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Rare disease diagnosis is inherently challenging due to heterogeneous symptoms, limited clinical familiarity, and fragmented evidence across specialties. Recent large language model (LLM)-based agentic systems have shown promise by…

Human-Computer Interaction · Computer Science 2026-03-31 Peng Kuai , Yukun Yang , Shaolun Ruan , Junchi Xu , Yanjie Zhang , Lin Zhang , Min Zhu , Rui Sheng

Clinical Decision Support Systems (CDSSs) provide reasoning and inquiry guidance for physicians, yet they face notable challenges, including high maintenance costs and low generalization capability. Recently, Large Language Models (LLMs)…

Computation and Language · Computer Science 2026-04-24 Yue Guo , Fanfu Wang , Jianwei Lv , Xincheng Shi , Yuchen Li , Youya Wang , Yunsheng Zeng , Yujing Liu , Yunhao Qiao , Gen Li , Junfeng Wang , Bo Yuan

Deep learning-based medical image analysis faces a significant barrier due to the lack of interpretability. Conventional explainable AI (XAI) techniques, such as Grad-CAM and SHAP, often highlight regions outside clinical interests. To…

Image and Video Processing · Electrical Eng. & Systems 2025-02-17 Yuhao Zhang , Mingcheng Zhu , Zhiyao Luo

Real-world multimodal applications often require any-to-any capabilities, enabling both understanding and generation across modalities including text, image, audio, and video. However, integrating the strengths of autoregressive language…

Machine Learning · Computer Science 2025-08-15 Jiulin Li , Ping Huang , Yexin Li , Shuo Chen , Juewen Hu , Ye Tian

Multidisciplinary team (MDT) consultations are the gold standard for cancer care decision-making, yet current practice lacks structured mechanisms for quantifying consensus and ensuring decision traceability. We introduce a Multi-Agent…

Multiagent Systems · Computer Science 2025-12-17 Xudong Han , Xianglun Gao , Xiaoyi Qu , Zhenyu Yu

As multi-agent AI systems evolve from simple chatbots to autonomous swarms, debugging semantic failures requires reasoning about knowledge, belief, causality, and obligation, precisely what modal logic was designed to formalize. However,…

Artificial Intelligence · Computer Science 2026-02-13 Antonin Sulc

Unlike most primary headaches, secondary headaches need specialized care and can have devastating consequences if not treated promptly. Clinical guidelines highlight several 'red flag' features, such as thunderclap onset, meningismus,…

Multimodal recommender systems leverage diverse data sources, such as user interactions, content features, and contextual information, to address challenges like cold-start and data sparsity. However, existing methods often suffer from one…

Information Retrieval · Computer Science 2026-02-24 Adamya Shyam , Venkateswara Rao Kagita , Bharti Rana , Vikas Kumar

The rise of Large Language Models (LLMs) has enabled the development of specialized AI agents with domain-specific reasoning and interaction capabilities, particularly in healthcare. While recent frameworks simulate medical decision-making,…

Artificial Intelligence · Computer Science 2025-07-04 Tianqi Shang , Weiqing He , Charles Zheng , Lingyao Li , Li Shen , Bingxin Zhao

Large Language Models (LLMs) have shown impressive performance on existing medical question-answering benchmarks. This high performance makes it increasingly difficult to meaningfully evaluate and differentiate advanced methods. We present…

Computation and Language · Computer Science 2025-03-21 Xiangru Tang , Daniel Shao , Jiwoong Sohn , Jiapeng Chen , Jiayi Zhang , Jinyu Xiang , Fang Wu , Yilun Zhao , Chenglin Wu , Wenqi Shi , Arman Cohan , Mark Gerstein

Mental health disorders represent a burgeoning global public health challenge. While Large Language Models (LLMs) have demonstrated potential in psychiatric assessment, their clinical utility is severely constrained by benchmarks that lack…

Artificial Intelligence · Computer Science 2026-02-04 Xiao Sun , Yuming Yang , Junnan Zhu , Jiang Zhong , Xinyu Zhou , Kaiwen Wei

Artificial intelligence has demonstrated significant potential in clinical decision-making; however, developing models capable of adapting to diverse real-world scenarios and performing complex diagnostic reasoning remains a major…

Computer Vision and Pattern Recognition · Computer Science 2025-08-18 Ronghao Xu , Zhen Huang , Yangbo Wei , Xiaoqian Zhou , Zikang Xu , Ting Liu , Zihang Jiang , S. Kevin Zhou

We introduce a novel large language model (LLM)-driven agent framework, which iteratively refines queries and filters contextual evidence by leveraging dynamically evolving knowledge. A defining feature of the system is its decoupling of…

Artificial Intelligence · Computer Science 2025-04-02 Seyoung Song

Chest X-ray (CXR) plays a pivotal role in clinical diagnosis, and a variety of task-specific and foundation models have been developed for automatic CXR interpretation. However, these models often struggle to adapt to new diagnostic tasks…

Artificial Intelligence · Computer Science 2025-10-27 Jinhui Lou , Yan Yang , Zhou Yu , Zhenqi Fu , Weidong Han , Qingming Huang , Jun Yu

With the rise of telemedicine, the task of developing Dialogue Systems for Medical Diagnosis (DSMD) has received much attention in recent years. Different from early researches that needed to rely on extra human resources and expertise to…

Computation and Language · Computer Science 2022-05-03 Wenge Liu , Yi Cheng , Hao Wang , Jianheng Tang , Yafei Liu , Ruihui Zhao , Wenjie Li , Yefeng Zheng , Xiaodan Liang

Precise surgical interventions are vital to patient safety, and advanced enhancement algorithms have been developed to assist surgeons in decision-making. Despite significant progress, these algorithms are typically designed for single…

Computer Vision and Pattern Recognition · Computer Science 2025-07-04 Zeyu Lei , Hongyuan Yu , Jinlin Wu , Zhen Chen

Deep reasoning is fundamental for solving complex tasks, especially in vision-centric scenarios that demand sequential, multimodal understanding. However, existing benchmarks typically evaluate agents with fully synthetic, single-turn…

Large Language Models (LLMs) demonstrate strong generalization and reasoning abilities, making them well-suited for complex decision-making tasks such as medical consultation (MC). However, existing LLM-based methods often fail to capture…

Computation and Language · Computer Science 2025-10-13 Zhihao Jia , Mingyi Jia , Junwen Duan , Jianxin Wang

We present a framework for training large language models (LLMs) as diagnostic agents with reinforcement learning, enabling them to manage multi-turn interactive diagnostic processes, adaptively select examinations, and commit to final…

Computation and Language · Computer Science 2026-02-11 Pengcheng Qiu , Chaoyi Wu , Junwei Liu , Qiaoyu Zheng , Yusheng Liao , Haowen Wang , Yun Yue , Qianrui Fan , Shuai Zhen , Jian Wang , Jinjie Gu , Yanfeng Wang , Ya Zhang , Weidi Xie

An effective healthcare agent must be able to recall and reason over a patient's longitudinal medical history. However, the absence of datasets with realistic long-term dialogue timelines limits systematic evaluation. Real clinical text is…

Computation and Language · Computer Science 2026-05-20 Hebin Hu , Renke Dai , Ah-Hwee Tan , Yilin Kang
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