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We present a generative diffusion model specifically tailored to the discovery of surface structures. The generative model takes into account substrate registry and periodicity by including masked atoms and $z$-directional confinement.…

Computational Physics · Physics 2025-01-22 Nikolaj Rønne , Alán Aspuru-Guzik , Bjørk Hammer

With the development of computer-assisted techniques, research communities including biochemistry and deep learning have been devoted into the drug discovery field for over a decade. Various applications of deep learning have drawn great…

Machine Learning · Computer Science 2023-03-07 Wenhao Hu , Yingying Liu , Xuanyu Chen , Wenhao Chai , Hangyue Chen , Hongwei Wang , Gaoang Wang

Diffusion models have become a leading framework in generative modeling, yet their theoretical understanding -- especially for high-dimensional data concentrated on low-dimensional structures -- remains incomplete. This paper investigates…

Machine Learning · Computer Science 2026-04-29 Zixuan Zhang , Kaixuan Huang , Tuo Zhao , Mengdi Wang , Minshuo Chen

Diffusion Models (DMs) have demonstrated state-of-the-art performance in content generation without requiring adversarial training. These models are trained using a two-step process. First, a forward - diffusion - process gradually adds…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Anwaar Ulhaq , Naveed Akhtar

Diffusion Probabilistic Models (DPMs) have recently demonstrated impressive results on various generative tasks.Despite its promises, the learned representations of pre-trained DPMs, however, have not been fully understood. In this paper,…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Xingyi Yang , Xinchao Wang

Three-dimensional molecular generators based on diffusion models can now reach near-crystallographic accuracy, yet they remain fragmented across tasks. SMILES-only inputs, two-stage pretrain-finetune pipelines, and one-task-one-model…

Biomolecules · Quantitative Biology 2025-07-11 Dong Xu , Zhangfan Yang , Sisi Yuan , Jenna Xinyi Yao , Jiangqiang Li , Junkai Ji

The diffusion model has recently emerged as a potent approach in computer vision, demonstrating remarkable performances in the field of generative artificial intelligence. Capable of producing high-quality synthetic images, diffusion models…

Image and Video Processing · Electrical Eng. & Systems 2025-05-14 Abdullah , Tao Huang , Ickjai Lee , Euijoon Ahn

While many unsupervised learning models focus on one family of tasks, either generative or discriminative, we explore the possibility of a unified representation learner: a model which addresses both families of tasks simultaneously. We…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Soumik Mukhopadhyay , Matthew Gwilliam , Yosuke Yamaguchi , Vatsal Agarwal , Namitha Padmanabhan , Archana Swaminathan , Tianyi Zhou , Jun Ohya , Abhinav Shrivastava

Efficient exploration of the vast chemical space is a fundamental challenge in materials design and discovery, particularly for designing functional inorganic crystalline materials with targeted properties. Diffusion-based generative models…

Materials Science · Physics 2026-03-20 Sourav Mal , Nehad Ahmed , Junaid Jami , Subhankar Mishra , Prasenjit Sen

In this work, we introduce a novel computational framework that we developed to use numerical simulations to investigate the complexity of brain tissue at a microscopic level with a detail never realised before. Directly inspired by the…

Medical Physics · Physics 2018-06-20 Marco Palombo , Daniel C. Alexander , Hui Zhang

A recent study in turbulent flow simulation demonstrated the potential of generative diffusion models for fast 3D surrogate modeling. This approach eliminates the need for specifying initial states or performing lengthy simulations,…

Fluid Dynamics · Physics 2024-07-30 Abdullah Saydemir , Marten Lienen , Stephan Günnemann

Diffusion models have achieved remarkable progress in generative modelling, particularly in enhancing image quality to conform to human preferences. Recently, these models have also been applied to low-level computer vision for…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Ziwei Luo , Fredrik K. Gustafsson , Zheng Zhao , Jens Sjölund , Thomas B. Schön

Diffusion models arise as a powerful generative tool recently. Despite the great progress, existing diffusion models mainly focus on uni-modal control, i.e., the diffusion process is driven by only one modality of condition. To further…

Computer Vision and Pattern Recognition · Computer Science 2023-04-21 Ziqi Huang , Kelvin C. K. Chan , Yuming Jiang , Ziwei Liu

This handbook offers a unified perspective on diffusion models, encompassing diffusion probabilistic models, score-based generative models, consistency models, rectified flow, and related methods. By standardizing notations and aligning…

Machine Learning · Computer Science 2024-12-24 Zihan Ding , Chi Jin

Generating molecular structures with desired properties is a critical task with broad applications in drug discovery and materials design. We propose 3M-Diffusion, a novel multi-modal molecular graph generation method, to generate diverse,…

Machine Learning · Computer Science 2024-10-04 Huaisheng Zhu , Teng Xiao , Vasant G Honavar

Recent advances in generative modeling, namely Diffusion models, have revolutionized generative modeling, enabling high-quality image generation tailored to user needs. This paper proposes a framework for the generative design of structural…

Diffusion models, as a class of deep generative models, have recently emerged as powerful tools for robot skills by enabling stable training with reliable convergence. In this paper, we present an end-to-end framework for generating long,…

This survey paper provides a comprehensive review of the use of diffusion models in natural language processing (NLP). Diffusion models are a class of mathematical models that aim to capture the diffusion of information or signals across a…

Computation and Language · Computer Science 2023-06-16 Hao Zou , Zae Myung Kim , Dongyeop Kang

The discovery of inorganic crystal structures with targeted properties is a significant challenge in materials science. Generative models, especially state-of-the-art diffusion models, offer the promise of modeling complex data…

Diffusion models (DMs) have been investigated in various domains due to their ability to generate high-quality data, thereby attracting significant attention. However, similar to traditional deep learning systems, there also exist potential…

Cryptography and Security · Computer Science 2025-09-30 Kang Wei , Xin Yuan , Fushuo Huo , Chuan Ma , Long Yuan , Songze Li , Ming Ding , Dacheng Tao