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When recording the movement of individual animals, cells or molecules one will often observe changes in their diffusive behaviour at certain points in time along their trajectory. In order to capture the different diffusive modes assembled…

Statistical Mechanics · Physics 2024-10-21 Henrik Seckler , Ralf Metzler

Change point detection has become an important part of the analysis of the single-particle tracking data, as it allows one to identify moments, in which the motion patterns of observed particles undergo significant changes. The segmentation…

Quantitative Methods · Quantitative Biology 2025-06-23 Jakub Malinowski , Marcin Kostrzewa , Michał Balcerek , Weronika Tomczuk , Janusz Szwabiński

Deviations from Brownian motion leading to anomalous diffusion are found in transport dynamics from quantum physics to life sciences. The characterization of anomalous diffusion from the measurement of an individual trajectory is a…

Understanding and identifying different types of single molecules' diffusion that occur in a broad range of systems (including living matter) is extremely important, as it can provide information on the physical and chemical characteristics…

Quantitative Methods · Quantitative Biology 2023-03-07 Patrycja Kowalek , Hanna Loch-Olszewska , Łukasz Łaszczuk , Jarosław Opała , Janusz Szwabiński

Biophysical processes within living systems rely on encounters and interactions between molecules in complex environments such as cells. They are often described by anomalous diffusion transport. Recent advances in single-molecule…

Data Analysis, Statistics and Probability · Physics 2025-02-27 Solomon Asghar , Ran Ni , Giorgio Volpe

Diffusion processes are important in several physical, chemical, biological and human phenomena. Examples include molecular encounters in reactions, cellular signalling, the foraging of animals, the spread of diseases, as well as trends in…

Data Analysis, Statistics and Probability · Physics 2021-06-21 Alessia Gentili , Giorgio Volpe

Anomalous diffusion occurs in a wide range of systems, including protein transport within cells, animal movement in complex habitats, pollutant dispersion in groundwater, and nanoparticle motion in synthetic materials. Accurately estimating…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Yusef Ahsini , Marc Escoto , J. Alberto Conejero

The study of the dynamics of natural and artificial systems has provided several examples of deviations from Brownian behavior, generally defined as anomalous diffusion. The investigation of these dynamics can provide a better understanding…

Data Analysis, Statistics and Probability · Physics 2025-08-29 Carlo Manzo

Heterogeneous dynamics commonly emerges in anomalous diffusion with intermittent transitions of diffusion states but proves challenging to identify using conventional statistical methods. To effectively capture these transient changes of…

Biological Physics · Physics 2024-01-24 Xiang Qu , Yi Hu , Wenjie Cai , Yang Xu , Hu Ke , Guolong Zhu , Zihan Huang

Anomalous diffusion occurs at very different scales in nature, from atomic systems to motions in cell organelles, biological tissues or ecology, and also in artificial materials, such as cement. Being able to accurately measure the…

Machine Learning · Computer Science 2021-08-09 Òscar Garibo i Orts , Miguel A. Garcia-March , J. Alberto Conejero

Modern single-particle-tracking techniques produce extensive time-series of diffusive motion in a wide variety of systems, from single-molecule motion in living-cells to movement ecology. The quest is to decipher the physical mechanisms…

Statistical Mechanics · Physics 2023-09-14 Henrik Seckler , Ralf Metzler

The deviation from pure Brownian motion generally referred to as anomalous diffusion has received large attention in the scientific literature to describe many physical scenarios. Several methods, based on classical statistics and machine…

Single-particle tracking allows to infer the motion of single molecules in living cells. When we observe a long trajectory (more than 100 points), it is possible that the particle switches mode of motion over time. Then, fitting a single…

Methodology · Statistics 2018-04-16 Vincent Briane , Charles Kervrann , Myriam Vimond

Single-particle traces of the diffusive motion of molecules, cells, or animals are by-now routinely measured, similar to stochastic records of stock prices or weather data. Deciphering the stochastic mechanism behind the recorded dynamics…

Statistical Mechanics · Physics 2023-09-14 Henrik Seckler , Janusz Szwabinski , Ralf Metzler

Diffusive dynamics abound in nature and have been especially studied in physical, biological, and financial systems. These dynamics are characterised by a linear growth of the mean squared displacement (MSD) with time. Often, the conditions…

Statistical Mechanics · Physics 2025-11-14 Alvaro Lanza , Xiang Qu , Stefano Bo

The rapid advancements in machine learning have made its application to anomalous diffusion analysis both essential and inevitable. This review systematically introduces the integration of machine learning techniques for enhanced analysis…

Machine Learning · Computer Science 2025-04-01 Wenjie Cai , Yi Hu , Xiang Qu , Hui Zhao , Gongyi Wang , Jing Li , Zihan Huang

Anomalous diffusion, which shows a deviation of transport dynamics from the framework of standard Brownian motion, is involved in the evolution of various physical, chemical, biological, and economic systems. The study of such random…

Machine Learning · Computer Science 2021-09-21 Dezhong Li , Qiujin Yao , Zihan Huang

Countless systems in biology, physics, and finance undergo diffusive dynamics. Many of these systems, including biomolecules inside cells, active matter systems and foraging animals, exhibit anomalous dynamics where the growth of the mean…

Statistical Mechanics · Physics 2021-08-11 Aykut Argun , Giovanni Volpe , Stefano Bo

Anomalous diffusion is present at all scales, from atomic to large scales. Some exemplary systems are; ultra-cold atoms, telomeres in the nucleus of cells, moisture transport in cement-based materials, the free movement of arthropods, and…

Image and Video Processing · Electrical Eng. & Systems 2023-10-04 Òscar Garibo-i-Orts , Nicolás Firbas , Laura Sebastiá , J. Alberto Conejero

In order to characterize the mechanisms governing the diffusion of particles in biological scenarios, it is essential to accurately determine their diffusive properties. To do so, we propose a machine learning method to characterize…

Soft Condensed Matter · Physics 2023-11-29 Borja Requena , Sergi Masó , Joan Bertran , Maciej Lewenstein , Carlo Manzo , Gorka Muñoz-Gil
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