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Objective: Deformable brain MR image registration is challenging due to large inter-subject anatomical variation. For example, the highly complex cortical folding pattern makes it hard to accurately align corresponding cortical structures…

Computer Vision and Pattern Recognition · Computer Science 2019-02-07 Dongming Wei , Zhengwang Wu , Gang Li , Xiaohuan Cao , Dinggang Shen , Qian Wang

Standard registration algorithms need to be independently applied to each surface to register, following careful pre-processing and hand-tuning. Recently, learning-based approaches have emerged that reduce the registration of new scans to…

Computer Vision and Pattern Recognition · Computer Science 2021-03-11 Mehdi Bahri , Eimear O' Sullivan , Shunwang Gong , Feng Liu , Xiaoming Liu , Michael M. Bronstein , Stefanos Zafeiriou

Nonlinear registration of 2D histological sections with corresponding slices of MRI data is a critical step of 3D histology reconstruction. This task is difficult due to the large differences in image contrast and resolution, as well as the…

Computer Vision and Pattern Recognition · Computer Science 2018-09-28 Juan Eugenio Iglesias , Marc Modat , Loic Peter , Allison Stevens , Roberto Annunziata , Tom Vercauteren , Ed Lein , Bruce Fischl , Sebastien Ourselin

Medical image registration is a critical process that aligns various patient scans, facilitating tasks like diagnosis, surgical planning, and tracking. Traditional optimization based methods are slow, prompting the use of Deep Learning (DL)…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Amin Ranem , John Kalkhof , Anirban Mukhopadhyay

In this work, we introduce a fast and accurate method for unsupervised 3D medical image registration. This work is built on top of a recent algorithm SAM, which is capable of computing dense anatomical/semantic correspondences between two…

Image and Video Processing · Electrical Eng. & Systems 2021-09-27 Fengze Liu , Ke Yan , Adam Harrison , Dazhou Guo , Le Lu , Alan Yuille , Lingyun Huang , Guotong Xie , Jing Xiao , Xianghua Ye , Dakai Jin

The majority of current research in deep learning based image registration addresses inter-patient brain registration with moderate deformation magnitudes. The recent Learn2Reg medical registration benchmark has demonstrated that…

Computer Vision and Pattern Recognition · Computer Science 2022-03-02 Mattias P. Heinrich , Lasse Hansen

We introduce SparseVM, a method that registers clinical-quality 3D MR scans both faster and more accurately than previously possible. Deformable alignment, or registration, of clinical scans is a fundamental task for many clinical…

Computer Vision and Pattern Recognition · Computer Science 2020-04-07 Kathleen M. Lewis , Natalia S. Rost , John Guttag , Adrian V. Dalca

Retrospective analysis of brain MRI scans acquired in the clinic has the potential to enable neuroimaging studies with sample sizes much larger than those found in research datasets. However, analysing such clinical images "in the wild" is…

Image and Video Processing · Electrical Eng. & Systems 2023-01-06 Benjamin Billot , Magdamo Colin , Sean E. Arnold , Sudeshna Das , Juan. E. Iglesias

We introduce a strategy for learning image registration without acquired imaging data, producing powerful networks agnostic to contrast introduced by magnetic resonance imaging (MRI). While classical registration methods accurately estimate…

Image and Video Processing · Electrical Eng. & Systems 2022-03-04 Malte Hoffmann , Benjamin Billot , Douglas N. Greve , Juan Eugenio Iglesias , Bruce Fischl , Adrian V. Dalca

We present VoxelMorph, a fast learning-based framework for deformable, pairwise medical image registration. Traditional registration methods optimize an objective function for each pair of images, which can be time-consuming for large…

Computer Vision and Pattern Recognition · Computer Science 2019-09-04 Guha Balakrishnan , Amy Zhao , Mert R. Sabuncu , John Guttag , Adrian V. Dalca

A significant challenge for brain histological data analysis is to precisely identify anatomical regions in order to perform accurate local quantifications and evaluate therapeutic solutions. Usually, this task is performed manually,…

Image and Video Processing · Electrical Eng. & Systems 2021-12-08 Sébastien Piluso , Nicolas Souedet , Caroline Jan , Cédric Clouchoux , Thierry Delzescaux

Every year, millions of brain MRI scans are acquired in hospitals, which is a figure considerably larger than the size of any research dataset. Therefore, the ability to analyse such scans could transform neuroimaging research. Yet, their…

Image and Video Processing · Electrical Eng. & Systems 2023-03-29 Benjamin Billot , Colin Magdamo , You Cheng , Steven E. Arnold , Sudeshna Das , Juan. E. Iglesias

The purpose of this study is to develop a deep learning based method that can automatically generate segmentations on cone-beam CT (CBCT) for head and neck online adaptive radiation therapy (ART), where expert-drawn contours in planning CT…

Medical Physics · Physics 2021-02-02 Xiao Liang , Howard Morgan , Dan Nguyen , Steve Jiang

The thickness of the cortical band is linked to various neurological and psychiatric conditions, and is often estimated through surface-based methods such as Freesurfer in MRI studies. The DiReCT method, which calculates cortical thickness…

Image and Video Processing · Electrical Eng. & Systems 2023-07-24 Richard McKinley , Christian Rummel

Skull-stripping is the removal of background and non-brain anatomical features from brain images. While many skull-stripping tools exist, few target pediatric populations. With the emergence of multi-institutional pediatric data acquisition…

Image and Video Processing · Electrical Eng. & Systems 2025-12-05 William Kelley , Nathan Ngo , Adrian V. Dalca , Bruce Fischl , Lilla Zöllei , Malte Hoffmann

Melanoma brain metastases (MBM) are common and spatially heterogeneous lesions, complicating cohort-level analyses due to anatomical variability and differing MRI protocols. We propose a fully differentiable, deep-learning-based deformable…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Nanna E. Wielenberg , Ilinca Popp , Oliver Blanck , Lucas Zander , Jan C. Peeken , Stephanie E. Combs , Anca-Ligia Grosu , Dimos Baltas , Tobias Fechter

The recent application of deep learning in various areas of medical image analysis has brought excellent performance gains. In particular, technologies based on deep learning in medical image registration can outperform traditional…

Image and Video Processing · Electrical Eng. & Systems 2019-09-09 Abdullah Nazib , Clinton Fookes , Dimitri Perrin

Precise segmentation of brain structures in magnetic resonance imaging (MRI) is essential for reliable neuroimaging analysis, yet voxel-wise deep models often yield anatomically inconsistent results that diverge from expert-defined…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Ahmed Rekik , R. Jarrett Rushmore , Sylvain Bouix , Linda Marrakchi-Kacem

A lot of image registration techniques have been developed with great significance for data analysis in medicine, astrophotography, satellite imaging and few other areas. This work proposes a method for medical image registration using Fast…

Computer Vision and Pattern Recognition · Computer Science 2015-05-19 D. Sasikala , R. Neelaveni

Human anatomy, morphology, and associated diseases can be studied using medical imaging data. However, access to medical imaging data is restricted by governance and privacy concerns, data ownership, and the cost of acquisition, thus…