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Quantum computational chemistry holds great promise for simulating molecular systems more efficiently than classical methods by leveraging quantum bits to represent molecular wavefunctions. However, current implementations face significant…

Quantum Physics · Physics 2025-09-10 Weitang Li , Shi-Xin Zhang , Zirui Sheng , Cunxi Gong , Jianpeng Chen , Zhigang Shuai

One of the main challenges in drug discovery is to find molecules that bind specifically and strongly to their target protein while having minimal binding to other proteins. By predicting binding affinity, it is possible to identify the…

Quantum Physics · Physics 2023-01-19 L. Domingo , M. Djukic , C. Johnson , F. Borondo

Hybrid quantum-classical neural networks represent a promising frontier in the search for improved machine learning models. This thesis explores the integration of quantum layers within classical convolutional neural network architectures,…

Quantum Physics · Physics 2025-07-18 Silvie Illésová

The field of quantum machine learning is a promising way to lead to a revolution in intelligent data processing methods. In this way, a hybrid learning method based on classic kernel methods is proposed. This proposal also requires the…

Quantum Physics · Physics 2024-11-01 Jhordan Silveira de Borba , Jonas Maziero

Despite rapid recent progress towards the development of quantum computers capable of providing computational advantages over classical computers, it seems likely that such computers will, initially at least, be required to run in a hybrid…

Data Structures and Algorithms · Computer Science 2020-01-27 Alastair A. Abbott , Cristian S. Calude , Michael J. Dinneen , Richard Hua

This work focuses on the limitations about the insufficient fitting capability of current quantum machine learning methods, which results from the over-reliance on a single data embedding strategy. We propose a novel quantum machine…

Quantum Physics · Physics 2025-04-01 Siyu Han , Lihan Jia , Lanzhe Guo

The advent of hybrid computing platforms consisting of quantum processing units integrated with conventional high-performance computing brings new opportunities for algorithm design. By strategically offloading select portions of the…

Quantum metrology plays a fundamental role in many scientific areas. However, the complexity of engineering entangled probes and the external noise raise technological barriers for realizing the expected precision of the to-be-estimated…

Quantum Physics · Physics 2021-01-21 Xiaodong Yang , Xi Chen , Jun Li , Xinhua Peng , Raymond Laflamme

In structure-based virtual screening, it is often necessary to evaluate the binding free energy of protein-ligand complexes by considering not only molecular conformations but also how these structures shift and rotate in space. The number…

Quantum Physics · Physics 2025-07-25 Pei-Kun Yang

Quantum machine learning has the potential to provide powerful algorithms for artificial intelligence. The pursuit of quantum advantage in quantum machine learning is an active area of research. For current noisy, intermediate-scale quantum…

Quantum Physics · Physics 2023-05-11 Rui Yang , Samuel Bosch , Bobak Kiani , Seth Lloyd , Adrian Lupascu

Quantum machine learning is a rapidly growing field at the intersection of quantum technology and artificial intelligence. This review provides a two-fold overview of several key approaches that can offer advancements in both the…

Quantum Physics · Physics 2023-03-07 Alexey Melnikov , Mohammad Kordzanganeh , Alexander Alodjants , Ray-Kuang Lee

We explore the potential application of quantum annealing to address the protein structure problem. To this end, we compare several proposed ab initio protein folding models for quantum computers and analyze their scaling and performance…

Quantum Physics · Physics 2026-04-27 Timon Scheiber , Matthias Heller , Andreas Giebel

Quantum machine learning has the potential for a transformative impact across industry sectors and in particular in finance. In our work we look at the problem of hedging where deep reinforcement learning offers a powerful framework for…

Embedded quantum machine learning (EQML) seeks to bring quantum machine learning (QML) capabilities to resource-constrained edge platforms such as IoT nodes, wearables, drones, and cyber-physical controllers. In 2026, EQML is technically…

Machine Learning · Computer Science 2026-03-16 Somdip Dey , Syed Muhammad Raza

Machine learning advances chemistry and materials science by enabling large-scale exploration of chemical space based on quantum chemical calculations. While these models supply fast and accurate predictions of atomistic chemical…

Chemical Physics · Physics 2019-06-25 K. T. Schütt , M. Gastegger , A. Tkatchenko , K. -R. Müller , R. J. Maurer

Free energy calculations are at the heart of physics-based analyses of biochemical processes. They allow us to quantify molecular recognition mechanisms, which determine a wide range of biological phenomena from how cells send and receive…

Kernel methods are powerful for machine learning, as they can represent data in feature spaces that similarities between samples may be faithfully captured. Recently, it is realized that machine learning enhanced by quantum computing is…

Quantum Physics · Physics 2023-08-22 Long Hin Li , Dan-Bo Zhang , Z. D. Wang

The field of drug discovery hinges on the accurate prediction of binding affinity between prospective drug molecules and target proteins, especially when such proteins directly influence disease progression. However, estimating binding…

Quantum computers have a potential for solving quantum chemistry problems with higher accuracy than classical computers. Quantum computing quantum Monte Carlo (QC-QMC) is a QMC with a trial state prepared in quantum circuit, which is…

Quantum Physics · Physics 2024-06-07 Shu Kanno , Hajime Nakamura , Takao Kobayashi , Shigeki Gocho , Miho Hatanaka , Naoki Yamamoto , Qi Gao

In the near future, material and drug design may be aided by quantum computer assisted simulations. These have the potential to target chemical systems intractable by the most powerful classical computers. However, the resources offered by…