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Cryo-EM is a vital technique for determining 3D structure of biological molecules such as proteins and viruses. The cryo-EM reconstruction problem is challenging due to the high noise levels, the missing poses of particles, and the…

Quantitative Methods · Quantitative Biology 2024-06-05 Larissa de Ruijter , Gabriele Cesa

Structural flexibility and/or dynamic interactions with other molecules is a critical aspect of protein function. CryoEM provides direct visualization of individual macromolecules sampling different conformational and compositional states.…

Biomolecules · Quantitative Biology 2021-08-04 Muyuan Chen , Steven Ludtke

Image segmentation is widely used in a variety of computer vision tasks, such as object localization and recognition, boundary detection, and medical imaging. This thesis proposes deep learning architectures to improve automatic object…

Image and Video Processing · Electrical Eng. & Systems 2019-09-24 Debleena Sengupta

Single-particle cryo-electron microscopy (cryo-EM) is an emerging imaging modality capable of visualizing proteins and macro-molecular complexes at near-atomic resolution. The low electron-doses used to prevent sample radiation damage,…

Image and Video Processing · Electrical Eng. & Systems 2020-11-24 Qinwen Huang , Ye Zhou , Xiaochen Du , Reed Chen , Jianyou Wang , Cynthia Rudin , Alberto Bartesaghi

Protein structure prediction models are now capable of generating accurate 3D structural hypotheses from sequence alone. However, they routinely fail to capture the conformational diversity of dynamic biomolecular complexes, often requiring…

Machine Learning · Computer Science 2025-12-02 Rishwanth Raghu , Axel Levy , Gordon Wetzstein , Ellen D. Zhong

Cryo-electron microscopy (cryo-EM) is a widely used technique for recovering the 3-D structure of biological molecules from a large number of experimentally generated noisy 2-D tomographic projection images of the 3-D structure, taken from…

Numerical Analysis · Mathematics 2025-11-17 Jeremy Hoskins , Yuehaw Khoo , Oscar Mickelin , Amit Singer , Yuguan Wang

Object Skeletonization is the process of extracting skeletal, line-like representations of shapes. It provides a very useful tool for geometric shape understanding and minimal shape representation. It also has a wide variety of…

Computer Vision and Pattern Recognition · Computer Science 2021-12-23 Mohamed A. Ghanem , Alaa A. Anani

Understanding the structure of a protein complex is crucial indetermining its function. However, retrieving accurate 3D structures from microscopy images is highly challenging, particularly as many imaging modalities are two-dimensional.…

Quantitative Methods · Quantitative Biology 2021-10-18 Benjamin J. Blundell , Christian Sieben , Suliana Manley , Ed Rosten , QueeLim Ch'ng , Susan Cox

In order to function in unstructured environments, robots need the ability to recognize unseen objects. We take a step in this direction by tackling the problem of segmenting unseen object instances in tabletop environments. However, the…

Computer Vision and Pattern Recognition · Computer Science 2021-10-15 Christopher Xie , Yu Xiang , Arsalan Mousavian , Dieter Fox

i-TED is an innovative detection system which exploits Compton imaging techniques to achieve a superior signal-to-background ratio in ($n,\gamma$) cross-section measurements using time-of-flight technique. This work presents the first…

Instrumentation and Detectors · Physics 2024-10-17 V. Babiano-Suárez , J. Lerendegui-Marco , J. Balibrea-Correa , L. Caballero , D. Calvo , I. Ladarescu , C. Domingo-Pardo , F. Calviño , A. Casanovas , A. Tarifeño-Saldivia , V. Alcayne , C. Guerrero , M. A. Millán-Callado , M. T. Rodríguez González , M. Barbagallo , O. Aberle , S. Amaducci , J. Andrzejewski , L. Audouin , M. Bacak , S. Bennett , E. Berthoumieux , J. Billowes , D. Bosnar , A. Brown , M. Busso , M. Caamaño , M. Calviani , D. Cano-Ott , F. Cerutti , E. Chiaveri , N. Colonna , G. Cortés , M. A. Cortés-Giraldo , L. Cosentino , S. Cristallo , L. A. Damone , P. J. Davies , M. Diakaki , M. Dietz , R. Dressler , Q. Ducasse , E. Dupont , I. Durán , Z. Eleme , B. Fern\' , ez-Domínguez , A. Ferrari , P. Finocchiaro , V. Furman , K. Göbel , R. Garg , A. Gawlik , S. Gilardoni , I. F. Gonçalves , E. González-Romero , F. Gunsing , H. Harada , S. Heinitz , J. Heyse , D. G. Jenkins , A. Junghans , F. Käppeler , Y. Kadi , A. Kimura , I. Knapova , M. Kokkoris , Y. Kopatch , M. Krtička , D. Kurtulgil , C. Lederer-Woods , H. Leeb , S. J. Lonsdale , D. Macina , A. Manna , T. Martinez , A. Masi , C. Massimi , P. Mastinu , M. Mastromarco , E. A. Maugeri , A. Mazzone , E. Mendoza , A. Mengoni , V. Michalopoulou , P. M. Milazzo , F. Mingrone , J. Moreno-Soto , A. Musumarra , A. Negret , F. Ogállar , A. Oprea , N. Patronis , A. Pavlik , J. Perkowski , L. Persanti , C. Petrone , E. Pirovano , I. Porras , J. Praena , J. M. Quesada , D. Ramos-Doval , T. Rauscher , R. Reifarth , D. Rochman , C. Rubbia , M. Sabaté-Gilarte , A. Saxena , P. Schillebeeckx , D. Schumann , A. Sekhar , A. G. Smith , N. V. Sosnin , P. Sprung , A. Stamatopoulos , G. Tagliente , J. L. Tain , L. Tassan-Got , Th. Thomas , P. Torres-Sánchez , A. Tsinganis , J. Ulrich , S. Urlass , S. Valenta , G. Vannini , V. Variale , P. Vaz , A. Ventura , D. Vescovi , V. Vlachoudis , R. Vlastou , A. Wallner , P. J. Woods , T. Wright , P. Žugec

