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Microsatellite instability (MSI) is a tumor phenotype whose diagnosis largely impacts patient care in colorectal cancers (CRC), and is associated with response to immunotherapy in all solid tumors. Deep learning models detecting MSI tumors…

Image and Video Processing · Electrical Eng. & Systems 2022-03-23 Charlie Saillard , Olivier Dehaene , Tanguy Marchand , Olivier Moindrot , Aurélie Kamoun , Benoit Schmauch , Simon Jegou

The accurate diagnosis and molecular profiling of colorectal cancers are critical for planning the best treatment options for patients. Microsatellite instability (MSI) or mismatch repair (MMR) status plays a vital role in appropriate…

Quantitative Methods · Quantitative Biology 2022-04-27 Ruqayya Awan , Mohammed Nimir , Shan E Ahmed Raza , Mohsin Bilal , Johannes Lotz , David Snead , Andrew Robinson , Nasir Rajpoot

In this work, a modified ResNet model is proposed for the classification of Microsatellite instability(MSI) and Microsatellite stability(MSS) of gastrointestinal cancer. The performance of this model is analyzed and compared with existing…

Image and Video Processing · Electrical Eng. & Systems 2022-02-07 CH Sai Venkatesh , Caleb Meriga , M. G. V. L Geethika , T Lakshmi Gayatri , V. B. K. L Aruna

Cervical cancer, the fourth leading cause of cancer in women globally, requires early detection through Pap smear tests to identify precancerous changes and prevent disease progression. In this study, we performed a focused analysis by…

Image and Video Processing · Electrical Eng. & Systems 2025-05-22 Abdul Samad Shaik , Shashaank Mattur Aswatha , Rahul Jashvantbhai Pandya

Deep learning holds immense promise for aiding radiologists in breast cancer detection. However, achieving optimal model performance is hampered by limitations in availability and sharing of data commonly associated to patient privacy…

Computer Vision and Pattern Recognition · Computer Science 2024-07-18 Richard Osuala , Daniel M. Lang , Anneliese Riess , Georgios Kaissis , Zuzanna Szafranowska , Grzegorz Skorupko , Oliver Diaz , Julia A. Schnabel , Karim Lekadir

Microsatellite instability-high (MSI-H) is a tumor agnostic biomarker for immune checkpoint inhibitor therapy. However, MSI status is not routinely tested in prostate cancer, in part due to low prevalence and assay cost. As such, prediction…

Distributed training can facilitate the processing of large medical image datasets, and improve the accuracy and efficiency of disease diagnosis while protecting patient privacy, which is crucial for achieving efficient medical image…

Image and Video Processing · Electrical Eng. & Systems 2024-04-17 Lisang Zhou , Meng Wang , Ning Zhou

Several deep learning algorithms have been developed to predict survival of cancer patients using whole slide images (WSIs).However, identification of image phenotypes within the WSIs that are relevant to patient survival and disease…

Image and Video Processing · Electrical Eng. & Systems 2022-11-30 Xingyu Li , Jitendra Jonnagaddala , Min Cen , Hong Zhang , Xu Steven Xu

Prognostic information at diagnosis has important implications for cancer treatment and monitoring. Although cancer staging, histopathological assessment, molecular features, and clinical variables can provide useful prognostic insights,…

Differentiating tumor progression (TP) from treatment-related necrosis (TN) is critical for clinical management decisions in glioblastoma (GBM). Dynamic FDG PET (dPET), an advance from traditional static FDG PET, may prove advantageous in…

Image and Video Processing · Electrical Eng. & Systems 2023-03-01 Tonmoy Hossain , Zoraiz Qureshi , Nivetha Jayakumar , Thomas Eluvathingal Muttikkal , Sohil Patel , David Schiff , Miaomiao Zhang , Bijoy Kundu

Models need to be trained with privacy-preserving learning algorithms to prevent leakage of possibly sensitive information contained in their training data. However, canonical algorithms like differentially private stochastic gradient…

Machine Learning · Computer Science 2022-10-06 Yannis Cattan , Christopher A. Choquette-Choo , Nicolas Papernot , Abhradeep Thakurta

Deep Learning (DL) can predict biomarkers directly from digitized cancer histology in a weakly-supervised setting. Recently, the prediction of continuous biomarkers through regression-based DL has seen an increasing interest. Nonetheless,…

Image and Video Processing · Electrical Eng. & Systems 2024-03-07 Omar S. M. El Nahhas , Georg Wölflein , Marta Ligero , Tim Lenz , Marko van Treeck , Firas Khader , Daniel Truhn , Jakob Nikolas Kather

Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL)…

The study explores Artificial Intelligence (AI) powered modeling to predict the evolution of cancer tumor cells in mice under different forms of treatment. The AI models are analyzed against varying ambient and systemic parameters, e.g.…

Biological Physics · Physics 2024-08-12 Amit K Chattopadhyay , Aimee Pascaline N Unkundiye , Gillian Pearce , Steven Russell

The use of deep learning (DL) in medical image analysis has significantly improved the ability to predict lung cancer. In this study, we introduce a novel deep convolutional neural network (CNN) model, named ResNet+, which is based on the…

Image and Video Processing · Electrical Eng. & Systems 2025-07-03 Ahmad Chaddad , Jihao Peng , Yihang Wu

Motivation: Microsatellite instability (MSI) is a cancer biomarker associated with cancer prognosis and chemotherapy sensitivity. Since the discovery of MSI, polymerase chain reaction (PCR)-based testing has been considered the gold…

Genomics · Quantitative Biology 2023-04-17 Ji Detao , Liu Weier

Breast cancer is one of the most serious types of cancer that can occur in women. The automatic diagnosis of breast cancer by analyzing histological images (HIs) is important for patients and their prognosis. The classification of HIs…

Image and Video Processing · Electrical Eng. & Systems 2022-08-02 Hayder A. Khikani , Naira Elazab , Ahmed Elgarayhi , Mohammed Elmogy , Mohammed Sallah

Artificial intelligence (AI) models are increasingly used in the medical domain. However, as medical data is highly sensitive, special precautions to ensure its protection are required. The gold standard for privacy preservation is the…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Soroosh Tayebi Arasteh , Alexander Ziller , Christiane Kuhl , Marcus Makowski , Sven Nebelung , Rickmer Braren , Daniel Rueckert , Daniel Truhn , Georgios Kaissis

Graph Neural Networks (GNNs) have established themselves as the state-of-the-art models for many machine learning applications such as the analysis of social networks, protein interactions and molecules. Several among these datasets contain…

With the increased affordability and availability of whole-genome sequencing, large-scale and high-throughput gene expression is widely used to characterize diseases, including cancers. However, establishing specificity in cancer diagnosis…

Machine Learning · Statistics 2018-12-21 Xi Chen , Jin Xie , Qingcong Yuan
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