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Biological tissues are composed of discrete compartments of biochemical media that often exhibit subtle differences in refractive index. Light propagating through these compartments partially diffracts in a forward direction with a pi/2…

Optics · Physics 2025-05-12 Gregory N. McKay , Jerome Mertz , Nicholas J. Durr

Blu-ray drive is an engineering masterpiece that integrates disc rotation, pickup head translation, and three lasers in a compact and portable format. Here we integrate a blood-coated image sensor with a modified Blu-ray drive for…

Instrumentation and Detectors · Physics 2022-10-28 Shaowei Jiang , Chengfei Guo , Tianbo Wang , Jia Liu , Pengming Song , Terrance Zhang , Ruihai Wang , Bin Feng , Guoan Zheng

Velocity map imaging (VMI) is a powerful technique that allows to infer the kinetic energy of ions or electrons that are produced from a large volume in space with good resolution. The size of the acceptance volume is determined by the…

Atomic and Molecular Clusters · Physics 2023-08-03 Yehuda Ben-Shabo , Adeliya Kurbanov , Claus Dieter Schroter , Robert Moshammer , Holger Kreckel , Yoni Toker

High-resolution Doppler-resolved spectroscopy has opened up a new window into the atmospheres of both transiting and non-transiting exoplanets. Here, we present VLT/UVES observations of a transit of WASP-121b, an 'ultra-hot' Jupiter…

Early diagnosis of ocular diseases improves the understanding of pathophysiology and helps with accurate monitoring and effective treatment. Advanced multimodal ocular imaging platforms play a crucial role in the visualization of the ocular…

Optical microscopy has a diffraction limited resolution of about 250 nm. Fluorescence methods (e.g. PALM, STORM, STED) beat this, but they are still limited to 10 s of nm, and the images are an indirect pointillist representation of only…

Score-based diffusion models have significantly advanced generative deep learning for image processing. Measurement conditioned models have also been applied to inverse problems such as CT reconstruction. However, the conventional approach,…

Medical Physics · Physics 2025-02-24 Matthew Tivnan , Dufan Wu , Quanzheng Li

Currently, diagnostic medicine uses a multitude of tools ranging from ionising radiation to histology analysis. With advances in piezoelectric crystal technology, high-frequency ultrasound imaging has developed to achieve comparatively high…

Medical Physics · Physics 2022-01-13 Akhil Kallepalli , James Halls , David B. James , Mark A. Richardson

Mid-infrared spectroscopic imaging (MIRSI) is an emerging class of label-free techniques being leveraged for digital histopathology. Modern histopathologic identification of ovarian cancer involves tissue staining followed by morphological…

Photothermal imaging is a powerful noncontact and nondestructive technique for subsurface inspection of composite materials, yet its performance is fundamentally limited by the diffusive and irreversible nature of heat transport, leading to…

Applied Physics · Physics 2026-05-06 Pengfei Zhu , Julien Lecompagnon , Philipp Daniel Hirsch , Mathias Ziegler

Thermal sensing with fine spatial resolution is important to the study of many scientific areas. While modern microscopy systems allow easy optical detection at high spatial resolution, their intrinsic functions are mainly focused on…

Optics · Physics 2018-07-04 Han Zhao , Zhaowei Chen , Ruogang Zhao , Liang Feng

Energy and charge transfer between molecules and metal surfaces underpin heterogeneous catalysis, surface-enhanced spectroscopies and plasmon-driven chemistry, yet the microscopic origins of vibrational excitation at metal interfaces remain…

Mesoscale and Nanoscale Physics · Physics 2026-01-26 Bing Gao , Jameel Damoah , Wassie M. Takele , Terefe G. Habteyes

Thermal distortion of test masses, as well as thermal drift of their vibrational mode frequencies, present a major challenge for operation of the Advanced LIGO and Advanced VIRGO interferometers, reducing optical efficiency, which limits…

Instrumentation and Methods for Astrophysics · Physics 2021-01-27 Carl D Blair , Yuri Levin , Eric Thrane

Thermal and photothermal effects play an increasing role at the nanoscale due to the general decrease of thermal conductances and to the increasing role of interfaces. Here we present a non-contact optomechanical analysis of the thermal and…

Vibrationally resolved electronic absorption spectra including the effect of vibrational pre-excitation are computed in order to interpret and predict vibronic transitions that are probed in the Vibrationally Promoted Electronic Resonance…

The mechanical properties of biological fluids can serve as early indicators of disease, offering valuable insights into complex physiological and pathological processes. However, the existing technologies can hardly support high throughput…

Optics · Physics 2025-09-18 Zhonghao Li , Zhihan Cai , Chaoyang Gong

Infrared (IR) spectroscopy, a type of vibrational spectroscopy, is widely used for molecular structure determination and provides critical structural information for chemists. However, existing approaches for recovering molecular structures…

Machine Learning · Computer Science 2026-03-09 Wenjin Wu , Aleš Leonardis , Linjiang Chen , Jianbo Jiao

Transient absorption is a very powerful observable in attosecond experiments on atoms, molecules and solids and is frequently used in experiments employing phase-locked few-cycle infrared and XUV laser pulses derived from high harmonic…

Atomic Physics · Physics 2020-08-26 Lorenz Drescher , Marc J. J. Vrakking , Jochen Mikosch

Polarimetric imaging provides valuable insights into the polarization state of light interacting with a sample. It can infer crucial birefringence properties of bio-specimens without using any labels, thereby facilitating the diagnosis of…

We demonstrate a cryogenic scanned probe microscope (SPM) that has been modified to be controlled with a haptic device, such that the operator can `feel' the surface of a sample under investigation. This system allows for direct tactile…

Instrumentation and Detectors · Physics 2022-08-29 Maxwell Freeman , Rhett Applestone , Wyatt Behn , Victor Brar