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Aortic shape analysis plays a key role in cardiovascular diagnostics, treatment planning, and understanding disease progression. We present a robust, fully automated pipeline for aortic shape analysis from cardiac MRI, combining deep…

Tissues and Organs · Quantitative Biology 2025-09-15 Nairouz Shehata , Amr Elsawy , Mohamed Nagy , Muhammad ElMahdy , Mariam Ali , Soha Romeih , Heba Aguib , Magdi Yacoub , Ben Glocker

Spatial patterns of elevated wall shear stress and pressure due to blood flow past aortic stenosis (AS) are studied using GPU-accelerated patient-specific computational fluid dynamics. Three cases of moderate AS, one with a dilated…

Fluid Dynamics · Physics 2022-12-13 Hadi Zolfaghari , Mervyn Andiapen , Andreas Baumbach , Anthony Mathur , Rich R. Kerswell

Abdominal aortic aneurysms (AAA) pose a significant clinical risk due to their potential for rupture, which is often asymptomatic but can be fatal. Although maximum diameter is commonly used for risk assessment, diameter alone is…

Image and Video Processing · Electrical Eng. & Systems 2025-08-28 Utsav Ratna Tuladhar , Richard Simon , Doran Mix , Michael Richards

The complexity of the cardiovascular system needs to be accurately reproduced in order to promptly acknowledge health conditions; to this aim, advanced multifidelity and multiphysics numerical models are crucial. On one side, Full Order…

Quantitative descriptors convert high-dimensional medical images into low-dimensional features capable of differentiating organ shapes that correlate with injury or disease progression for diagnostic purposes. An important example is aortic…

Tissues and Organs · Quantitative Biology 2025-11-19 Cooper Bruno , Tiago Cecchi , Joseph A. Pugar , Luka Pocivavsek , Newell Washburn

BACKGROUND: Proptosis is characterized by a protrusion of the eyeball due to an increase of the orbital tissue volume. To recover a normal eyeball positioning, the most frequent surgical technique consists in the osteotomy of orbital walls…

Medical Physics · Physics 2007-05-23 Vincent Luboz , Dominique Ambard , Pascal Swider , Franck Boutault , Yohan Payan

This study investigates the influence of aneurysm evolution on hemodynamic characteristics within the sac region. Using computational fluid dynamics (CFD), blood flow through the parent vessel and aneurysm sac was analyzed to assess the…

Quantitative Methods · Quantitative Biology 2026-02-17 Reza Bozorgpour , Jacob R. Rammer

In CT angiography, the accurate segmentation of abdominal aortic aneurysms (AAAs) is difficult due to large anatomical variability, low-contrast vessel boundaries, and the close proximity of organs whose intensities resemble vascular…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Osamah Sufyan , Martin Brückmann , Ralph Wickenhöfer , Babette Dellen , Uwe Jaekel

Purpose: To construct a neural network model that can learn the different diagnosing strategies of radiologists to better classify aneurysm status in magnetic resonance angiography images. Materials and methods: This retrospective study…

Image and Video Processing · Electrical Eng. & Systems 2020-02-06 Yasuhiko Tachibana , Masataka Nishimori , Naoyuki Kitamura , Kensuke Umehara , Junko Ota , Takayuki Obata , Tatsuya Higashi

An additive growth curve model with orthogonal design matrices is proposed in which observations may have different profile forms. The proposed model allows us to fit data and then estimate parameters in a more parsimonious way than the…

Statistics Theory · Mathematics 2012-01-06 Jianhua Hu , Guohua Yan , Jinhong You

From infancy to adulthood, human growth is anisotropic, much more along the proximal-distal axis (height) than along the medial-lateral axis (width), particularly at extremities. Detecting and modeling the rate of anisotropy in fingerprint…

Applications · Statistics 2018-01-22 Karla Markert , Karolin Krehl , Carsten Gottschlich , Stephan F. Huckemann

Intracranial aneurysms remain a major cause of neurological morbidity and mortality worldwide, where rupture risk is tightly coupled to local hemodynamics particularly wall shear stress and oscillatory shear index. Conventional…

Background:Subarachnoid hemorrhage caused by ruptured cerebral aneurysm often leads to fatal consequences.However,if the aneurysm can be found and treated during asymptomatic periods,the probability of rupture can be greatly reduced.At…

Image and Video Processing · Electrical Eng. & Systems 2021-10-27 Chen Geng , Meng Chen , Ruoyu Di , Dongdong Wang , Liqin Yang , Wei Xia , Yuxin Li , Daoying Geng

Purpose. It has been reported clinically that rupture or dissections in thoracic aortic aneurysms (TAA) often occur due to hypertension which may be modelled with sudden increase of peripheral resistance, inducing acute changes of blood…

Craniofacial anomalies indicate early developmental disturbances and are usually linked to many genetic syndromes. Early diagnosis is critical, yet ultrasound (US) examinations often fail to identify these features. This study presents an…

Image and Video Processing · Electrical Eng. & Systems 2024-09-05 Antonia Alomar , Ricardo Rubio , Laura Salort , Gerard Albaiges , Antoni Payà , Gemma Piella , Federico Sukno

Abdominal aortic aneurysms (AAAs) are progressive dilatations of the abdominal aorta that, if left untreated, can rupture with lethal consequences. Imaging-based patient monitoring is required to select patients eligible for surgical…

Image and Video Processing · Electrical Eng. & Systems 2023-03-03 Dieuwertje Alblas , Marieke Hofman , Christoph Brune , Kak Khee Yeung , Jelmer M. Wolterink

An abdominal aortic aneurysm (AAA) is an enlargement of the abdominal aorta which, if left untreated, can progressively widen and may rupture with fatal consequences. In this paper, we determine an optimal treatment policy using Markov…

Systems and Control · Computer Science 2016-11-08 Robert Mattila , Antti Siika , Joy Roy , Bo Wahlberg

Personalized, accurate prediction of aortic aneurysm progression is essential for timely intervention but remains challenging due to the need to model both subtle local deformations and global anatomical changes within complex 3D…

Rupture of intracranial aneurysms results in severe subarachnoidal hemorrhage, which is associated with high morbidity and mortality. Neurointerventional occlusion of the aneurysm through coiling has evolved to a therapeutical standard. The…

Computational Engineering, Finance, and Science · Computer Science 2024-03-12 Julian Schwarting , Fabian Holzberger , Markus Muhr , Martin Renz , Tobias Boeckh-Behrens , Barbara Wohlmuth , Jan Kirschke

In this paper, we present a computer-assisted method for facial reconstruction. This method provides an estimation of the facial shape associated with unidentified skeletal remains. Current computer-assisted methods using a statistical…

Machine Learning · Computer Science 2012-02-15 Maxime Berar , Françoise Tilotta , Joan Alexis Glaunès , Yves Rozenholc