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Radiation therapy treatment planning is an iterative, expertise-dependent process, and the growing burden of cancer cases has made reliance on manual planning increasingly unsustainable, underscoring the need for automation. In this study,…

Medical Physics · Physics 2025-10-15 Dongrong Yang , Xin Wu , Yibo Xie , Xinyi Li , Qiuwen Wu , Jackie Wu , Yang Sheng

In contemporary radiotherapy planning (RTP), a key module leaf sequencing is predominantly addressed by optimization-based approaches. In this paper, we propose a novel deep reinforcement learning (DRL) model termed as Reinforced Leaf…

Machine Learning · Computer Science 2024-06-05 Riqiang Gao , Florin C. Ghesu , Simon Arberet , Shahab Basiri , Esa Kuusela , Martin Kraus , Dorin Comaniciu , Ali Kamen

Deep learning-based automated contouring and treatment planning has been proven to improve the efficiency and accuracy of radiotherapy. However, conventional radiotherapy treatment planning process has the automated contouring and treatment…

Medical Physics · Physics 2024-12-02 Sangwook Kim , Aly Khalifa , Thomas G. Purdie , Chris McIntosh

Objective: Machine learning (ML) based radiation treatment (RT) planning addresses the iterative and time-consuming nature of conventional inverse planning. Given the rising importance of Magnetic resonance (MR) only treatment planning…

Medical Physics · Physics 2022-06-13 Aly Khalifa , Jeff Winter , Inmaculada Navarro , Chris McIntosh , Thomas G. Purdie

Fine-tuning foundation models has emerged as a powerful approach for generating objects with specific desired properties. Reinforcement learning (RL) provides an effective framework for this purpose, enabling models to generate outputs that…

Machine Learning · Computer Science 2025-11-04 Pouya M. Ghari , Simone Sciabola , Ye Wang

Typical multi-task learning (MTL) methods rely on architectural adjustments and a large trainable parameter set to jointly optimize over several tasks. However, when the number of tasks increases so do the complexity of the architectural…

Computer Vision and Pattern Recognition · Computer Science 2019-03-29 Gjorgji Strezoski , Nanne van Noord , Marcel Worring

Microbeam radiation therapy (MRT) utilizes coplanar synchrotron radiation beamlets and is a proposed treatment approach for several tumour diagnoses that currently have poor clinical treatment outcomes, such as gliosarcomas. Prescription…

Model-based reinforcement learning (RL) has proven to be a data efficient approach for learning control tasks but is difficult to utilize in domains with complex observations such as images. In this paper, we present a method for learning…

Machine Learning · Computer Science 2019-06-25 Marvin Zhang , Sharad Vikram , Laura Smith , Pieter Abbeel , Matthew J. Johnson , Sergey Levine

Multi-task learning (MTL) is a machine learning technique aiming to improve model performance by leveraging information across many tasks. It has been used extensively on various data modalities, including electronic health record (EHR)…

Machine Learning · Computer Science 2020-07-21 Matthew B. A. McDermott , Bret Nestor , Evan Kim , Wancong Zhang , Anna Goldenberg , Peter Szolovits , Marzyeh Ghassemi

The training of deep learning models typically requires extensive data, which are not readily available as large well-curated medical-image datasets for development of artificial intelligence (AI) models applied in Radiology. Recognizing…

Medical image registration and segmentation are two of the most frequent tasks in medical image analysis. As these tasks are complementary and correlated, it would be beneficial to apply them simultaneously in a joint manner. In this paper,…

Image and Video Processing · Electrical Eng. & Systems 2021-05-06 Mohamed S. Elmahdy , Laurens Beljaards , Sahar Yousefi , Hessam Sokooti , Fons Verbeek , U. A. van der Heide , Marius Staring

Large language models (LLMs) have emerged as transformative tools in medicine, with strong capabilities in language understanding, reasoning, and structured information extraction. Radiation oncology is particularly well suited for LLM…

Recent advances in medical large language models have explored Test-Time Reinforcement Learning (TTRL) to enhance reasoning. However, standard TTRL often relies on majority voting (MV) as a heuristic supervision signal, which can be…

Machine Learning · Computer Science 2026-03-11 Kailong Fan , Anqi Pu , Yichen Wu , Wanhua Li , Yicong Li , Hanspeter Pfister , Huafeng Liu , Xiang Li , Quanzheng Li , Ning Guo

Radiotherapy (RT) is a critical cancer treatment, with volumetric modulated arc therapy (VMAT) being a commonly used technique that enhances dose conformity by dynamically adjusting multileaf collimator (MLC) positions and monitor units…

Medical Physics · Physics 2025-06-26 Stefanos Achlatis , Efstratios Gavves , Jan-Jakob Sonke

Driven by the key challenges of cell therapy manufacturing, including high complexity, high uncertainty, and very limited process observations, we propose a hybrid model-based reinforcement learning (RL) to efficiently guide process…

Systems and Control · Electrical Eng. & Systems 2022-01-27 Hua Zheng , Wei Xie , Keqi Wang , Zheng Li

Several Radio Resource Management (RRM) use cases can be framed as sequential decision planning problems, where an agent (the base station, typically) makes decisions that influence the network utility and state. While Reinforcement…

Networking and Internet Architecture · Computer Science 2024-05-31 Lorenzo Maggi , Matthew Andrews , Ryo Koblitz

Reinforcement Learning (RL) is a method for learning decision-making tasks that could enable robots to learn and adapt to their situation on-line. For an RL algorithm to be practical for robotic control tasks, it must learn in very few…

Artificial Intelligence · Computer Science 2015-03-19 Todd Hester , Michael Quinlan , Peter Stone

The increasing adoption of natural language processing (NLP) models across industries has led to practitioners' need for machine learning systems to handle these models efficiently, from training to serving them in production. However,…

Computation and Language · Computer Science 2023-08-17 Lovre Torbarina , Tin Ferkovic , Lukasz Roguski , Velimir Mihelcic , Bruno Sarlija , Zeljko Kraljevic

Sequential decision making, commonly formalized as Markov Decision Process (MDP) optimization, is a important challenge in artificial intelligence. Two key approaches to this problem are reinforcement learning (RL) and planning. This paper…

Machine Learning · Computer Science 2022-04-01 Thomas M. Moerland , Joost Broekens , Aske Plaat , Catholijn M. Jonker

The functionality of Large Language Model (LLM) agents is primarily determined by two capabilities: action planning and answer summarization. The former, action planning, is the core capability that dictates an agent's performance. However,…

Machine Learning · Computer Science 2025-08-28 Zhiwei Li , Yong Hu , Wenqing Wang
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