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Foundation model, which is pre-trained on broad data and is able to adapt to a wide range of tasks, is advancing healthcare. It promotes the development of healthcare artificial intelligence (AI) models, breaking the contradiction between…

Computers and Society · Computer Science 2024-04-05 Yuting He , Fuxiang Huang , Xinrui Jiang , Yuxiang Nie , Minghao Wang , Jiguang Wang , Hao Chen

Recent years have witnessed a surge in the development of protein foundation models, significantly improving performance in protein prediction and generative tasks ranging from 3D structure prediction and protein design to conformational…

Quantitative Methods · Quantitative Biology 2024-10-08 Fei Ye , Zaixiang Zheng , Dongyu Xue , Yuning Shen , Lihao Wang , Yiming Ma , Yan Wang , Xinyou Wang , Xiangxin Zhou , Quanquan Gu

Progress in Prognostics and Health Management (PHM) is hindered by the lack of standardized and reusable evaluation practices across tasks, datasets, and application domains. Reported results are often difficult to reproduce and compare, as…

Artificial Intelligence · Computer Science 2026-05-28 Lev Telyatnikov , Raffael Theiler , Leandro Von Krannichfeldt , Olga Fink

Pathology foundation models (PFMs) achieve strong performance on diverse histopathology tasks, but their sensitivity to hospital-specific domain shifts remains underexplored. We systematically evaluate state-of-the-art PFMs on TCGA…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Mengliang Zhang

Using LLMs in healthcare, Computer-Supported Cooperative Work, and Social Computing requires the examination of ethical and social norms to ensure safe incorporation into human life. We conducted a mixed-method study, including an online…

Computers and Society · Computer Science 2025-04-28 Omid Veisi , Sasan Bahrami , Roman Englert , Claudia Müller

Knowing the uncertainty in a prediction is critical when making expensive investment decisions and when patient safety is paramount, but machine learning (ML) models in drug discovery typically provide only a single best estimate and ignore…

Machine Learning · Computer Science 2021-06-03 Stanley E. Lazic , Dominic P. Williams

As large language models (LLMs) develop increasingly sophisticated capabilities and find applications in medical settings, it becomes important to assess their medical safety due to their far-reaching implications for personal and public…

Artificial Intelligence · Computer Science 2024-10-11 Tessa Han , Aounon Kumar , Chirag Agarwal , Himabindu Lakkaraju

While Medical Large Language Models (MedLLMs) have demonstrated remarkable potential in clinical tasks, their ethical safety remains insufficiently explored. This paper introduces $\textbf{MedEthicsQA}$, a comprehensive benchmark comprising…

Computation and Language · Computer Science 2025-07-01 Jianhui Wei , Zijie Meng , Zikai Xiao , Tianxiang Hu , Yang Feng , Zhijie Zhou , Jian Wu , Zuozhu Liu

Foundation Models (FMs) display exceptional performance in tasks such as natural language processing and are being applied across a growing range of disciplines. Although typically trained on large public datasets, FMs are often fine-tuned…

Cryptography and Security · Computer Science 2024-10-10 Marcin Chrapek , Anjo Vahldiek-Oberwagner , Marcin Spoczynski , Scott Constable , Mona Vij , Torsten Hoefler

Accurate molecular property prediction is central to drug discovery, catalysis, and process design, yet real-world applications are often limited by small datasets. Molecular foundation models provide a promising direction by learning…

Machine Learning · Computer Science 2026-04-21 Karim K. Ben Hicham , Jan G. Rittig , Martin Grohe , Alexander Mitsos

Wearable devices that measure and record physiological signals are now becoming widely available to the general public with ever-increasing affordability and signal quality. The data from these devices introduce serious ethical challenges…

Computers and Society · Computer Science 2024-05-27 Keith Davis , Tuukka Ruotsalo

Generalist pathology foundation models (PFMs), pretrained on large-scale multi-organ datasets, have demonstrated remarkable predictive capabilities across diverse clinical applications. However, their proficiency on the full spectrum of…

Machine learning is expected to fuel significant improvements in medical care. To ensure that fundamental principles such as beneficence, respect for human autonomy, prevention of harm, justice, privacy, and transparency are respected,…

Medical Large Language Models (LLMs) are increasingly deployed for clinical decision support across diverse specialties, yet systematic evaluation of their robustness to adversarial misuse and privacy leakage remains inaccessible to most…

Cryptography and Security · Computer Science 2025-12-10 Jinghao Wang , Ping Zhang , Carter Yagemann

Foundation models (FMs) are large-scale deep learning models trained on massive datasets, often using self-supervised learning techniques. These models serve as a versatile base for a wide range of downstream tasks, including those in…

Machine Learning · Computer Science 2025-01-17 Wasif Khan , Seowung Leem , Kyle B. See , Joshua K. Wong , Shaoting Zhang , Ruogu Fang

In recent years, the idea of formalising and modelling fairness for algorithmic decision making (ADM) has advanced to a point of sophisticated specialisation. However, the relations between technical (formalised) and ethical discourse on…

Machine Learning · Computer Science 2022-03-14 Pola Schwöbel , Peter Remmers

Premise. Patterns of electrical brain activity recorded via electroencephalography (EEG) offer immense value for scientific and clinical investigations. The inability of supervised EEG encoders to learn robust EEG patterns and their…

Signal Processing · Electrical Eng. & Systems 2025-12-25 Gayal Kuruppu , Neeraj Wagh , Vaclav Kremen , Sandipan Pati , Gregory Worrell , Yogatheesan Varatharajah

Foundation models (FMs) have demonstrated strong transferability across medical imaging tasks, yet their clinical utility depends critically on how pretrained representations are adapted to domain-specific data, supervision regimes, and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Karma Phuntsho , Abdullah , Kyungmi Lee , Ickjai Lee , Euijoon Ahn

Foundation models (FMs) are changing the way medical images are analyzed by learning from large collections of unlabeled data. Instead of relying on manually annotated examples, FMs are pre-trained to learn general-purpose visual features…

Early diagnosis of diseases holds the potential for deep transformation in healthcare by enabling better treatment options, improving long-term survival and quality of life, and reducing overall cost. With the advent of medical big data,…

Machine Learning · Computer Science 2023-11-29 Tim Schubert , Richard W Peck , Alexander Gimson , Camelia Davtyan , Mihaela van der Schaar
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