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Foundational models (FMs) have tremendous potential to revolutionize medical imaging. However, their deployment in real-world clinical settings demands extensive ethical considerations. This paper aims to highlight the ethical concerns…

Computers and Society · Computer Science 2024-06-19 Abhijit Das , Debesh Jha , Jasmer Sanjotra , Onkar Susladkar , Suramyaa Sarkar , Ashish Rauniyar , Nikhil Tomar , Vanshali Sharma , Ulas Bagci

Computational pathology, which involves analyzing whole slide images for automated cancer diagnosis, relies on multiple instance learning, where performance depends heavily on the feature extractor and aggregator. Recent Pathology…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Conghao Xiong , Hao Chen , Joseph J. Y. Sung

Pathology foundation models (PFMs) have rapidly advanced and are becoming a common backbone for downstream clinical tasks, offering strong transferability across tissues and institutions. However, for dense prediction (e.g., segmentation),…

Image and Video Processing · Electrical Eng. & Systems 2026-02-05 Weiming Chen , Xitong Ling , Xidong Wang , Zhenyang Cai , Yijia Guo , Mingxi Fu , Ziyi Zeng , Minxi Ouyang , Jiawen Li , Yizhi Wang , Tian Guan , Benyou Wang , Yonghong He

Foundational Models (FMs) are gaining increasing attention in the biomedical AI ecosystem due to their ability to represent and contextualize multimodal biomedical data. These capabilities make FMs a valuable tool for a variety of tasks,…

Computational pathology foundation models (CPathFMs) have emerged as a powerful approach for analyzing histopathological data, leveraging self-supervised learning to extract robust feature representations from unlabeled whole-slide images.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-27 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Ajit J. Nirmal , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

The emergence of pathology foundation models has revolutionized computational histopathology, enabling highly accurate, generalized whole-slide image analysis for improved cancer diagnosis, and prognosis assessment. While these models show…

Biomedical Foundation Models (FMs) are rapidly transforming AI-enabled healthcare research and entering clinical validation. However, their susceptibility to learning non-biological technical features -- including variations in…

The rapid advancement of foundation models in medical imaging represents a significant leap toward enhancing diagnostic accuracy and personalized treatment. However, the deployment of foundation models in healthcare necessitates a rigorous…

Computer Vision and Pattern Recognition · Computer Science 2024-10-08 Congzhen Shi , Ryan Rezai , Jiaxi Yang , Qi Dou , Xiaoxiao Li

Pathology foundation models (PFMs) have emerged as powerful pretrained encoders for computational pathology, but their robustness under clinically relevant distribution shifts remains insufficiently understood. We benchmark the robustness…

Image and Video Processing · Electrical Eng. & Systems 2026-04-29 Fredrik K. Gustafsson , Mattias Rantalainen

Pathology foundation models (PFMs) have recently emerged as powerful pretrained encoders for computational pathology, enabling transfer learning across a wide range of downstream tasks. However, systematic comparisons of these models for…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Fredrik K. Gustafsson , Constance Boissin , Johan Vallon-Christersson , David A. Clifton , Mattias Rantalainen

The advent of foundation models (FMs) in healthcare offers unprecedented opportunities to enhance medical diagnostics through automated classification and segmentation tasks. However, these models also raise significant concerns about their…

Computer Vision and Pattern Recognition · Computer Science 2024-12-09 Ruinan Jin , Zikang Xu , Yuan Zhong , Qiongsong Yao , Qi Dou , S. Kevin Zhou , Xiaoxiao Li

The deployment of large language models (LLMs) in mental health and other sensitive domains raises urgent questions about ethical reasoning, fairness, and responsible alignment. Yet, existing benchmarks for moral and clinical…

Computation and Language · Computer Science 2025-09-16 Sai Kartheek Reddy Kasu

In a previous work, we introduced the fuzzy Ethical Decision-Making framework (fEDM), a risk-based ethical reasoning architecture grounded in fuzzy logic. The original model combined a fuzzy Ethical Risk Assessment module (fERA) with…

Artificial Intelligence · Computer Science 2026-03-02 Abeer Dyoub , Francesca A. Lisi

Foundation models (FMs) have emerged as a transformative paradigm in medical image analysis, offering the potential to provide generalizable, task-agnostic solutions across a wide range of clinical tasks and imaging modalities. Their…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Karma Phuntsho , Abdullah , Kyungmi Lee , Ickjai Lee , Euijoon Ahn

Background: As large language models (LLMs) are increasingly used in healthcare and medical consultation settings, a growing concern is whether these models can respond to medical inquiries in a manner that is ethically…

Computers and Society · Computer Science 2026-02-02 Hanhui Xu , Jiacheng Ji , Haoan Jin , Han Ying , Mengyue Wu

Understanding the inner mechanisms of black-box foundation models (FMs) is essential yet challenging in artificial intelligence and its applications. Over the last decade, the long-running focus has been on their explainability, leading to…

Machine Learning · Computer Science 2024-11-26 Shi Fu , Yuzhu Chen , Yingjie Wang , Dacheng Tao

Pathology Foundation Models (FMs) hold great promise for healthcare. Before they can be used in clinical practice, it is essential to ensure they are robust to variations between medical centers. We measure whether pathology FMs focus on…

Machine Learning · Computer Science 2025-02-04 Edwin D. de Jong , Eric Marcus , Jonas Teuwen

The application of large language models (LLMs) in healthcare holds significant promise for enhancing clinical decision-making, medical research, and patient care. However, their integration into real-world clinical settings raises critical…

Computers and Society · Computer Science 2025-09-18 Manar Aljohani , Jun Hou , Sindhura Kommu , Xuan Wang

Pathology has played a crucial role in the diagnosis and evaluation of patient tissue samples obtained from surgeries and biopsies for many years. The advent of Whole Slide Scanners and the development of deep learning technologies have…

Computer Vision and Pattern Recognition · Computer Science 2024-08-07 Mieko Ochi , Daisuke Komura , Shumpei Ishikawa

Quantum information technologies, covering quantum computing, quantum communication and quantum sensing, are among the most significant technologies to emerge in recent decades, offering the promise of paradigm-shifting computational…

Quantum Physics · Physics 2022-04-21 Elija Perrier
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