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Deep convolutional neural networks (CNNs) are the current state-of-the-art for digital analysis of histopathological images. The large size of whole-slide microscopy images (WSIs) requires advanced memory handling to read, display and…

Machine Learning · Computer Science 2020-11-13 André Pedersen , Marit Valla , Anna M. Bofin , Javier Pérez de Frutos , Ingerid Reinertsen , Erik Smistad

It has recently been shown that deep learning models for anatomical segmentation in medical images can exhibit biases against certain sub-populations defined in terms of protected attributes like sex or ethnicity. In this context, auditing…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Nicolás Gaggion , Rodrigo Echeveste , Lucas Mansilla , Diego H. Milone , Enzo Ferrante

Deep Learning has already been successfully applied to analyze industrial sensor data in a variety of relevant use cases. However, the opaque nature of many well-performing methods poses a major obstacle for real-world deployment.…

Machine Learning · Computer Science 2023-10-20 Thomas Decker , Michael Lebacher , Volker Tresp

It is widely recognized that deep neural networks are sensitive to bias in the data. This means that during training these models are likely to learn spurious correlations between data and labels, resulting in limited generalization…

Machine Learning · Computer Science 2024-12-06 Vito Paolo Pastore , Massimiliano Ciranni , Davide Marinelli , Francesca Odone , Vittorio Murino

Although supervised deep-learning has achieved promising performance in medical image segmentation, many methods cannot generalize well on unseen data, limiting their real-world applicability. To address this problem, we propose a deep…

Image and Video Processing · Electrical Eng. & Systems 2022-06-10 Shangqi Gao , Hangqi Zhou , Yibo Gao , Xiahai Zhuang

Computational pathology tasks have some unique characterises such as multi-gigapixel images, tedious and frequently uncertain annotations, and unavailability of large number of cases [13]. To address some of these issues, we present Deep…

Image and Video Processing · Electrical Eng. & Systems 2023-01-24 Nima Hatami

Deep, overparameterized regression models are notorious for their tendency to overfit. This problem is exacerbated in heteroskedastic models, which predict both mean and residual noise for each data point. At one extreme, these models fit…

Machine Learning · Statistics 2024-02-15 Eliot Wong-Toi , Alex Boyd , Vincent Fortuin , Stephan Mandt

Deep learning is a topic of considerable current interest. The availability of massive data collections and powerful software resources has led to an impressive amount of results in many application areas that reveal essential but hidden…

Machine Learning · Computer Science 2023-01-31 Gianluigi Pillonetto , Aleksandr Aravkin , Daniel Gedon , Lennart Ljung , Antônio H. Ribeiro , Thomas B. Schön

Foundation models for computational pathology are expected to facilitate the development of high-performing, generalisable deep learning systems. However, in addition to biologically relevant features, current foundation models also capture…

Deep learning models often achieve high performance by inadvertently learning spurious correlations between targets and non-essential features. For example, an image classifier may identify an object via its background that spuriously…

Machine Learning · Computer Science 2025-06-19 Guangtao Zheng , Wenqian Ye , Aidong Zhang

Text-to-Image (T2I) models generate high-quality images but are vulnerable to malicious backdoor attacks that inject harmful biases (e.g., trigger-activated gender or racial stereotypes). Existing debiasing methods, often designed for…

Computer Vision and Pattern Recognition · Computer Science 2026-03-02 Hongyi Cai , Mohammad Mahdinur Rahman , Mingkang Dong , Muxin Pu , Moqyad Alqaily , Jie Li , Xinfeng Li , Jialie Shen , Meikang Qiu , Qingsong Wen

Histopathology images; microscopy images of stained tissue biopsies contain fundamental prognostic information that forms the foundation of pathological analysis and diagnostic medicine. However, diagnostics from histopathology images…

Computer Vision and Pattern Recognition · Computer Science 2019-10-30 Aïcha BenTaieb , Ghassan Hamarneh

Shortcut learning is a phenomenon where machine learning models prioritize learning simple, potentially misleading cues from data that do not generalize well beyond the training set. While existing research primarily investigates this in…

Image and Video Processing · Electrical Eng. & Systems 2024-06-28 Manxi Lin , Nina Weng , Kamil Mikolaj , Zahra Bashir , Morten Bo Søndergaard Svendsen , Martin Tolsgaard , Anders Nymark Christensen , Aasa Feragen

The rapid advancement of generative AI has enabled the mass production of photorealistic synthetic images, blurring the boundary between authentic and fabricated visual content. This challenge is particularly evident in deepfake scenarios…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Minsun Jeon , Simon S. Woo

As data grows in size and complexity, finding frameworks which aid in interpretation and analysis has become critical. This is particularly true when data comes from complex systems where extensive structure is available, but must be drawn…

Machine Learning · Computer Science 2021-05-24 Henry Kvinge , Brett Jefferson , Cliff Joslyn , Emilie Purvine

To handle the large scale of whole slide images in computational pathology, most approaches first tessellate the images into smaller patches, extract features from these patches, and finally aggregate the feature vectors with…

Computer Vision and Pattern Recognition · Computer Science 2025-03-05 Benedikt Roth , Valentin Koch , Sophia J. Wagner , Julia A. Schnabel , Carsten Marr , Tingying Peng

Deep image prior (DIP) is an unsupervised deep learning framework that has been successfully applied to a variety of inverse imaging problems. However, DIP-based methods are inherently prone to overfitting, which leads to performance…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Panagiotis Gkotsis , Athanasios A. Rontogiannis

NLU models often exploit biases to achieve high dataset-specific performance without properly learning the intended task. Recently proposed debiasing methods are shown to be effective in mitigating this tendency. However, these methods rely…

Computation and Language · Computer Science 2020-10-14 Prasetya Ajie Utama , Nafise Sadat Moosavi , Iryna Gurevych

Recent years witnessed remarkable progress in computational histopathology, largely fueled by deep learning. This brought the clinical adoption of deep learning-based tools within reach, promising significant benefits to healthcare,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-29 Ahmad Obeid , Said Boumaraf , Anabia Sohail , Taimur Hassan , Sajid Javed , Jorge Dias , Mohammed Bennamoun , Naoufel Werghi

Medical multimodal representation learning aims to integrate heterogeneous data into unified patient representations to support clinical outcome prediction. However, real-world medical datasets commonly contain systematic biases from…

Machine Learning · Computer Science 2026-05-19 Xiaoguang Zhu , Linxiao Gong , Lianlong Sun , Yang Liu , Haoyu Wang , Jing Liu