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Determining the primary site of origin for metastatic tumors is one of the open problems in cancer care because the efficacy of treatment often depends on the cancer tissue of origin. Classification methods that can leverage tumor genomic…

Genomics · Quantitative Biology 2019-11-19 Alena Harley

The class distribution of data is one of the factors that regulates the performance of machine learning models. However, investigations on the impact of different distributions available in the literature are very few, sometimes absent for…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Ismat Ara Reshma , Sylvain Cussat-Blanc , Radu Tudor Ionescu , Hervé Luga , Josiane Mothe

Assessing microsatellite stability status of a patient's colorectal cancer is crucial in personalizing treatment regime. Recently, convolutional-neural-networks (CNN) combined with transfer-learning approaches were proposed to circumvent…

Computer Vision and Pattern Recognition · Computer Science 2022-08-23 Daniel Shats , Hadar Hezi , Guy Shani , Yosef E. Maruvka , Moti Freiman

Gastric diffuse-type adenocarcinoma represents a disproportionately high percentage of cases of gastric cancers occurring in the young, and its relative incidence seems to be on the rise. Usually it affects the body of the stomach, and…

Image and Video Processing · Electrical Eng. & Systems 2021-04-27 Fahdi Kanavati , Masayuki Tsuneki

An important problem in deep learning is the privacy and security of neural networks (NNs). Both aspects have long been considered separately. To date, it is still poorly understood how privacy enhancing training affects the robustness of…

Cryptography and Security · Computer Science 2021-05-18 Franziska Boenisch , Philip Sperl , Konstantin Böttinger

Lung cancer is a very deadly disease worldwide, and its early diagnosis is crucial for increasing patient survival rates. Computed tomography (CT) scans are widely used for lung cancer diagnosis as they can give detailed lung structures.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-04 Md Rashidul Islam , Bakary Gibba , Altagi Abdallah Bakheit Abdelgadir

Personalized privacy becomes critical in deep learning for Trustworthy AI. While Differentially Private Stochastic Gradient Descent (DP-SGD) is widely used in deep learning methods supporting privacy, it provides the same level of privacy…

Machine Learning · Computer Science 2023-05-25 Geon Heo , Junseok Seo , Steven Euijong Whang

Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are…

Machine Learning · Statistics 2018-06-28 Jens Behrmann , Christian Etmann , Tobias Boskamp , Rita Casadonte , Jörg Kriegsmann , Peter Maass

Deep learning (DL) has been increasingly applied in medical imaging, however, it requires large amounts of data, which raises many challenges related to data privacy, storage, and transfer. Federated learning (FL) is a training paradigm…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Jan Fiszer , Dominika Ciupek , Maciej Malawski

Tumor growth prediction, a highly challenging task, has long been viewed as a mathematical modeling problem, where the tumor growth pattern is personalized based on imaging and clinical data of a target patient. Though mathematical models…

Computer Vision and Pattern Recognition · Computer Science 2017-06-05 Ling Zhang , Le Lu , Ronald M. Summers , Electron Kebebew , Jianhua Yao

Deep Learning (DL) can predict biomarkers from cancer histopathology. Several clinically approved applications use this technology. Most approaches, however, predict categorical labels, whereas biomarkers are often continuous measurements.…

With the rise in importance of personalized medicine, we trained personalized neural networks to detect tumor progression in longitudinal datasets. The model was evaluated on two datasets with a total of 64 scans from 32 patients diagnosed…

Machine Learning · Computer Science 2022-10-28 Christian Strack , Kelsey L. Pomykala , Heinz-Peter Schlemmer , Jan Egger , Jens Kleesiek

Since the emergence of the ImageNet dataset, the pretraining and fine-tuning approach has become widely adopted in computer vision due to the ability of ImageNet-pretrained models to learn a wide variety of visual features. However, a…

Computer Vision and Pattern Recognition · Computer Science 2024-10-22 Pablo Meseguer , Rocío del Amor , Adrian Colomer , Valery Naranjo

Machine Learning (ML) alleviates the challenges of high-dimensional data analysis and improves decision making in critical applications like healthcare. Effective cancer type from high-dimensional genetic mutation data can be useful for…

Cryptography and Security · Computer Science 2022-04-13 Esha Sarkar , Eduardo Chielle , Gamze Gursoy , Leo Chen , Mark Gerstein , Michail Maniatakos

We suggest that deep learning can be used for pre-screening cancer by analyzing demographic and anthropometric information of patients, as well as biological markers obtained from routine blood samples and relative risks obtained from…

Machine Learning · Statistics 2023-02-07 Rolando Gonzales Martinez , Daan-Max van Dongen

Melanoma diagnosed and treated in its early stages can increase the survival rate. A projected increase in skin cancer incidents and a dearth of dermatopathologists have emphasized the need for computational pathology (CPATH) systems. CPATH…

Image and Video Processing · Electrical Eng. & Systems 2023-11-07 Neel Kanwal , Roger Amundsen , Helga Hardardottir , Luca Tomasetti , Erling Sandoy Undersrud , Emiel A. M. Janssen , Kjersti Engan

Metastasis is the leading cause of cancer-related mortality, yet most predictive models rely on shallow architectures and neglect patient-specific regulatory mechanisms. Here, we integrate classical machine learning and deep learning to…

Other Quantitative Biology · Quantitative Biology 2025-12-29 Jiwei Fu , Chunyu Yang

Accurate characterization of glioma is crucial for clinical decision making. A delineation of the tumor is also desirable in the initial decision stages but is a time-consuming task. Leveraging the latest GPU capabilities, we developed a…

Precise breast cancer classification on histopathological images has the potential to greatly improve the diagnosis and patient outcome in oncology. The data imbalance problem largely stems from the inherent imbalance within medical image…

Image and Video Processing · Electrical Eng. & Systems 2024-11-28 Majid Behzadpour , Bengie L. Ortiz , Ebrahim Azizi , Kai Wu

Privacy-preserving machine learning aims to train models on private data without leaking sensitive information. Differential privacy (DP) is considered the gold standard framework for privacy-preserving training, as it provides formal…