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Experienced physicians develop diagnostic expertise through clinical practice, acquiring not only disease knowledge but also the ability to differentiate confusable conditions. Current medical vision-language models (VLMs) lack this…

Machine Learning · Computer Science 2026-05-25 Qianhan Feng , Zhongzhen Huang , Yakun Zhu , Yannian Gu , Winnie Chiu Wing Chu , Xiaofan Zhang , Qi Dou

Document Question Answering (DocQA) is a very common task. Existing methods using Large Language Models (LLMs) or Large Vision Language Models (LVLMs) and Retrieval Augmented Generation (RAG) often prioritize information from a single…

Machine Learning · Computer Science 2025-03-19 Siwei Han , Peng Xia , Ruiyi Zhang , Tong Sun , Yun Li , Hongtu Zhu , Huaxiu Yao

Large language models (LLMs), despite their remarkable progress across various general domains, encounter significant barriers in medicine and healthcare. This field faces unique challenges such as domain-specific terminologies and…

Computation and Language · Computer Science 2024-06-06 Xiangru Tang , Anni Zou , Zhuosheng Zhang , Ziming Li , Yilun Zhao , Xingyao Zhang , Arman Cohan , Mark Gerstein

Rare diseases affect over 300 million individuals worldwide, yet timely and accurate diagnosis remains an urgent challenge. Patients often endure a prolonged diagnostic odyssey exceeding five years, marked by repeated referrals,…

Computation and Language · Computer Science 2026-02-17 Weike Zhao , Chaoyi Wu , Yanjie Fan , Xiaoman Zhang , Pengcheng Qiu , Yuze Sun , Xiao Zhou , Yanfeng Wang , Xin Sun , Ya Zhang , Yongguo Yu , Kun Sun , Weidi Xie

Diagnosis-oriented dialogue system queries the patient's health condition and makes predictions about possible diseases through continuous interaction with the patient. A few studies use reinforcement learning (RL) to learn the optimal…

Computation and Language · Computer Science 2022-12-27 Wei Chen , Cheng Zhong , Jiajie Peng , Zhongyu Wei

Artificial intelligence holds great promise for expanding access to expert medical knowledge and reasoning. However, most evaluations of language models rely on static vignettes and multiple-choice questions that fail to reflect the…

Clinical diagnosis is a complex reasoning process in which clinicians gather evidence, form hypotheses, and test them against alternative explanations. In medical training, this reasoning is explicitly developed through counterfactual…

Computation and Language · Computer Science 2026-04-24 Zhiwen You , Xi Chen , Aniket Vashishtha , Simo Du , Gabriel Erion-Barner , Hongyuan Mei , Hao Peng , Yue Guo

While recent advancements in Large Language Models have significantly advanced dermatological diagnosis, monolithic LLMs frequently struggle with fine-grained, large-scale multi-class diagnostic tasks and rare skin disease diagnosis owing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Zhangtianyi Chen , Yuhao Shen , Florensia Widjaja , Yan Xu , Liyuan Sun , Zijian Wang , Hongyi Chen , Wufei Dai , Juexiao Zhou

Medical Large Vision-Language Models (Med-LVLMs) have been widely adopted for medical report generation. Despite Med-LVLMs producing state-of-the-art performance, they exhibit a bias toward predicting all findings as normal, leading to…

Multiagent Systems · Computer Science 2025-05-27 Pengyu Wang , Shuchang Ye , Usman Naseem , Jinman Kim

Medical document analysis plays a crucial role in extracting essential clinical insights from unstructured healthcare records, supporting critical tasks such as differential diagnosis. Determining the most probable condition among…

Artificial Intelligence · Computer Science 2025-06-25 Lei Kang , Xuanshuo Fu , Oriol Ramos Terrades , Javier Vazquez-Corral , Ernest Valveny , Dimosthenis Karatzas

Recent progress in multimodal large language models (MLLMs) has demonstrated promising performance on medical benchmarks and in preliminary trials as clinical assistants. Yet, our pilot audit of diagnostic cases uncovers a critical failure…

Artificial Intelligence · Computer Science 2025-09-30 Hongjun Liu , Yinghao Zhu , Yuhui Wang , Yitao Long , Zeyu Lai , Lequan Yu , Chen Zhao

Clinical diagnosis is a complex cognitive process, grounded in dynamic cue acquisition and continuous expertise accumulation. Yet most current artificial intelligence (AI) systems are misaligned with this reality, treating diagnosis as…

Artificial Intelligence · Computer Science 2026-03-12 Ruiyang Ren , Yuhao Wang , Yunsen Liang , Lan Luo , Jing Liu , Haifeng Wang , Cong Feng , Yinan Zhang , Chunyan Miao , Ji-Rong Wen , Wayne Xin Zhao

Combining pre-trained expert models offers substantial potential for scalable multimodal reasoning, but building a unified framework remains challenging due to the increasing diversity of input modalities and task complexity. For instance,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Shoubin Yu , Yue Zhang , Ziyang Wang , Jaehong Yoon , Mohit Bansal

Mental health assessment is crucial for early intervention and effective treatment, yet traditional clinician-based approaches are limited by the shortage of qualified professionals. Recent advances in artificial intelligence have sparked…

Computation and Language · Computer Science 2025-08-18 Jinpeng Hu , Ao Wang , Qianqian Xie , Hui Ma , Zhuo Li , Dan Guo

Despite the impressive capabilities of Large Language Models (LLMs), existing Conversational Health Agents (CHAs) remain static and brittle, incapable of adaptive multi-turn reasoning, symptom clarification, or transparent decision-making.…

Computation and Language · Computer Science 2025-07-11 Xinyi Liu , Dachun Sun , Yi R. Fung , Dilek Hakkani-Tür , Tarek Abdelzaher

The Mental Health Question Answer (MHQA) task requires the seeker and supporter to complete the support process in one-turn dialogue. Given the richness of help-seeker posts, supporters must thoroughly understand the content and provide…

Computation and Language · Computer Science 2025-01-28 Qi Chen , Dexi Liu

Paper weakness identification using single-agent or multi-agent LLMs has attracted increasing attention, yet existing approaches exhibit key limitations. Many multi-agent systems simulate human roles at a surface level, missing the…

Artificial Intelligence · Computer Science 2026-02-19 Zhuoyang Zou , Abolfazl Ansari , Delvin Ce Zhang , Dongwon Lee , Wenpeng Yin

Large language models (LLMs) struggle in real-world clinical consultations. Single-turn consultation systems require patients to describe all symptoms at once, which often leads to unclear complaints and vague diagnoses. Traditional…

Computation and Language · Computer Science 2026-05-01 Yichun Feng , Jiawei Wang , Lu Zhou , Yikai Zheng , Zhen Lei , Yixue Li

This paper presents an innovative large language model (LLM) agent framework for enhancing diagnostic accuracy in simulated clinical environments using the AgentClinic benchmark. The proposed automatic correction enables doctor agents to…

Artificial Intelligence · Computer Science 2024-10-15 Abhishek Dutta , Yen-Che Hsiao

Healthcare decision-making represents one of the most challenging domains for Artificial Intelligence (AI), requiring the integration of diverse knowledge sources, complex reasoning, and various external analytical tools. Current AI systems…

Computation and Language · Computer Science 2025-06-03 Yexiao He , Ang Li , Boyi Liu , Zhewei Yao , Yuxiong He