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Survival analysis is a critical tool for modeling time-to-event data. Recent deep learning-based models have reduced various modeling assumptions including proportional hazard and linearity. However, a persistent challenge remains in…

Machine Learning · Computer Science 2025-12-30 Maxmillan Ries , Sohan Seth

Survival analysis plays a crucial role in many healthcare decisions, where the risk prediction for the events of interest can support an informative outlook for a patient's medical journey. Given the existence of data censoring, an…

Machine Learning · Computer Science 2023-09-29 Mohsen Nayebi Kerdabadi , Arya Hadizadeh Moghaddam , Bin Liu , Mei Liu , Zijun Yao

Additive models offer accurate and interpretable predictions for tabular data, a critical tool for statistical modeling. Recent advances in Neural Additive Models (NAMs) allow these models to handle complex machine learning tasks, including…

Machine Learning · Computer Science 2025-03-12 Mike Van Ness , Madeleine Udell

Survival analysis or time-to-event analysis aims to model and predict the time it takes for an event of interest to happen in a population or an individual. In the medical context this event might be the time of dying, metastasis,…

Machine Learning · Computer Science 2022-02-09 Shadi Rahimian , Raouf Kerkouche , Ina Kurth , Mario Fritz

Most existing time-to-event methods focus on either single-event or competing-risks settings, leaving multi-event scenarios relatively underexplored. In many healthcare applications, for example, a patient may experience multiple clinical…

Machine Learning · Computer Science 2025-11-20 Christian Marius Lillelund , Ali Hossein Gharari Foomani , Weijie Sun , Shi-ang Qi , Russell Greiner

Multi-center survival prediction can improve robustness and generalizability, yet privacy regulations and institutional governance often prevent pooling patient-level clinical and genomic data across institutions. In practice, deployment is…

Interval-censored data analysis is important in biomedical statistics for any type of time-to-event response where the time of response is not known exactly, but rather only known to occur between two assessment times. Many clinical trials…

Methodology · Statistics 2019-06-12 Weichi Yao , Halina Frydman , Jeffrey S. Simonoff

Survival analysis serves as a fundamental component in numerous healthcare applications, where the determination of the time to specific events (such as the onset of a certain disease or death) for patients is crucial for clinical…

Artificial Intelligence · Computer Science 2025-10-23 Siqi Li , Yuqing Shang , Ziwen Wang , Qiming Wu , Chuan Hong , Yilin Ning , Di Miao , Marcus Eng Hock Ong , Bibhas Chakraborty , Nan Liu

Statistical models serve as the cornerstone for hypothesis testing in empirical studies. This paper introduces a new cross-platform Python-based package designed to utilise different likelihood prescriptions via a flexible plug-in system.…

High Energy Physics - Phenomenology · Physics 2024-01-29 Jack Y. Araz

Survival Analysis (SA) constitutes the default method for time-to-event modeling due to its ability to estimate event probabilities of sparsely occurring events over time. In this work, we show how to improve the training and inference of…

Machine Learning · Computer Science 2023-12-12 Chris Solomou

Causal inference across multiple data sources offers a promising avenue to enhance the generalizability and replicability of scientific findings. However, data integration methods for time-to-event outcomes, common in biomedical research,…

Methodology · Statistics 2025-05-16 Yi Liu , Alexander W. Levis , Ke Zhu , Shu Yang , Peter B. Gilbert , Larry Han

The abundance of modern health data provides many opportunities for the use of machine learning techniques to build better statistical models to improve clinical decision making. Predicting time-to-event distributions, also known as…

Machine Learning · Statistics 2020-12-15 Zidi Xiu , Chenyang Tao , Benjamin A. Goldstein , Ricardo Henao

Despite the explosion of interest in healthcare AI research, the reproducibility and benchmarking of those research works are often limited due to the lack of standard benchmark datasets and diverse evaluation metrics. To address this…

Machine Learning · Computer Science 2021-01-13 Yue Zhao , Zhi Qiao , Cao Xiao , Lucas Glass , Jimeng Sun

Multiplexed imaging data are revolutionizing our understanding of the composition and organization of tissues and tumors. A critical aspect of such tissue profiling is quantifying the spatial relationship relationships among cells at…

Quantitative Methods · Quantitative Biology 2024-05-06 Ajit J. Nirmal , Peter K. Sorger

In epidemiological studies of time-to-event data, a quantity of interest to the clinician and the patient is the risk of an event given a covariate profile. However, methods relying on time matching or risk-set sampling (including Cox…

Methodology · Statistics 2020-09-23 Sahir Rai Bhatnagar , Maxime Turgeon , Jesse Islam , James A. Hanley , Olli Saarela

A class of multivariate mixed survival models for continuous and discrete time with a complex covariance structure is introduced in a context of quantitative genetic applications. The methods introduced can be used in many applications in…

Applications · Statistics 2014-05-06 Rafael Pimentel Maia , Per Madsen , Rodrigo Labouriau

In this work, we discuss what we refer to as reduction techniques for survival analysis, that is, techniques that "reduce" a survival task to a more common regression or classification task, without ignoring the specifics of survival data.…

Machine learning applications for longitudinal electronic health records often forecast the risk of events at fixed time points, whereas survival analysis achieves dynamic risk prediction by estimating time-to-event distributions. Here, we…

Machine Learning · Computer Science 2024-11-26 Munib Mesinovic , Peter Watkinson , Tingting Zhu

Analyzing multi-source data, which are multiple views of data on the same subjects, has become increasingly common in molecular biomedical research. Recent methods have sought to uncover underlying structure and relationships within and/or…

Machine Learning · Statistics 2021-03-01 Elise F. Palzer , Christine Wendt , Russell Bowler , Craig P. Hersh , Sandra E. Safo , Eric F. Lock

As large language models (LLMs) become ubiquitous, parameter-efficient fine-tuning methods and safety-first defenses have proliferated rapidly. However, the number of approaches and their recent increase have resulted in diverse…

Machine Learning · Computer Science 2025-06-03 Saad Hossain , Samanvay Vajpayee , Sirisha Rambhatla
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