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Analyzing whole-slide images (WSIs) requires an iterative, evidence-driven reasoning process that parallels how pathologists dynamically zoom, refocus, and self-correct while collecting the evidence. However, existing computational…

Computer Vision and Pattern Recognition · Computer Science 2025-11-24 Jingyun Chen , Linghan Cai , Zhikang Wang , Yi Huang , Songhan Jiang , Shenjin Huang , Hongpeng Wang , Yongbing Zhang

There is an increasing demand for computing the relevant structures, equilibria and long-timescale kinetics of biomolecular processes, such as protein-drug binding, from high-throughput molecular dynamics simulations. Current methods employ…

Machine Learning · Statistics 2018-02-07 Andreas Mardt , Luca Pasquali , Hao Wu , Frank Noé

Spatial transcriptomics reveals gene expression patterns within tissue context, enabling precision oncology applications such as treatment response prediction, but its high cost and technical complexity limit clinical adoption. Predicting…

Computer Vision and Pattern Recognition · Computer Science 2025-08-04 Won June Cho , Hongjun Yoon , Daeky Jeong , Hyeongyeol Lim , Yosep Chong

Despite deep convolutional neural networks boost the performance of image classification and segmentation in digital pathology analysis, they are usually weak in interpretability for clinical applications or require heavy annotations to…

Computer Vision and Pattern Recognition · Computer Science 2020-02-10 Yongxiang Huang , Albert C. S. Chung

Pathology has played a crucial role in the diagnosis and evaluation of patient tissue samples obtained from surgeries and biopsies for many years. The advent of Whole Slide Scanners and the development of deep learning technologies have…

Computer Vision and Pattern Recognition · Computer Science 2024-08-07 Mieko Ochi , Daisuke Komura , Shumpei Ishikawa

Image segmentation is crucial in many computational pathology pipelines, including accurate disease diagnosis, subtyping, outcome, and survivability prediction. The common approach for training a segmentation model relies on a pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Sachin Kumar Danisetty , Alexandros Graikos , Srikar Yellapragada , Dimitris Samaras

Clinical practice guidelines (CPGs) provide evidence-based recommendations for patient care; however, integrating them into Artificial Intelligence (AI) remains challenging. Previous approaches, such as rule-based systems, face significant…

Artificial Intelligence · Computer Science 2026-01-08 Ruiqi Deng , Geoffrey Martin , Tony Wang , Gongbo Zhang , Yi Liu , Chunhua Weng , Yanshan Wang , Justin F Rousseau , Yifan Peng

Intelligent analysis of medical imaging plays a crucial role in assisting clinical diagnosis, especially for identifying subtle pathological features. This paper introduces a novel multi-branch ConvNeXt architecture designed specifically…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Irash Perera , Uthayasanker Thayasivam

Estimating slide- and patch-level gene expression profiles from pathology images enables rapid and low-cost molecular analysis with broad clinical impact. Despite strong results, existing approaches treat gene expression as a mere slide- or…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Kazuya Nishimura , Ryoma Bise , Shinnosuke Matsuo , Haruka Hirose , Yasuhiro Kojima

Ultrasound imaging is widely used in clinical practice due to its cost-effectiveness, mobility, and safety. However, current AI research often treats disease prediction and tissue segmentation as two separate tasks and their model requires…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Zhi Chen , Le Zhang

Accurate classification of pediatric central nervous system tumors remains challenging due to histological complexity and limited training data. While pathology foundation models have advanced whole-slide image (WSI) analysis, they often…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Jian Yu , Joakim Nguyen , Jinrui Fang , Awais Naeem , Zeyuan Cao , Sanjay Krishnan , Nicholas Konz , Tianlong Chen , Chandra Krishnan , Hairong Wang , Edward Castillo , Ying Ding , Ankita Shukla

General-purpose Large Vision-Language Models (LVLMs), despite their massive scale, often falter in dermatology due to "diffuse attention" - the inability to disentangle subtle pathological lesions from background noise. In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Lijun Liu , Linwei Chen , Zhishou Zhang , Meng Tian , Hengfu Cui , Ruiyang Li , Zhaocheng Liu , Qiang Ju , Qianxi Li , Hong-Yu Zhou

Visual grounding focuses on detecting objects from images based on language expressions. Recent Large Vision-Language Models (LVLMs) have significantly advanced visual grounding performance by training large models with large-scale…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Yangxiao Lu , Ruosen Li , Liqiang Jing , Jikai Wang , Xinya Du , Yunhui Guo , Nicholas Ruozzi , Yu Xiang

Cancer survival prediction from multi-omics data remains challenging because prognostic signals are high-dimensional, heterogeneous, and distributed across interacting genes and pathways. We propose PathMoG, a pathway-centric modular graph…

Machine Learning · Computer Science 2026-04-28 Di Wang , Chupei Tang , Junxiao Kong , Jixiu Zhai , Moyu Tang , Tianchi Lu

Pathological image segmentation faces numerous challenges, particularly due to ambiguous semantic boundaries and the high cost of pixel-level annotations. Although recent semi-supervised methods based on consistency regularization (e.g.,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Mingxi Fu , Fanglei Fu , Xitong Ling , Huaitian Yuan , Tian Guan , Yonghong He , Lianghui Zhu

The design of widespread vision-and-language datasets and pre-trained encoders directly adopts, or draws inspiration from, the concepts and images of ImageNet. While one can hardly overestimate how much this benchmark contributed to…

Computation and Language · Computer Science 2021-10-25 Fangyu Liu , Emanuele Bugliarello , Edoardo Maria Ponti , Siva Reddy , Nigel Collier , Desmond Elliott

Traditionally, AI research in medical diagnosis has largely centered on image analysis. While this has led to notable advancements, the absence of patient-reported symptoms continues to hinder diagnostic accuracy. To address this, we…

Computer Vision and Pattern Recognition · Computer Science 2026-01-19 K Lokesh , Abhirama Subramanyam Penamakuri , Uday Agarwal , Apoorva Challa , Shreya K Gowda , Somesh Gupta , Anand Mishra

The rapidly evolving field of digital oncopathology faces significant challenges, including the need to address diverse and complex clinical questions, often involving rare conditions, with limited availability of labeled data. These…

Image and Video Processing · Electrical Eng. & Systems 2024-09-05 Jonathan Zalach , Inbal Gazy , Assaf Avinoam , Ron Sinai , Eran Shmuel , Inbar Gilboa , Christine Swisher , Naim Matasci , Reva Basho , David B. Agus

Purpose: Accurate identification of hepatocystic anatomy is critical to preventing surgical complications during laparoscopic cholecystectomy. Deep learning models often struggle with occlusions, long-range dependencies, and capturing the…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Yihan Li , Nikhil Churamani , Maria Robu , Imanol Luengo , Danail Stoyanov

Accurate segmentation of lesions plays a critical role in medical image analysis and diagnosis. Traditional segmentation approaches that rely solely on visual features often struggle with the inherent uncertainty in lesion distribution and…

Image and Video Processing · Electrical Eng. & Systems 2025-04-03 Dandan Shan , Zihan Li , Yunxiang Li , Qingde Li , Jie Tian , Qingqi Hong
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