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Anxiety and depression are the most common mental health issues worldwide, affecting a non-negligible part of the population. Accordingly, stakeholders, including governments' health systems, are developing new strategies to promote early…

Artificial Intelligence · Computer Science 2024-12-24 Francisco de Arriba-Pérez , Silvia García-Méndez

Clinical decision-making is inherently complex, often influenced by cognitive biases, incomplete information, and case ambiguity. Large Language Models (LLMs) have shown promise as tools for supporting clinical decision-making, yet their…

Machine Learning · Computer Science 2025-07-10 Burcu Sayin , Ipek Baris Schlicht , Ngoc Vo Hong , Sara Allievi , Jacopo Staiano , Pasquale Minervini , Andrea Passerini

Large Language Models (LLMs) have shown remarkable capabilities for complex tasks, yet adaptation in medical domain, specifically mental health, poses specific challenges. Mental health is a rising concern globally with LLMs having large…

Large Language Models (LLMs) have increasingly demonstrated the ability to facilitate the development of multi-agent systems that allow the interpretation of thoughts and actions generated by each individual. Promising advancements have…

Multiagent Systems · Computer Science 2024-09-24 Asher Sprigler , Alexander Drobek , Keagan Weinstock , Wendpanga Tapsoba , Gavin Childress , Andy Dao , Lucas Gral

Recent progress on large language models (LLMs) has enabled dialogue agents to generate highly naturalistic and plausible text. However, current LLM language generation focuses on responding accurately to questions and requests with a…

Machine Learning · Computer Science 2024-11-11 Joey Hong , Jessica Lin , Anca Dragan , Sergey Levine

The 2022 World Mental Health Report calls for global mental health care reform, amid rising prevalence of issues like anxiety and depression that affect nearly one billion people worldwide. Traditional in-person therapy fails to meet this…

Computers and Society · Computer Science 2025-10-21 Xun Wei , Pukai Zhou , Zeyu Wang

Large language models (LLMs) hold significant potential for mental health support, capable of generating empathetic responses and simulating therapeutic conversations. However, existing LLM-based approaches often lack the clinical grounding…

Computation and Language · Computer Science 2025-11-04 He Hu , Yucheng Zhou , Juzheng Si , Qianning Wang , Hengheng Zhang , Fuji Ren , Fei Ma , Laizhong Cui , Qi Tian

LLM-based agents have emerged as transformative tools capable of executing complex tasks through iterative planning and action, achieving significant advancements in understanding and addressing user needs. Yet, their effectiveness remains…

Human-Computer Interaction · Computer Science 2025-08-26 Mithat Can Ozgun , Jiahuan Pei , Koen Hindriks , Lucia Donatelli , Qingzhi Liu , Junxiao Wang

The integration of Large Language Models (LLMs) into the healthcare domain has the potential to significantly enhance patient care and support through the development of empathetic, patient-facing chatbots. This study investigates an…

Computation and Language · Computer Science 2024-05-28 Man Luo , Christopher J. Warren , Lu Cheng , Haidar M. Abdul-Muhsin , Imon Banerjee

The past decade has been transformative for mental health research and practice. The ability to harness large repositories of data, whether from electronic health records (EHR), mobile devices, or social media, has revealed a potential for…

Computation and Language · Computer Science 2023-11-28 Munmun De Choudhury , Sachin R. Pendse , Neha Kumar

Conversational agents have made significant progress since ELIZA, expanding their role across various domains, including healthcare, education, and customer service. As these agents become increasingly integrated into daily human…

Human-Computer Interaction · Computer Science 2025-07-04 Paulo Ricardo Knob , Leonardo Scholler , Juliano Rigatti , Soraia Raupp Musse

Large Language Models (LLMs) are transforming mental health care by enhancing accessibility, personalization, and efficiency in therapeutic interventions. These AI-driven tools empower mental health professionals with real-time support,…

Computers and Society · Computer Science 2025-01-22 Hari Mohan Pandey

Limited access to mental healthcare, extended wait times, and increasing capabilities of Large Language Models (LLMs) has led individuals to turn to LLMs for fulfilling their mental health needs. However, examining the multi-turn mental…

Computation and Language · Computer Science 2025-05-29 Mohit Chandra , Siddharth Sriraman , Harneet Singh Khanuja , Yiqiao Jin , Munmun De Choudhury

The era of Large Language Models (LLMs) presents a new opportunity for interpretability--agentic interpretability: a multi-turn conversation with an LLM wherein the LLM proactively assists human understanding by developing and leveraging a…

Artificial Intelligence · Computer Science 2025-06-17 Been Kim , John Hewitt , Neel Nanda , Noah Fiedel , Oyvind Tafjord

Simulations, although powerful in accurately replicating real-world systems, often remain inaccessible to non-technical users due to their complexity. Conversely, large language models (LLMs) provide intuitive, language-based interactions…

Computation and Language · Computer Science 2025-05-22 Jacob Kleiman , Kevin Frank , Joseph Voyles , Sindy Campagna

The advent of large language models (LLMs) has enabled agents to represent virtual humans in societal simulations, facilitating diverse interactions within complex social systems. However, existing LLM-based agents exhibit severe…

Artificial Intelligence · Computer Science 2025-10-16 Qun Ma , Xiao Xue , Xuwen Zhang , Zihan Zhao , Yuwei Guo , Ming Zhang

The ability of large language models (LLMs) to engage in credible dialogues with humans, taking into account the training data and the context of the conversation, has raised discussions about their ability to exhibit intrinsic motivations,…

Artificial Intelligence · Computer Science 2023-11-16 Arlindo L. Oliveira , Tiago Domingos , Mário Figueiredo , Pedro U. Lima

In healthcare intelligence, the ability to fuse heterogeneous, multi-intent information from diverse clinical sources is fundamental to building reliable decision-making systems. Large Language Model (LLM)-driven information interaction…

Computation and Language · Computer Science 2025-07-04 Dingkang Yang , Jinjie Wei , Mingcheng Li , Jiyao Liu , Lihao Liu , Ming Hu , Junjun He , Yakun Ju , Wei Zhou , Yang Liu , Lihua Zhang

Mental disorders represent a critical global health challenge, and social media is increasingly viewed as a vital resource for real-time digital phenotyping and intervention. To leverage this data, large language models (LLMs) have been…

Computation and Language · Computer Science 2025-12-23 Zhuohan Ge , Darian Li , Yubo Wang , Nicole Hu , Xinyi Zhu , Haoyang Li , Xin Zhang , Mingtao Zhang , Shihao Qi , Yuming Xu , Han Shi , Chen Jason Zhang , Qing Li

We introduce a general-purpose, human-in-the-loop dual dialogue system to support mental health care professionals. The system, co-designed with care providers, is conceptualized to assist them in interacting with care seekers rather than…