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Traditional causal connectivity methods in task-based and resting-state functional magnetic resonance imaging (fMRI) face challenges in accurately capturing directed information flow due to their sensitivity to noise and inability to model…

Neurons and Cognition · Quantitative Biology 2025-04-03 Boseong Kim , Debashis Das Chakladar , Haejun Chung , Ikbeom Jang

Statistical techniques are needed to analyse data structures with complex dependencies such that clinically useful information can be extracted. Individual-specific networks, which capture dependencies in complex biological systems, are…

Methodology · Statistics 2023-08-30 Mariella Gregorich , Sean L. Simpson , Georg Heinze

Alterations in functional brain connectivity characterize neurodegenerative disorders such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). As a non-invasive and cost-effective technique, electroencephalography (EEG) is…

Applications · Statistics 2025-11-19 Paolo Victor Redondo , Raphaël Huser , Hernando Ombao

The primary goal of this paper is to develop a method that quantifies how activity in one brain region can explain future activity in another region. Here, we propose the mixed effects spectral vector-autoregressive (ME-SpecVar) model to…

Applications · Statistics 2022-10-07 Anastasiia Malinovskaia

Motivated by the need for computationally tractable spatial methods in neuroimaging studies, we develop a distributed and integrated framework for estimation and inference of Gaussian process model parameters with ultra-high-dimensional…

Methodology · Statistics 2024-02-09 Emily C. Hector , Brian J. Reich , Ani Eloyan

An increasingly important goal of psychiatry is the use of brain imaging data to develop predictive models. Here we present two contributions to statistical methodology for this purpose. First, we propose and compare a set of wavelet-domain…

Applications · Statistics 2015-09-17 Philip T. Reiss , Lan Huo , Yihong Zhao , Clare Kelly , R. Todd Ogden

Theories for autism spectrum disorder (ASD) have been formulated at different levels: ranging from physiological observations to perceptual and behavioral descriptions. Understanding the physiological underpinnings of perceptual traits in…

Neurons and Cognition · Quantitative Biology 2021-12-03 Rodrigo Echeveste , Enzo Ferrante , Diego H. Milone , Inés Samengo

Understanding the complex neural activity dynamics is crucial for the development of the field of neuroscience. Although current functional MRI classification approaches tend to be based on static functional connectivity or cannot capture…

Machine Learning · Computer Science 2025-08-20 Amirali Arbab , Zeinab Davarani , Mehran Safayani

While the prevalence of Autism Spectrum Disorder (ASD) is increasing, research continues in an effort to identify common etiological and pathophysiological bases. In this regard, modern machine learning and network science pave the way for…

Image and Video Processing · Electrical Eng. & Systems 2020-08-06 Sarah Itani , Dorina Thanou

A developmental disorder that severely damages communicative and social functions, the Autism Spectrum Disorder (ASD) also presents aspects related to mental rigidity, repetitive behavior, and difficulty in abstract reasoning. More,…

Neural and Evolutionary Computing · Computer Science 2018-11-20 Daniele Q. M. Madureira , Vera Lucia P. S. Caminha , Rogerio Salvini

Finding the underlying relationships among multiple imaging modalities in a coherent fashion is one of challenging problems in the multimodal analysis. In this study, we propose a novel multimodal network approach based on multidi-…

Quantitative Methods · Quantitative Biology 2016-02-26 Hyekyoung Lee , Hyejin Kang , Moo K. Chung , Seonhee Lim , Bung-Nyun Kim , Dong Soo Lee

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder impacting social and behavioral development. Resting-state fMRI, a non-invasive tool for capturing brain connectivity patterns, aids in early ASD diagnosis and differentiation…

Machine Learning · Computer Science 2025-02-27 Ziqiao Weng , Weidong Cai , Bo Zhou

In neuroimaging, a large number of correlated tests are routinely performed to detect active voxels in single-subject experiments or to detect regions that differ between individuals belonging to different groups. In order to bound the…

We present a statistical framework that jointly models brain shape and functional connectivity, which are two complex aspects of the brain that have been classically studied independently. We adopt a Riemannian modeling approach to account…

Methodology · Statistics 2024-04-26 Eardi Lila , John A. D. Aston

The multifactorial etiology of autism spectrum disorder (ASD) suggests that its study would benefit greatly from multimodal approaches that combine data from widely varying platforms, e.g., neuroimaging, genetics, and clinical…

Quantitative Methods · Quantitative Biology 2023-08-11 Nicha C. Dvornek , Catherine Sullivan , James S. Duncan , Abha R. Gupta

Objective. The paper investigates the presence of autism using the functional brain connectivity measures derived from electro-encephalogram (EEG) of children during face perception tasks. Approach. Phase synchronized patterns from…

We propose a Bayesian framework for uncertainty quantification and comparison in brain connectivity graph analysis. Standard graph-based approaches typically rely on point estimates of correlation matrices, overlooking the uncertainty…

Methodology · Statistics 2026-05-29 Alice Chevaux , Julyan Arbel , Guillaume Kon Kam King , Sophie Achard

Effective connectivity analysis provides an understanding of the functional organization of the brain by studying how activated regions influence one other. We propose a nonparametric Bayesian approach to model effective connectivity…

Applications · Statistics 2011-07-22 Sourabh Bhattacharya , Ranjan Maitra

Currently, the diagnosis of Autism Spectrum Disorder (ASD) is dependent upon a subjective, time-consuming evaluation of behavioral tests by an expert clinician. Non-invasive functional MRI (fMRI) characterizes brain connectivity and may be…

Machine Learning · Computer Science 2020-05-26 Cooper J. Mellema , Alex Treacher , Kevin P. Nguyen , Albert Montillo

Brain connectome analysis commonly compresses high-resolution brain scans (typically composed of millions of voxels) down to only hundreds of regions of interest (ROIs) by averaging within-ROI signals. This huge dimension reduction improves…

Methodology · Statistics 2025-03-25 Tong Lu , Yuan Zhang , Peter Kochunov , Elliot Hong , Shuo Chen