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Accurate epidemic forecasting is crucial for outbreak preparedness, but existing data-driven models are often brittle. Typically trained on a single pathogen, they struggle with data scarcity during new outbreaks and fail under distribution…

Machine Learning · Computer Science 2026-02-25 Zewen Liu , Juntong Ni , Bohan Wang , Max S. Y. Lau , Wei Jin

We develop a mesoscopic modeling framework for diffusion in a crowded environment, particularly targeting applications in the modeling of living cells. Through homogenization techniques we effectively coarse-grain a detailed microscopic…

Subcellular Processes · Quantitative Biology 2018-09-19 Stefan Engblom , Per Lötstedt , Lina Meinecke

Accounting for the complexity of psychological theories requires methods that can predict not only changes in the means of latent variables -- such as personality factors, creativity, or intelligence -- but also changes in their variances.…

Methodology · Statistics 2025-05-27 Luna Fazio , Paul-Christian Bürkner

Macro-level modeling is still the dominant approach in many demographic applications because of its simplicity. Individual-level models, on the other hand, provide a more comprehensive understanding of observed patterns; however, their…

Applications · Statistics 2023-12-14 Daniel Ciganda , Nicolas Todd

Many epidemic models are naturally defined as individual-based models: where we track the state of each individual within a susceptible population. Inference for individual-based models is challenging due to the high-dimensional state-space…

Methodology · Statistics 2025-08-04 Lorenzo Rimella , Christopher Jewell , Paul Fearnhead

Collective cell migration plays a crucial role in numerous biological processes, including tumour growth, wound healing, and the immune response. Often, the migrating population consists of cells with various different phenotypes. This…

Populations and Evolution · Quantitative Biology 2025-04-01 Rebecca M. Crossley , Philip K. Maini , Ruth E. Baker

The first chapter concerns monotype population models. We first study general birth and death processes and we give non-explosion and extinction criteria, moment computations and a pathwise representation. We then show how different scales…

Probability · Mathematics 2017-07-06 Vincent Bansaye , Sylvie Méléard

Populations of heterogeneous cells play an important role in many biological systems. In this paper we consider systems where each cell can be modelled by an ordinary differential equation. To account for heterogeneity, parameter values are…

Quantitative Methods · Quantitative Biology 2009-09-27 Steffen Waldherr , Jan Hasenauer , Frank Allgöwer

Recent years have seen a large amount of interest in epidemics on networks as a way of representing the complex structure of contacts capable of spreading infections through the modern human population. The configuration model is a popular…

Populations and Evolution · Quantitative Biology 2017-01-23 Frank Ball , Thomas House

Mathematical models of infectious diseases, which are in principle analytically tractable, use two general approaches. The first approach, generally known as compartmental modeling, addresses the time evolution of disease propagation at the…

Populations and Evolution · Quantitative Biology 2010-09-16 Pierre-André Noël , Bahman Davoudi , Robert C. Brunham , Louis J. Dubé , Babak Pourbohloul

Whole genome sequencing of pathogens from multiple hosts in an epidemic offers the potential to investigate who infected whom with unparalleled resolution, potentially yielding important insights into disease dynamics and the impact of…

Renewal models are widely used in statistical epidemiology as semi-mechanistic models of disease transmission. While primarily used for estimating the instantaneous reproduction number, they can also be used for generating projections,…

Methodology · Statistics 2025-09-25 Nicholas Steyn , Kris V. Parag , Robin N. Thompson , Christl A. Donnelly

Traditional disease transmission models assume that the infectious period is exponentially distributed with a recovery rate fixed in time and across individuals. This assumption provides analytical and computational advantages, however it…

Populations and Evolution · Quantitative Biology 2024-01-30 Laura Di Domenico , Eugenio Valdano , Vittoria Colizza

We consider the edge-based compartmental models for infectious disease spread introduced in Part I. These models allow us to consider standard SIR diseases spreading in random populations. In this paper we show how to handle deviations of…

Populations and Evolution · Quantitative Biology 2015-09-03 Joel C. Miller , Erik M. Volz

It is essential to understand the dynamics of epidemics in the presence of coexisting pathogens. There are various phenomenon that can effect the dynamics. In this paper, we formulate a mathematical model using different assumptions to…

Populations and Evolution · Quantitative Biology 2021-11-02 S. Ghersheen , V. Kozlov , U. Wennergren

This paper is a survey paper on stochastic epidemic models. A simple stochastic epidemic model is defined and exact and asymptotic model properties (relying on a large community) are presented. The purpose of modelling is illustrated by…

Probability · Mathematics 2009-11-05 Tom Britton

We investigate a model for spatial epidemics explicitly taking into account bi-directional movements between base and destination locations on individual mobility networks. We provide a systematic analysis of generic dynamical features of…

Physics and Society · Physics 2012-03-07 Vitaly Belik , Theo Geisel , Dirk Brockmann

Metapopulation models are commonly used in ecology, evolution, and epidemiology. These models usually entail homogeneity assumptions within patches and study networks of migration between patches to generate insights into conservation of…

Populations and Evolution · Quantitative Biology 2025-06-06 Diepreye Ayabina , Hasan Sevil , Adam Kleczkowski , M. Gabriela M. Gomes

Understanding infectious disease spread remains a critical public health challenge, particularly given the interplay between household dynamics and community transmission patterns. Traditional epidemiological models often oversimplify these…

Populations and Evolution · Quantitative Biology 2026-01-21 Houda Yaqine , Christiane Fuchs

We consider multiple diseases spreading in a static Configuration Model network. We make standard assumptions that infection transmits from neighbor to neighbor at a disease-specific rate and infected individuals recover at a…

Populations and Evolution · Quantitative Biology 2015-06-11 Joel C. Miller
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