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Multiple Instance Learning (MIL) is a sub-domain of classification problems with positive and negative labels and a "bag" of inputs, where the label is positive if and only if a positive element is contained within the bag, and otherwise is…

In computational cytology, detecting malignancy on whole-slide images is difficult because malignant cells are morphologically diverse yet vanishingly rare amid a vast background of normal cells. Accurate detection of these extremely rare…

Multi-instance learning (MIL) deals with objects represented as bags of instances and can predict instance labels from bag-level supervision. However, significant performance gaps exist between instance-level MIL algorithms and supervised…

While Large Language Models (LLMs) are emerging as a promising direction in computational pathology, the substantial computational cost of giga-pixel Whole Slide Images (WSIs) necessitates the use of Multi-Instance Learning (MIL) to enable…

Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

Whole body magnetic resonance imaging (WB-MRI) is the recommended modality for diagnosis of multiple myeloma (MM). WB-MRI is used to detect sites of disease across the entire skeletal system, but it requires significant expertise and is…

We consider machine-learning-based thyroid-malignancy prediction from cytopathology whole-slide images (WSI). Multiple instance learning (MIL) approaches, typically used for the analysis of WSIs, divide the image (bag) into patches…

Multiple instance learning (MIL) is an effective and widely used approach for weakly supervised machine learning. In histopathology, MIL models have achieved remarkable success in tasks like tumor detection, biomarker prediction, and…

Whole slide image (WSI) classification is a critical task in computational pathology, requiring the processing of gigapixel-sized images, which is challenging for current deep-learning methods. Current state of the art methods are based on…

In digital pathology, Whole Slide Image (WSI) analysis is usually formulated as a Multiple Instance Learning (MIL) problem. Although transformer-based architectures have been used for WSI classification, these methods require modifications…

We apply deep learning (DL) on Magnetic resonance spectroscopy (MRS) data for the task of brain tumor detection. Medical applications often suffer from data scarcity and corruption by noise. Both of these problems are prominent in our data…

Computational pathology involves the digitization of stained tissues into whole-slide images (WSIs) that contain billions of pixels arranged as contiguous patches. Statistical analysis of WSIs largely focuses on classification via multiple…

Treatment approaches for colorectal cancer (CRC) are highly dependent on the molecular subtype, as immunotherapy has shown efficacy in cases with microsatellite instability (MSI) but is ineffective for the microsatellite stable (MSS)…

Multiple Instance Learning (MIL) is widely used in medical imaging classification to reduce the labeling effort. While only bag labels are available for training, one typically seeks predictions at both bag and instance levels…

Deep learning based computer vision fails to work when labeled images are scarce. Recently, Meta learning algorithm has been confirmed as a promising way to improve the ability of learning from few images for computer vision. However,…

The dynamic nature of open-world scenarios has attracted more attention to class incremental learning (CIL). However, existing CIL methods typically presume the availability of complete ground-truth labels throughout the training process,…

The survival analysis on histological whole-slide images (WSIs) is one of the most important means to estimate patient prognosis. Although many weakly-supervised deep learning models have been developed for gigapixel WSIs, their potential…

When supervising an object detector with weakly labeled data, most existing approaches are prone to trapping in the discriminative object parts, e.g., finding the face of a cat instead of the full body, due to lacking the supervision on the…

Detecting anomalies over real-world datasets remains a challenging task. Data annotation is an intensive human labor problem, particularly in sequential datasets, where the start and end time of anomalies are not known. As a result, data…

Aortic stenosis (AS) is a degenerative valve condition that causes substantial morbidity and mortality. This condition is under-diagnosed and under-treated. In clinical practice, AS is diagnosed with expert review of transthoracic…