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Shortcut learning, i.e., a model's reliance on undesired features not directly relevant to the task, is a major challenge that severely limits the applications of machine learning algorithms, particularly when deploying them to assist in…

Machine Learning · Computer Science 2025-06-17 Lukas Kuhn , Sari Sadiya , Jorg Schlotterer , Florian Buettner , Christin Seifert , Gemma Roig

This study investigates the critical problem of overfitting in deep learning models applied to histopathology image analysis. We show that simply adopting and fine-tuning large-scale models designed for natural image analysis often leads to…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 Saghir Alfasly , Ghazal Alabtah , H. R. Tizhoosh

The histopathological analysis of whole-slide images (WSIs) is fundamental to cancer diagnosis but is a time-consuming and expert-driven process. While deep learning methods show promising results, dominant patch-based methods artificially…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Alexander Weers , Alexander H. Berger , Laurin Lux , Peter Schüffler , Daniel Rueckert , Johannes C. Paetzold

Deep-learning models can extract a rich assortment of features from data. Which features a model uses depends not only on \emph{predictivity} -- how reliably a feature indicates training-set labels -- but also on \emph{availability} -- how…

Machine Learning · Computer Science 2024-07-15 Katherine L. Hermann , Hossein Mobahi , Thomas Fel , Michael C. Mozer

Few-shot learning is a standard practice in most deep learning based histopathology image segmentation, given the relatively low number of digitized slides that are generally available. While many models have been developed for domain…

Image and Video Processing · Electrical Eng. & Systems 2021-10-01 Zheng Yuan , Andre Esteva , Ran Xu

Medical imaging plays a vital role in modern diagnostics; however, interpreting high-resolution radiological data remains time-consuming and susceptible to variability among clinicians. Traditional image processing techniques often lack the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Melika Filvantorkaman , Maral Filvan Torkaman

Robust benchmarks are crucial for evaluating Multimodal Large Language Models (MLLMs). Yet we find that models can ace many multimodal benchmarks without strong visual understanding, instead exploiting biases, linguistic priors, and…

Computer Vision and Pattern Recognition · Computer Science 2025-11-07 Ellis Brown , Jihan Yang , Shusheng Yang , Rob Fergus , Saining Xie

Reliably detecting diseases using relevant biological information is crucial for real-world applicability of deep learning techniques in medical imaging. We debias deep learning models during training against unknown bias - without…

Computer Vision and Pattern Recognition · Computer Science 2022-06-09 Simon Langer , Oliver Taubmann , Felix Denzinger , Andreas Maier , Alexander Mühlberg

Deep neural networks do not discriminate between spurious and causal patterns, and will only learn the most predictive ones while ignoring the others. This shortcut learning behaviour is detrimental to a network's ability to generalize to…

Machine Learning · Computer Science 2023-01-11 Thomas Duboudin , Emmanuel Dellandréa , Corentin Abgrall , Gilles Hénaff , Liming Chen

A recent study has shown that large-scale visual datasets are very biased: they can be easily classified by modern neural networks. However, the concrete forms of bias among these datasets remain unclear. In this study, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2024-12-04 Boya Zeng , Yida Yin , Zhuang Liu

Driven by the recent advances in deep learning methods and, in particular, by the development of modern self-supervised learning algorithms, increased interest and efforts have been devoted to build foundation models (FMs) for medical…

Computer Vision and Pattern Recognition · Computer Science 2024-04-24 kaiko. ai , Nanne Aben , Edwin D. de Jong , Ioannis Gatopoulos , Nicolas Känzig , Mikhail Karasikov , Axel Lagré , Roman Moser , Joost van Doorn , Fei Tang

Deep learning has recently gained popularity in digital pathology due to its high prediction quality. However, the medical domain requires explanation and insight for a better understanding beyond standard quantitative performance…

Image and Video Processing · Electrical Eng. & Systems 2020-04-28 Miriam Hägele , Philipp Seegerer , Sebastian Lapuschkin , Michael Bockmayr , Wojciech Samek , Frederick Klauschen , Klaus-Robert Müller , Alexander Binder

The field of digital pathology has seen a proliferation of deep learning models in recent years. Despite substantial progress, it remains rare for other researchers and pathologists to be able to access models published in the literature…

Tissues and Organs · Quantitative Biology 2024-01-15 Jakub R. Kaczmarzyk , Alan O'Callaghan , Fiona Inglis , Tahsin Kurc , Rajarsi Gupta , Erich Bremer , Peter Bankhead , Joel H. Saltz

Foundation models, large-scale, pre-trained deep-learning models adapted to a wide range of downstream tasks have gained significant interest lately in various deep-learning problems undergoing a paradigm shift with the rise of these…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Bobby Azad , Reza Azad , Sania Eskandari , Afshin Bozorgpour , Amirhossein Kazerouni , Islem Rekik , Dorit Merhof

Deep neural networks are increasingly employed in high-stakes medical applications, despite their tendency for shortcut learning in the presence of spurious correlations, which can have potentially fatal consequences in practice. Whereas a…

Artificial Intelligence · Computer Science 2025-07-30 Frederik Pahde , Thomas Wiegand , Sebastian Lapuschkin , Wojciech Samek

Hyperspectral Imaging (HSI) serves as a non-destructive spatial spectroscopy technique with a multitude of potential applications. However, a recurring challenge lies in the limited size of the target datasets, impeding exhaustive…

Computer Vision and Pattern Recognition · Computer Science 2023-09-21 Hannah Frank , Leon Amadeus Varga , Andreas Zell

Machine learning is a data-driven field, and the quality of the underlying datasets plays a crucial role in learning success. However, high performance on held-out test data does not necessarily indicate that a model generalizes or learns…

Computer Vision and Pattern Recognition · Computer Science 2023-05-24 Nicolas M. Müller , Jochen Jacobs , Jennifer Williams , Konstantin Böttinger

Recent studies have noted an intriguing phenomenon termed Neural Collapse, that is, when the neural networks establish the right correlation between feature spaces and the training targets, their last-layer features, together with the…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Yining Wang , Junjie Sun , Chenyue Wang , Mi Zhang , Min Yang

Deep neural networks often struggle to learn robust representations in the presence of dataset biases, leading to suboptimal generalization on unbiased datasets. This limitation arises because the models heavily depend on peripheral and…

Machine Learning · Computer Science 2024-12-11 Carlo Alberto Barbano , Enzo Tartaglione , Marco Grangetto

Many machine learning algorithms are trained and evaluated by splitting data from a single source into training and test sets. While such focus on in-distribution learning scenarios has led to interesting advancement, it has not been able…

Computer Vision and Pattern Recognition · Computer Science 2020-07-02 Hyojin Bahng , Sanghyuk Chun , Sangdoo Yun , Jaegul Choo , Seong Joon Oh
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