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The de novo assembly of large, complex genomes is a significant challenge with currently available DNA sequencing technology. While many de novo assembly software packages are available, comparatively little attention has been paid to…

Genomics · Quantitative Biology 2013-07-31 Jared T. Simpson

QDNA-ID is a trust-chain framework that links physical quantum behavior to digitally verified records. The system first executes standard quantum circuits with random shot patterns across different devices to generate entropy profiles and…

Cryptography and Security · Computer Science 2025-11-25 Osamah N. Neamah

DNA is an essential molecule central to the survival and propagation of life, it was imperative to investigate possible electromagnetic properties inherent to it, such as the existence of any non-trivial interactions of this molecule with…

Biological Physics · Physics 2017-04-25 M. H. S. Bukhari , Y. Raza , S. Batool , T. Razzaki , A. Bukhari , F. Memon , M. A. Rauf , A. Rizvi , O. Bagasra

DNA computing is an unconventional approach to computing that harnesses the parallelism and information storage capabilities of DNA molecules. It has emerged as a promising field with potential applications in solving a variety of…

Emerging Technologies · Computer Science 2024-06-04 Muhammad Asad Tariq , Rafay Junaid , Muhammad Mehdy Hasnain , Danyal Farhat

High throughput genome sequencing technologies such as RNA-Seq and Microarray have the potential to transform clinical decision making and biomedical research by enabling high-throughput measurements of the genome at a granular level.…

Analyzing a functional genomics experiment, such as ATAC-, ChIP- or RNA-sequencing, requires reference data including a genome assembly and gene annotation. These resources can generally be retrieved from different organizations and in…

Genomics · Quantitative Biology 2022-09-05 Siebren Frölich , Maarten van der Sande , Tilman Schäfers , Simon J. van Heeringen

With the progressive scale-down of semiconductor's feature size, people are looking forward to More Moore and More than Moore. In order to offer a possible alternative implementation process, people are trying to figure out a feasible…

Emerging Technologies · Computer Science 2018-07-06 Chuan Zhang , Lulu Ge , Yuchen Zhuang , Ziyuan Shen , Zhiwei Zhong , Zaichen Zhang , Xiaohu You

In addition to being the core quantity in density functional theory, the charge density can be used in many tertiary analyses in materials sciences from bonding to assigning charge to specific atoms. The charge density is data-rich since it…

Simulation of non-adiabatic dynamics of a quantum system coupled to dissipative environments poses significant challenges. New sophisticated methods are regularly being developed with an eye towards moving to larger systems and more…

Quantum Physics · Physics 2023-06-07 Amartya Bose

First principle calculations of charge transfer in DNA molecules are computationally expensive given that charge carriers migrate in interaction with intra- and inter-molecular atomic motion. Screening sequences, e.g. to identify excellent…

Mesoscale and Nanoscale Physics · Physics 2020-12-04 Roman Korol , Dvira Segal

The effective visualization of genomic data is crucial for exploring and interpreting complex relationships within and across genes and genomes. Despite advances in developing dedicated bioinformatics software, common visualization tools…

Genomics · Quantitative Biology 2024-11-22 Thomas Hackl , Markus Ankenbrand , Bart van Adrichem , David Wilkins , Kristina Haslinger

Domain adaptation, a crucial sub-field of transfer learning, aims to utilize known knowledge of one data set to accomplish tasks on another data set. In this paper, we perform one of the most representative domain adaptation algorithms,…

Quantum Physics · Physics 2020-01-28 Xi He , Chufan Lyu , Min-Hsiu Hsieh , Xiaoting Wang

DNA constructs and their annotated sequence maps have been rapidly accumulating with the advancement of DNA cloning, synthesis, and assembly methods. Such a resource has the potential to be optimally utilized in an autonomous DNA building…

Quantitative Methods · Quantitative Biology 2021-12-01 Hideto Mori , Nozomu Yachie

Capturing the physical organisation and dynamics of genomic regions is one of the major open challenges in biology. The kinetoplast DNA (kDNA) is a topologically complex genome, made by thousands of DNA (mini and maxi) circles interlinked…

Soft Condensed Matter · Physics 2025-04-16 Saminathan Ramakrishnan , Auro Varat Patnaik , Guglielmo Grillo , Luca Tubiana , Davide Michieletto

Raman spectroscopy is a non-destructive and label-free chemical analysis technique, which plays a key role in the analysis and discovery cycle of various branches of science. Nonetheless, progress in Raman spectroscopic analysis is still…

Computational Pathology CPath is an interdisciplinary science that augments developments of computational approaches to analyze and model medical histopathology images. The main objective for CPath is to develop infrastructure and workflows…

The charge transfer effect is an important component in the physical description of realistic proteins. In the hybrid quantum mechanical-molecular mechanical (QM/MM) simulations, the significant charge transfer between the QM/MM boundaries…

Chemical Physics · Physics 2019-05-03 Jiajun Yang , Fang Liu , Dongju Zhang , Likai Du

When it is viewed at the scale of a base pair, DNA appears as a nonlinear lattice. Modelling its properties is a fascinating goal. The detailed experiments that can be performed on this system impose constraints on the models and can be…

Statistical Mechanics · Physics 2009-08-26 Michel Peyrard , Santiago Cuesta-Lopez , Guillaume James

Molecular carriers represent an increasingly common strategy in the field of nanopore sensing to use secondary molecules to selectively report on the presence of target analytes in solution, allowing for sensitive assays of otherwise…

Biomolecules · Quantitative Biology 2023-05-10 Zachary Roelen , Vincent Tabard-Cossa

The complex mechanisms governing charge migration in DNA oligomers reflect the rich structural and electronic properties of the molecule of life. Controlling the mechanical stability of DNA nanowires in charge transport experiments is a…

Mesoscale and Nanoscale Physics · Physics 2015-05-13 Bo Song , Marcus Elstner , Gianaurelio Cuniberti