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Hybrid models of chemotaxis combine agent-based models of cells with partial differential equation models of extracellular chemical signals. In this paper, travelling wave properties of hybrid models of bacterial chemotaxis are…

Biological Physics · Physics 2013-02-13 Benjamin Franz , Chuan Xue , Kevin J. Painter , Radek Erban

We study the effect of advection on the aggregation and pattern formation in chemotactic systems described by Keller-Segel type models. The evolution of small perturbations is studied analytically in the linear regime complemented by…

Statistical Mechanics · Physics 2015-05-13 Javier Muñoz-García , Zoltán Neufeld

We introduce mesoscopic and macroscopic model equations of chemotaxis with anomalous subdiffusion for modelling chemically directed transport of biological organisms in changing chemical environments with diffusion hindered by traps or…

Dynamical Systems · Mathematics 2012-12-03 T. A. M. Langlands , B. I. Henry

Living cells are capable of interacting with their environments in a variety of ways, including cell signalling, adhesion, and directed motion. These behaviours are often mediated by receptor molecules embedded in the cell membrane, which…

Biological Physics · Physics 2023-10-17 Hannah Sleath , Bortolo Mognetti , Yuval Elani , Lorenzo Di Michele

Self-generated gradients (SGG) provide robust steering cues that guide cells in their long-distance expeditions during embryonic development, immune response, and cancer metastasis. Cells generate their own local, dynamic gradients by…

Soft Condensed Matter · Physics 2021-09-29 Himadri S Samanta

Chemotaxis in bacteria such as \textit{E.\ coli} is controlled by the slow methylation of chemoreceptors. As a consequence, intrinsic time and length scales of tens of seconds and hundreds of micrometers emerge, making the Keller--Segel…

Soft Condensed Matter · Physics 2025-04-23 Manuel Mayo , Rodrigo Soto

The collective chemotaxis of multicellular clusters is an important phenomenon in various physiological contexts, ranging from embryonic development to cancer metastasis. Such clusters often display interesting shape dynamics and…

Tissues and Organs · Quantitative Biology 2025-06-03 Monika Sanoria , Gema Malet-Engra , Giorgio Scita , Nir Gov , Ajay Gopinathan

The Keller-Segel model is a well-known system representing chemotaxis in living organisms. We study the convergence of a generalized nonlinear variant of the Keller-Segel to the degenerate Cahn-Hilliard system. This analysis is made…

Analysis of PDEs · Mathematics 2023-02-13 Charles Elbar , Benoît Perthame , Alexandre Poulain

Single-cell organisms and various cell types use a range of motility modes when following a chemical gradient, but it is unclear which mode is best suited for different gradients. Here, we model directional decision-making in chemotactic…

Cell Behavior · Quantitative Biology 2025-05-12 Albert Alonso , Julius B. Kirkegaard , Robert G. Endres

We provide a review of recent advancements in nonlocal continuous models for migration, mainly from the perspective of its involvement in embryonal development and cancer invasion. Particular emphasis is placed on spatial nonlocality…

Analysis of PDEs · Mathematics 2019-11-14 Li Chen , Kevin Painter , Christina Surulescu , Anna Zhigun

We study an anomalous behavior observed in interacting E. coli populations. When two populations of E. coli are placed on opposite ends of a long channel with a supply of nutrient between them, they will travel as pulses toward one another…

Cell Behavior · Quantitative Biology 2017-04-25 Glenn Young , Mahmut Demir , Hanna Salman , G. Bard Ermentrout , Jonathan E. Rubin

Motile bacteria can migrate along chemical gradients in a process known as chemotaxis. When exposed to uniform environmental stress, Escherichia coli cells coordinate their chemotactic responses to form millimeter-sized condensates…

Biological Physics · Physics 2025-05-02 Nir Livne , Ady Vaknin , Oded Agam

Chemotaxis, the directional locomotion of cells towards a source of a chemical gradient, is an integral part of many biological processes - for example, bacteria motion, single-cell or multicellular organisms development, immune response,…

Analysis of PDEs · Mathematics 2021-03-29 Yishu Gong , Alexander Kiselev

Directed fibroblast migration is central to highly proliferative processes in regenerative medicine and developmental biology, such as wound healing and embryogenesis. However, the mechanisms by which single fibroblasts affect each other's…

Cell Behavior · Quantitative Biology 2018-08-29 Q. L. Pham , D. Chege , T. Dijamco , J. Brito , E. Stein , N. A. N. Tong , S. Basuray , R. S. Voronov

A common feature of biological self-organization is how active agents communicate with each other or their environment via chemical signaling. Such communications, mediated by self-generated chemical gradients, have consequences for both…

Soft Condensed Matter · Physics 2023-11-07 Babak Vajdi Hokmabad , Suropriya Saha , Jaime Agudo-Canalejo , Ramin Golestanian , Corinna C. Maass

Simulations are performed to investigate the nonlinear dynamics of a (2+1)-dimensional chemotaxis model of Keller-Segel (KS) type with a logistic growth term. Because of its ability to display auto-aggregation, the KS model has been widely…

Biological Physics · Physics 2011-11-14 S. Banerjee , A. P. Misra , L. Rondoni

Collective migration -- the directed, coordinated motion of many self-propelled agents -- is a fascinating emergent behavior exhibited by active matter that has key functional implications for biological systems. Extensive studies have…

Biological Physics · Physics 2022-06-07 Tapomoy Bhattacharjee , Daniel B. Amchin , Ricard Alert , J. A. Ott , Sujit S. Datta

We consider a generalized class of Keller-Segel models describing the chemotaxis of biological populations (bacteria, amoebae, endothelial cells, social insects,...). We show the analogy with nonlinear mean field Fokker-Planck equations and…

Biological Physics · Physics 2016-11-23 Pierre-Henri Chavanis

Cell sorting, whereby a heterogeneous cell mixture segregates and forms distinct homogeneous tissues, is one of the main collective cell behaviors at work during development. Although differences in interfacial energies are recognized to be…

Soft Condensed Matter · Physics 2022-07-15 Marc Durand

We develop and analyse a discrete, one-dimensional model of cell motility which incorporates the effects of volume filling, cell-to-cell adhesion and chemotaxis. The formal continuum limit of the model is a nonlinear generalisation of the…

Analysis of PDEs · Mathematics 2011-01-14 K. Anguige
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