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The recent advances in cancer immunotherapy boosted the development of tumor-immune system models aiming to provide mechanistic understanding and indicate more efficient treatment regimes. However, the complexity of such models, their…

Dynamical Systems · Mathematics 2023-09-18 Dimitrios G. Patsatzis

We present an asymptotic preserving scheme based on a micro-macro decomposition for stochastic linear transport equations in kinetic and diffusive regimes. We perfom a mathematical analysis and prove that the scheme is uniformly stable with…

Numerical Analysis · Mathematics 2018-03-19 Nathalie Ayi , Erwan Faou

An asymptotic-preserving (AP) implicit-explicit PN numerical scheme is proposed for the gray model of the radiative transfer equation, where the first- and second-order numerical schemes are discussed for both the linear and nonlinear…

Numerical Analysis · Mathematics 2024-11-01 Jinxue Fu , Juan Cheng , Weiming Li , Tao Xiong , Yanli Wang

We develop and study an asymptotic-preserving (AP) numerical scheme for a linear kinetic equation in a large deviation regime. After applying a Hopf-Cole transform to the distribution function, the system exhibits the behavior of rare…

Numerical Analysis · Mathematics 2025-09-15 Hélène Hivert , Tino Laidin

Tumor growth has long been a target of investigation within the context of mathematical and computer modelling. The objective of this study is to propose and analyze a two-dimensional probabilistic cellular automata model to describe…

Tissues and Organs · Quantitative Biology 2009-11-13 E. A. Reis , L. B. L. Santos , S. T. R. Pinho

Gaseous flows show a diverse set of behaviors on different characteristic scales. Given the coarse-grained modeling in theories of fluids, considerable uncertainties may exist between the flow-field solutions and the real physics. To study…

Computational Physics · Physics 2021-05-05 Tianbai Xiao , Martin Frank

We apply the concept of Asymptotic Preserving (AP) schemes to the linearized p-system and discretize the resulting elliptic equation using standard continuous Finite Elements instead of Finite Differences. The fully discrete method is…

Numerical Analysis · Mathematics 2014-06-17 Jochen Schütz

Wave propagation problems for heterogeneous media are known to have many applications in physics and engineering. Recently, there has been an increasing interest in stochastic effects due to the uncertainty, which may arise from impurities…

Numerical Analysis · Mathematics 2019-02-20 Ching-Shan Chou , Yukun Li , Dongbin Xiu

In this paper, we develop and implement an efficient asymptotic-preserving (AP) scheme to solve the gas mixture of Boltzmann equations under the disparate mass scaling relevant to the so-called "epochal relaxation" phenomenon. The disparity…

Numerical Analysis · Mathematics 2025-07-11 Zhen Hao , Ning Jiang , Liu Liu

Understanding the untreated tumor growth kinetics and its intrinsic findings is interesting and intriguing. The aim of this study is to propose an approximate analytical expression that allows to simulate changes in surface charge density…

The main purpose of the present paper is to study from a numerical analysis point of view some robust methods designed to cope with stiff (highly anisotropic) elliptic problems. The so-called asymptotic-preserving schemes studied in this…

Numerical Analysis · Mathematics 2015-07-06 Alexei Lozinski , Jacek Narski , Claudia Negulescu

Strong experimental evidence has indicated that tumor growth belongs to the molecular beam epitaxy universality class. This type of growth is characterized by the constraint of cell proliferation to the tumor border, and surface diffusion…

Quantitative Methods · Quantitative Biology 2009-11-13 Carlos Escudero

In this paper we study asymptotic behavior of solutions for a free boundary problem modeling the growth of tumors containing two species of cells: proliferating cells and quiescent cells. This tumor model was proposed by Pettet et al in…

Analysis of PDEs · Mathematics 2007-12-18 Shangbin Cui

Cancer poses danger because of its unregulated growth, development of resistant subclones, and metastatic spread to vital organs. Although the major transitions in cancer development are increasingly well understood, we lack quantitative…

Populations and Evolution · Quantitative Biology 2014-08-27 Andrei R. Akhmetzhanov , Michael E. Hochberg

In this paper, we study an asymptotic preserving (AP), energy stable and positivity preserving semi-implicit finite volume scheme for the Euler-Poisson-Boltzmann (EPB) system in the quasineutral limit. The key to energy stability is the…

Numerical Analysis · Mathematics 2024-08-16 K. R. Arun , R. Ghorai

We investigate the linear stability analysis of a pathway-based diffusion model (PBDM), which characterizes the dynamics of the engineered Escherichia coli populations [X. Xue and C. Xue and M. Tang, P LoS Computational Biology, 14 (2018),…

Numerical Analysis · Mathematics 2023-04-03 Yaming Zhang , Ning Jiang , Jiangyan Liang , Yi-Long Luo , Min Tang

We develop an asymptotic-preserving scheme to solve evolution problems containing stiff transport terms. This scheme is based to a micro-macro decomposition of the unknown, coupled with a stabilization procedure. The numerical method is…

Numerical Analysis · Mathematics 2018-02-21 Baptiste Fedele , Claudia Negulescu , Stefan Possanner

Tumor-immune interactions are central to cancer progression and treatment outcomes. In this study, we present a stochastic agent-based model that integrates cellular heterogeneity, spatial cell-cell interactions, and drug resistance…

Tissues and Organs · Quantitative Biology 2026-05-19 Yuhong Zhang , Chenghang Li , Boya Wang , Jinzhi Lei

We investigate avascular tumour growth as a two-phase process consisting of cells and liquid. Based on the one-dimensional continuum moving-boundary model formulated by (Byrne, King, McElwain, Preziosi, Applied Mathematics Letters, 2003,…

Analysis of PDEs · Mathematics 2020-06-24 Andrea Genovese de Oliveira , John R. King

The unified gas kinetic scheme (UGKS) of K. Xu et al. [K. Xu and J.-C. Huang, J. Comput. Phys., 229, pp. 7747--7764, 2010], originally developed for multiscale gas dynamics problems, is applied in this paper to a linear kinetic model of…

Numerical Analysis · Mathematics 2014-01-24 Luc Mieussens