Recent advances in camera equipped drone applications and their widespread use increased the demand on vision based object detection algorithms for aerial images. Object detection process is inherently a challenging task as a generic…

Computer Vision and Pattern Recognition · Computer Science 2020-12-25 Berat Mert Albaba , Sedat Ozer

We introduce CenDerNet, a framework for 6D pose estimation from multi-view images based on center and curvature representations. Finding precise poses for reflective, textureless objects is a key challenge for industrial robotics. Our…

Computer Vision and Pattern Recognition · Computer Science 2022-08-24 Peter De Roovere , Rembert Daems , Jonathan Croenen , Taoufik Bourgana , Joris de Hoog , Francis Wyffels

Understanding 3D object structure from a single image is an important but challenging task in computer vision, mostly due to the lack of 3D object annotations to real images. Previous research tackled this problem by either searching for a…

Computer Vision and Pattern Recognition · Computer Science 2019-08-13 Jiajun Wu , Tianfan Xue , Joseph J. Lim , Yuandong Tian , Joshua B. Tenenbaum , Antonio Torralba , William T. Freeman

Curvilinear structure segmentation is important in medical imaging, quantifying structures such as vessels, airways, neurons, or organ boundaries in 2D slices. Segmentation via pixel-wise classification often fails to capture the small and…

Image and Video Processing · Electrical Eng. & Systems 2023-03-07 Manxi Lin , Zahra Bashir , Martin Grønnebæk Tolsgaard , Anders Nymark Christensen , Aasa Feragen

Atomic electron tomography (AET) enables the determination of 3D atomic structures by acquiring a sequence of 2D tomographic projection measurements of a particle and then computationally solving for its underlying 3D representation.…

Image and Video Processing · Electrical Eng. & Systems 2025-12-18 Nalini M. Singh , Tiffany Chien , Arthur R. C. McCray , Colin Ophus , Laura Waller

Finding correspondences between images or 3D scans is at the heart of many computer vision and image retrieval applications and is often enabled by matching local keypoint descriptors. Various learning approaches have been applied in the…

Computer Vision and Pattern Recognition · Computer Science 2018-05-10 Georgios Georgakis , Srikrishna Karanam , Ziyan Wu , Jan Ernst , Jana Kosecka

Cryo-EM is a powerful tool for understanding macromolecular structures, yet current methods for structure reconstruction are slow and computationally demanding. To accelerate research on pose estimation, we present CESPED, a new dataset…

Quantitative Methods · Quantitative Biology 2024-05-03 Ruben Sanchez-Garcia , Michael Saur , Javier Vargas , Carl Poelking , Charlotte M Deane

Cryogenic electron microscopy (cryo-EM) provides a unique opportunity to study the structural heterogeneity of biomolecules. Being able to explain this heterogeneity with atomic models would help our understanding of their functional…

Quantitative analysis of microstructural features on the nanoscale, including precipitates, local chemical orderings (LCOs) or structural defects (e.g. stacking faults) plays a pivotal role in understanding the mechanical and physical…

Detection and classification of objects in aerial imagery have several applications like urban planning, crop surveillance, and traffic surveillance. However, due to the lower resolution of the objects and the effect of noise in aerial…

Computer Vision and Pattern Recognition · Computer Science 2019-08-23 Dheeraj Reddy Pailla , Varghese Kollerathu , Sai Saketh Chennamsetty
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