tinglin Huang , Yilun Zhao , Ziyang Yu , Peiqing Lu , Rex Ying

Retrieval-Augmented Generation (RAG) effectively improves the accuracy of Large Language Models (LLMs). However, retrieval noises significantly undermine the quality of LLMs' generation, necessitating the development of denoising…

Computation and Language · Computer Science 2026-04-21 Xinping Zhao , Shouzheng Huang , Yan Zhong , Xinshuo Hu , Meishan Zhang , Baotian Hu , Min Zhang

Large Language Models (LLMs) have achieved impressive capabilities in language understanding and generation, yet they continue to underperform on knowledge-intensive reasoning tasks due to limited access to structured context and multi-hop…

Computation and Language · Computer Science 2025-06-26 Travis Thompson , Seung-Hwan Lim , Paul Liu , Ruoying He , Dongkuan Xu

Large Language Models (LLMs) enhanced with retrieval -- commonly referred to as Retrieval-Augmented Generation (RAG) -- have demonstrated strong performance in knowledge-intensive tasks. However, RAG pipelines often fail when retrieved…

Computation and Language · Computer Science 2025-11-07 Shiyin Lin

Retrieval-Augmented Generation (RAG) integrates non-parametric knowledge into Large Language Models (LLMs), typically from unstructured texts and structured graphs. While recent progress has advanced text-based RAG to multi-turn reasoning…

Computation and Language · Computer Science 2025-12-11 Yucan Guo , Miao Su , Saiping Guan , Zihao Sun , Xiaolong Jin , Jiafeng Guo , Xueqi Cheng

Integrating large language models (LLMs) with knowledge graphs derived from domain-specific data represents an important advancement towards more powerful and factual reasoning. As these models grow more capable, it is crucial to enable…

Artificial Intelligence · Computer Science 2024-04-19 Stefan Dernbach , Khushbu Agarwal , Alejandro Zuniga , Michael Henry , Sutanay Choudhury