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The main purpose of this paper is to study the local dynamics and bifurcations of a discrete-time SIR epidemiological model. The existence and stability of disease-free and endemic fixed points are investigated along with a fairly complete…

Dynamical Systems · Mathematics 2021-08-05 Johan Hallberg Szabadváry , Yishao Zhou

The propagation of infectious diseases and its impact on individuals play a major role in disease dynamics, and it is important to incorporate population heterogeneity into efforts to study diseases. As a simplistic but illustrative…

Populations and Evolution · Quantitative Biology 2019-07-24 Juan G. Calvo , Alberto Hernández , Mason A. Porter , Fabio Sanchez

We will study a mathematical model of the human immunodeficiency virus (HIV) infection in the presence of combination therapy that includes within-host infectious dynamics. The deterministic model requires us to analyze asymptotic stability…

Populations and Evolution · Quantitative Biology 2017-09-04 Majid Jaberi Douraki

Multiple viruses are widely studied because of their negative effect on the health of host as well as on whole population. The dynamics of coinfection is important in this case. We formulated a SIR model that describes the coinfection of…

Dynamical Systems · Mathematics 2019-05-14 Samia Ghersheen , Vladimir Kozlov , Vladimir G. Tkachev , Uno Wennergren

In this study, we develop and analyze a nested multi-scale model for COVID -19 disease that integrates within-host scale and between-host scale sub-models. First, the well-posedness of the multi-scale model is discussed, followed by the…

Dynamical Systems · Mathematics 2021-08-30 Bishal Chhetri , D. K. K Vamsi , Carani Sanjeevi

There has been interest in the interactions between infectious disease dynamics and behaviour for most of the history of mathematical epidemiology. This has included consideration of which mathematical models best capture each phenomenon,…

Populations and Evolution · Quantitative Biology 2025-12-09 Matthew Ryan , Roslyn I. Hickson , Edward M. Hill , Thomas House , Valerie Isham , Dongni Zhang , Mick G. Roberts

This research investigates the coupled dynamics of behavior and infectious disease using a mathematical model. We integrate a two-state q-voter opinion process with SIS-type infection dynamics, where transmission rates are influenced by the…

Physics and Society · Physics 2025-12-13 Thomas Goetz , Tyll Krueger , Karol Niedzielewski , Jan Schneider , Barbara Pabjan

We consider the SIRWJS epidemiological model that includes the waning and boosting of immunity via secondary infections. We carry out combined analytical and numerical investigations of the dynamics. The formulae describing the existence…

Populations and Evolution · Quantitative Biology 2023-05-16 Richmond Opoku-Sarkodie , Ferenc A. Bartha , Mónika Polner , Gergely Röst

Decline of immunity is a phenomenon characterized by immunocompromised host and plays a crucial role in the epidemiology of emerging infectious diseases (EIDs) such as COVID-19. In this paper, we propose an age-structured model with…

Dynamical Systems · Mathematics 2024-07-23 Shuanglin Jing , Ling Xue , Jichen Yang

The role of cooperative effects (i.e. synergy) in transmission of infection is investigated analytically and numerically for epidemics following the rules of Susceptible-Infected-Susceptible (SIS) model defined on random regular graphs.…

Physics and Society · Physics 2019-04-03 Sergei N. Taraskin , Francisco J. Pérez-Reche

Transmission dynamics of infectious diseases are often studied using compartmental mathematical models, which are commonly represented as systems of autonomous ordinary differential equations. A key step in the analysis of such models is to…

Populations and Evolution · Quantitative Biology 2025-12-15 David J. D. Earn , C. Connell McCluskey

Infectious disease transmission in human populations has a complex two-way interaction with changes in host behaviour. It is increasingly recognised that incorporating adaptive behavioural change into epidemic models is important for…

Populations and Evolution · Quantitative Biology 2026-04-14 Michael J. Plank , Matt Ryan , Lloyd Chapman , Roslyn I. Hickson , Thomas House , Emma McBryde , James M. McCaw

Many infectious diseases are comprised of multiple strains with examples including Influenza, tuberculosis, and Dengue virus. The time evolution of such systems is linked to a complex landscape shaped by interactions between competing…

Populations and Evolution · Quantitative Biology 2023-11-21 Nir Gavish , Musa Rabiu

Mathematical modelling of epidemiological and coevolutionary dynamics is widely being used to improve disease management strategies of infectious diseases. Many diseases present some form of intra-host quiescent stage, also known as covert…

Populations and Evolution · Quantitative Biology 2022-05-26 Usman Sanusi , Sona John , Johannes Mueller , Aurélien Tellier

When an infectious disease propagates throughout society, the incidence function may rise at first due to an increase in pathogenicity and then decrease due to inhibitory effects until it reaches saturation. Effective vaccination and…

Dynamical Systems · Mathematics 2023-07-11 Sushil Pathak , G. Shirisha , K. Venkata Ratnam

This paper studies a networked bivirus model, in which two competing viruses spread across a network of interconnected populations; each node represents a population with a large number of individuals. The viruses may spread through…

Dynamical Systems · Mathematics 2024-10-24 Mengbin Ye , Brian D. O. Anderson , Ji Liu

We study the Bazykin predator-prey model with predator intraspecific interactions and ratio-dependent functional response and show the existence and stability of two interior equilibrium points. We prove that the model displays a wide range…

Dynamical Systems · Mathematics 2021-03-08 Claudio Arancibia-Ibarra , Pablo Aguirre , José Flores , Peter van Heijster

Recently, Wang and Xu [ Appl. Math. Lett. 78 (2018) 105-111] studied thresholds and bi-stability in virus-immune dynamics. In this paper, we show there also exist backward bifurcation and saddle node bifurcation in this model. Our…

Populations and Evolution · Quantitative Biology 2022-01-03 Tengfei Wang , Shaoli Wang , Fei Xu

In mathematical studies of the dynamics of multi-strain diseases caused by antigenically diverse pathogens, there is a substantial interest in analytical insights. Using the example of a generic model of multi-strain diseases with…

Chaotic Dynamics · Physics 2015-11-13 K. B. Blyuss

In this research, we have derived a mathematical model for within human dynamics of COVID-19 infection using delay differential equations. The new model considers a 'latent period' and 'the time for immune response' as delay parameters,…

Populations and Evolution · Quantitative Biology 2025-01-14 Amar N. Chatterjee , Teklebirhan Abraha , Fahad Al Basir , Delfim F. M. Torres