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Quantum computing has recently exhibited great potentials in predicting chemical properties for various applications in drug discovery, material design, and catalyst optimization. Progress has been made in simulating small molecules, such…

Quantum kernel methods offer significant theoretical benefits by rendering classically inseparable features separable in quantum space. Yet, the practical application of Quantum Machine Learning (QML), currently constrained by the…

Machine Learning · Computer Science 2026-02-03 Philipp Altmann , Maximilian Mansky , Maximilian Zorn , Jonas Stein , Claudia Linnhoff-Popien

Quantum computing promises to tackle technological and industrial problems insurmountable for classical computers. However, today's quantum computers still have limited demonstrable functionality, and it is expected that scaling up to…

The development of quantum computers has been the stimulus that enables the realization of Quantum Machine Learning (QML), an area that integrates the calculational framework of quantum mechanics with the adaptive properties of classical…

Computational Engineering, Finance, and Science · Computer Science 2025-09-04 Bhavna Bose , Saurav Verma

Binding energy is a fundamental thermodynamic property that governs molecular interactions, playing a crucial role in fields such as healthcare and the natural sciences. It is particularly relevant in drug development, vaccine design, and…

Quantum Physics · Physics 2025-08-06 Erico Souza Teixeira , Lucas Barros Fernandes , Yara Rodrigues Inácio

Modern cyberattacks are increasingly complex, posing significant challenges to classical machine learning methods, particularly when labeled data is limited and feature interactions are highly non-linear. In this study we investigates the…

Cryptography and Security · Computer Science 2026-01-06 Jessica A. Sciammarelli , Waqas Ahmed

The basic idea of quantum computing is surprisingly similar to that of kernel methods in machine learning, namely to efficiently perform computations in an intractably large Hilbert space. In this paper we explore some theoretical…

Quantum Physics · Physics 2019-02-06 Maria Schuld , Nathan Killoran

Interest in quantum machine learning is increasingly growing due to its potential to offer more efficient solutions for problems that are difficult to tackle with classical methods. In this context, the research work presented here focuses…

Quantum Physics · Physics 2025-04-11 A. De Lorenzis , M. P. Casado , M. P. Estarellas , N. Lo Gullo , T. Lux , F. Plastina , A. Riera , J. Settino

Over the last century, a large number of physical and mathematical developments paired with rapidly advancing technology have allowed the field of quantum chemistry to advance dramatically. However, the lack of computationally efficient…

Quantum Physics · Physics 2011-03-08 James D. Whitfield , Jacob Biamonte , Alán Aspuru-Guzik

Ensemble methods in machine learning aim to improve prediction accuracy by combining multiple models. This is achieved by ensuring diversity among predictors to capture different data aspects. Homogeneous ensembles use identical models,…

Quantum Physics · Physics 2025-11-04 Emiliano Tolotti , Enrico Blanzieri , Davide Pastorello

Accurate prediction of residue-level pKa values is essential for understanding protein function, stability, and reactivity. While existing resources such as DeepKaDB and CpHMD-derived datasets provide valuable training data, their…

Chemical Physics · Physics 2026-03-13 Van Le , Tan Le

Current quantum systems have significant limitations affecting the processing of large datasets with high dimensionality, typical of high energy physics. In the present paper, feature and data prototype selection techniques were studied to…

High Energy Physics - Phenomenology · Physics 2023-12-18 Miguel Caçador Peixoto , Nuno Filipe Castro , Miguel Crispim Romão , Maria Gabriela Jordão Oliveira , Inês Ochoa

We develop a quantum embedding method that enables accurate and efficient treatment of interactions between molecules and an environment, while explicitly including many-body correlations. The molecule is composed of classical nuclei and…

Chemical Physics · Physics 2023-03-30 Matej Ditte , Matteo Barborini , Leonardo Medrano Sandonas , Alexandre Tkatchenko

Quantum annealing has shown significant potential as an approach to near-term quantum computing. Despite promising progress towards obtaining a quantum speedup, quantum annealers are limited by the need to embed problem instances within the…

Data Structures and Algorithms · Computer Science 2018-07-31 Alastair A. Abbott , Cristian S. Calude , Michael J. Dinneen , Richard Hua

Machine-learning models in chemistry - when based on descriptors of atoms embedded within molecules - face essential challenges in transferring the quality of predictions of local electronic structures and their associated properties across…

Chemical Physics · Physics 2024-09-27 Frederik Ø. Kjeldal , Janus J. Eriksen

This research explores the integration of quantum data embedding techniques into classical machine learning (ML) algorithms, aiming to assess the performance enhancements and computational implications across a spectrum of models. We…

Quantum Physics · Physics 2023-11-20 Minati Rath , Hema Date

Quantum embedding is an appealing route to fragment a large interacting quantum system into several smaller auxiliary `cluster' problems to exploit the locality of the correlated physics. In this work we critically review approaches to…

Strongly Correlated Electrons · Physics 2023-07-19 Max Nusspickel , Basil Ibrahim , George H. Booth

In the NISQ (Noisy intermediate-scale quantum) area, Quantum computers can be utilized for deep learning by treating variational quantum circuits as neural network models. This can be achieved by first encoding the input data onto quantum…

High Energy Physics - Phenomenology · Physics 2023-11-29 A. Hammad , Kyoungchul Kong , Myeonghun Park , Soyoung Shim

A long-standing goal of science is to accurately solve the Schr\"odinger equation for large molecular systems. The poor scaling of current quantum chemistry algorithms on classical computers imposes an effective limit of about a few dozen…

Chemical Physics · Physics 2022-02-11 Joshua A. Rackers , Lucas Tecot , Mario Geiger , Tess E. Smidt

Quantum embedding with transformers is a novel and promising architecture for quantum machine learning to deliver exceptional capability on near-term devices or simulators. The research incorporated a vision transformer (ViT) to advance…

Quantum Physics · Physics 2024-02-21 Hao-Yuan Chen , Yen-Jui Chang , Shih-Wei Liao , Ching-Ray Chang