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This survey paper outlines the key developments in the field of Large Language Models (LLMs), including enhancements to their reasoning skills, adaptability to various tasks, increased computational efficiency, and the ability to make…

Computation and Language · Computer Science 2026-02-12 Asifullah Khan , Muhammad Zaeem Khan , Aleesha Zainab , Saleha Jamshed , Sadia Ahmad , Kaynat Khatib , Faria Bibi , Abdul Rehman

The rapid growth of biomedical knowledge has outpaced our ability to efficiently extract insights and generate novel hypotheses. Large language models (LLMs) have emerged as a promising tool to revolutionize knowledge interaction and…

Computation and Language · Computer Science 2024-07-16 Biqing Qi , Kaiyan Zhang , Kai Tian , Haoxiang Li , Zhang-Ren Chen , Sihang Zeng , Ermo Hua , Hu Jinfang , Bowen Zhou

This paper explores the intersection of psychology and artificial intelligence through the development and evaluation of specialized Large Language Models (LLMs). We introduce PsychoLex, a suite of resources designed to enhance LLMs'…

Computation and Language · Computer Science 2024-08-19 Mohammad Amin Abbasi , Farnaz Sadat Mirnezami , Hassan Naderi

Large language models (LLMs) such as ChatGPT have gained considerable interest across diverse research communities. Their notable ability for text completion and generation has inaugurated a novel paradigm for language-interfaced problem…

Quantitative Methods · Quantitative Biology 2024-02-22 Hengchuang Yin , Zhonghui Gu , Fanhao Wang , Yiparemu Abuduhaibaier , Yanqiao Zhu , Xinming Tu , Xian-Sheng Hua , Xiao Luo , Yizhou Sun

Understanding the behavior of large language models (LLMs) is crucial for ensuring their safe and reliable use. However, existing explainable AI (XAI) methods for LLMs primarily rely on word-level explanations, which are often…

Computation and Language · Computer Science 2025-08-08 Furui Cheng , Vilém Zouhar , Robin Shing Moon Chan , Daniel Fürst , Hendrik Strobelt , Mennatallah El-Assady

The proliferation of Large Language Models (LLMs) in medicine has enabled impressive capabilities, yet a critical gap remains in their ability to perform systematic, transparent, and verifiable reasoning, a cornerstone of clinical practice.…

Computation and Language · Computer Science 2025-08-04 Wenxuan Wang , Zizhan Ma , Meidan Ding , Shiyi Zheng , Shengyuan Liu , Jie Liu , Jiaming Ji , Wenting Chen , Xiang Li , Linlin Shen , Yixuan Yuan

There are two main barriers to using large language models (LLMs) in clinical reasoning. Firstly, while LLMs exhibit significant promise in Natural Language Processing (NLP) tasks, their performance in complex reasoning and planning falls…

Artificial Intelligence · Computer Science 2024-12-31 Shengxin Hong , Liang Xiao , Xin Zhang , Jianxia Chen

Existing Protein Language Models (PLMs) often suffer from limited adaptability to multiple tasks and exhibit poor generalization across diverse biological contexts. In contrast, general-purpose Large Language Models (LLMs) lack the…

Machine Learning · Computer Science 2026-02-23 Yujia Wang , Jihong Guan , Wengen Li , Shuigeng Zhou , Xuhong Wang

Mental health is increasingly critical in contemporary healthcare, with psychotherapy demanding dynamic, context-sensitive interactions that traditional NLP methods struggle to capture. Large Language Models (LLMs) offer significant…

Computation and Language · Computer Science 2025-06-30 Hongbin Na , Yining Hua , Zimu Wang , Tao Shen , Beibei Yu , Lilin Wang , Wei Wang , John Torous , Ling Chen

Large Language Models (LLMs) and LLM-based agents show great promise in accelerating scientific research. Existing benchmarks for measuring this potential and guiding future development continue to evolve from pure recall and rote knowledge…

This paper investigates the capabilities of large language models (LLMs) in formulating and solving decision-making problems using mathematical programming. We first conduct a systematic review and meta-analysis of recent literature to…

Artificial Intelligence · Computer Science 2025-08-26 Mohammad J. Abdel-Rahman , Yasmeen Alslman , Dania Refai , Amro Saleh , Malik A. Abu Loha , Mohammad Yahya Hamed

Generating accurate step-by-step reasoning is essential for Large Language Models (LLMs) to address complex problems and enhance robustness and interpretability. Despite the flux of research on developing advanced reasoning approaches,…

Computation and Language · Computer Science 2024-08-13 Shibo Hao , Yi Gu , Haotian Luo , Tianyang Liu , Xiyan Shao , Xinyuan Wang , Shuhua Xie , Haodi Ma , Adithya Samavedhi , Qiyue Gao , Zhen Wang , Zhiting Hu

Large Language Models (LLMs) have demonstrated remarkable capabilities in challenging, knowledge-intensive reasoning tasks. However, extending LLMs to perceive and reason over a new modality (e.g., vision), often requires costly development…

Computation and Language · Computer Science 2025-11-25 James Y. Huang , Sheng Zhang , Qianchu Liu , Guanghui Qin , Tinghui Zhu , Tristan Naumann , Muhao Chen , Hoifung Poon

With the development of artificial intelligence (AI), large language models (LLM) are widely used in many fields. However, the reasoning ability of LLM is still very limited when it comes to mathematical reasoning. Mathematics plays an…

Computation and Language · Computer Science 2024-08-06 Wenbei Xie , Donglin Liu , Haoran Yan , Wenjie Wu , Zongyang Liu

Traditional base station siting (BSS) methods rely heavily on drive testing and user feedback, which are laborious and require extensive expertise in communication, networking, and optimization. As large language models (LLMs) and their…

Artificial Intelligence · Computer Science 2024-12-30 Yanhu Wang , Muhammad Muzammil Afzal , Zhengyang Li , Jie Zhou , Chenyuan Feng , Shuaishuai Guo , Tony Q. S. Quek

Large Language Model (LLM) Agents exhibit inherent reasoning abilities through the collaboration of multiple tools. However, during agent inference, existing methods often suffer from (i) locally myopic generation, due to the absence of…

Artificial Intelligence · Computer Science 2026-01-15 Jian Zhang , Zhiyuan Wang , Zhangqi Wang , Yu He , Haoran Luo , li yuan , Lingling Zhang , Rui Mao , Qika Lin , Jun Liu

Pathology is experiencing rapid digital transformation driven by whole-slide imaging and artificial intelligence (AI). While deep learning-based computational pathology has achieved notable success, traditional models primarily focus on…

This paper surveys the development of large language model (LLM)-based agents for question answering (QA). Traditional agents face significant limitations, including substantial data requirements and difficulty in generalizing to new…

Computation and Language · Computer Science 2025-03-26 Murong Yue

The applications of large language models (LLMs) are promising for biomedical and healthcare research. Despite the availability of open-source LLMs trained using a wide range of biomedical data, current research on the applications of LLMs…

Machine Learning · Computer Science 2024-09-25 Tianyu Liu , Yijia Xiao , Xiao Luo , Hua Xu , W. Jim Zheng , Hongyu Zhao

Large language models (LLMs) such as ChatGPT o1, ChatGPT o3, and DeepSeek R1 have shown great potential in solving difficult problems. However, current LLM evaluation benchmarks are limited to one-step interactions. Some of the existing…

Machine Learning · Computer Science 2025-12-01 Huanyu Li , Zongyuan Li , Wei Huang , Xian Guo
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