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Identifying variables responsible for changes to a biological system enables applications in drug target discovery and cell engineering. Given a pair of observational and interventional datasets, the goal is to isolate the subset of…

Machine Learning · Computer Science 2025-06-02 Menghua Wu , Umesh Padia , Sean H. Murphy , Regina Barzilay , Tommi Jaakkola

Most information dynamics and statistical causal analysis frameworks rely on the common intuition that causal interactions are intrinsically pairwise -- every 'cause' variable has an associated 'effect' variable, so that a 'causal arrow'…

Neurons and Cognition · Quantitative Biology 2019-09-06 Pedro A. M. Mediano , Fernando Rosas , Robin L. Carhart-Harris , Anil K. Seth , Adam B. Barrett

Urban metro systems move vast numbers of passengers with a high level of efficiency in resource use, but frequently experience disruptions that result in delays, crowding, and deterioration in passenger satisfaction and patronage. To…

Applications · Statistics 2025-08-29 Nan Zhang , Daniel Hörcher , Prateek Bansal , Daniel J. Graham

Time series analysis has proven to be a powerful method to characterize several phenomena in biology, neuroscience and economics, and to understand some of their underlying dynamical features. Despite a plethora of methods have been…

Physics and Society · Physics 2023-03-01 Andrea Santoro , Federico Battiston , Giovanni Petri , Enrico Amico

Recent advances in signal processing and information theory are boosting the development of new approaches for the data-driven modelling of complex network systems. In the fields of Network Physiology and Network Neuroscience where the…

Methodology · Statistics 2024-01-23 Laura Sparacino , Yuri Antonacci , Gorana Mijatovic , Luca Faes

Graphical models are widely used to study biological networks. Interventions on network nodes are an important feature of many experimental designs for the study of biological networks. In this paper we put forward a causal variant of…

Methodology · Statistics 2015-06-17 Simon E. F. Spencer , Steven M. Hill , Sach Mukherjee

Understanding the interaction patterns among simultaneous recordings of spike trains from multiple neuronal units is a key topic in neuroscience. However, an optimal approach of assessing these interactions has not been established, as…

Neurons and Cognition · Quantitative Biology 2020-12-17 Gorana Mijatovic , Yuri Antonacci , Tatjana Loncar-Turukalo , Ludovico Minati , Luca Faes

In modeling multivariate time series for either forecast or policy analysis, it would be beneficial to have figured out the cause-effect relations within the data. Regression analysis, however, is generally for correlation relation, and…

Machine Learning · Statistics 2021-11-23 Xingwei Hu

Inference of causality in time series has been principally based on the prediction paradigm. Nonetheless, the predictive causality approach may overlook the simultaneous and reciprocal nature of causal interactions observed in real world…

Data Analysis, Statistics and Probability · Physics 2018-10-24 Albert C. Yang , Norden E. Huang , Chung-Kang Peng

Network inference, the task of reconstructing interactions in a complex system from experimental observables, is a central yet extremely challenging problem in systems biology. While much progress has been made in the last two decades,…

Quantitative Methods · Quantitative Biology 2024-09-12 Stephen Y Zhang

Multivariate Bernoulli autoregressive (BAR) processes model time series of events in which the likelihood of current events is determined by the times and locations of past events. These processes can be used to model nonlinear dynamical…

Machine Learning · Statistics 2018-11-08 Benjamin Mark , Garvesh Raskutti , Rebecca Willett

The information implicitly represented in the state of physical systems allows one to analyze them with analytical techniques from statistical mechanics and information theory. In the case of complex networks such techniques are inspired by…

Physics and Society · Physics 2023-08-09 Wout Merbis , Manlio de Domenico

Emergence, where complex behaviors develop from the interactions of simpler components within a network, plays a crucial role in enhancing neural network capabilities. We introduce a quantitative framework to measure emergence during the…

Machine Learning · Computer Science 2024-09-04 Faisal AlShinaifi , Zeyad Almoaigel , Johnny Jingze Li , Abdulla Kuleib , Gabriel A. Silva

What is the most crucial characteristic of a system with life activity? Currently, many theories have attempted to explain the most essential difference between living systems and general systems, such as the self-organization theory and…

Molecular Networks · Quantitative Biology 2025-01-29 Mingzhe Yang , Linli Pan , Jiang Zhang

Recent causal inference literature has introduced causal effect decompositions to quantify sources of observed inequalities or disparities in outcomes, but these approaches are typically limited to pairwise comparisons. In healthcare…

Methodology · Statistics 2026-04-27 Lin Yu , Zhihui Liu , Kathy Han , Olli Saarela

Vector Auto-Regressive (VAR) models capture lead-lag temporal dynamics of multivariate time series data. They have been widely used in macroeconomics, financial econometrics, neuroscience and functional genomics. In many applications, the…

Methodology · Statistics 2021-10-15 Peiliang Bai , Yue Bai , Abolfazl Safikhani , George Michailidis

The emergence of nontrivial collective behavior in networks of coupled chaotic maps is investigated by means of a nonlinear mutual prediction method. The resulting prediction error is used to measure the amount of information that a local…

Chaotic Dynamics · Physics 2009-11-07 L. Cisneros , J. Jimenez , M. G. Cosenza , A. Parravano

It is well recognised that animal and plant pathogens form complex ecological communities of interacting organisms within their hosts. Although community ecology approaches have been applied to determine pathogen interactions at the…

Obtaining meaningful quantitative descriptions of the statistical dependence within multivariate systems is a difficult open problem. Recently, the Partial Information Decomposition (PID) was proposed to decompose mutual information (MI)…

Information Theory · Computer Science 2017-02-21 Robin A. A. Ince

Complex systems such as ecological communities and neuron networks are essential parts of our everyday lives. These systems are composed of units which interact through intricate networks. The ability to predict sudden changes in the…

Adaptation and Self-Organizing Systems · Physics 2021-07-07 Deniz Eroglu , Matteo Tanzi , Sebastian van Strien , Tiago Pereira