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This paper explores the challenges in evaluating machine learning (ML) models for continuous health monitoring using wearable devices beyond conventional metrics. We state the complexities posed by real-world variability, disease dynamics,…

Machine Learning · Computer Science 2023-12-06 Cheng Ding , Zhicheng Guo , Cynthia Rudin , Ran Xiao , Fadi B Nahab , Xiao Hu

Large Language Models (LLMs) have shown promise in clinical applications through prompt engineering, allowing flexible clinical predictions. However, they struggle to produce reliable prediction probabilities, which are crucial for…

Artificial Intelligence · Computer Science 2024-12-05 Bowen Gu , Rishi J. Desai , Kueiyu Joshua Lin , Jie Yang

As machine learning (ML) systems take a more prominent and central role in contributing to life-impacting decisions, ensuring their trustworthiness and accountability is of utmost importance. Explanations sit at the core of these desirable…

Machine Learning · Computer Science 2021-06-16 Sahil Verma , Aditya Lahiri , John P. Dickerson , Su-In Lee

Recent efforts in Machine Learning (ML) interpretability have focused on creating methods for explaining black-box ML models. However, these methods rely on the assumption that simple approximations, such as linear models or decision-trees,…

Machine Learning · Computer Science 2019-06-13 Owen Lahav , Nicholas Mastronarde , Mihaela van der Schaar

Ensuring trustworthiness in machine learning (ML) systems is crucial as they become increasingly embedded in high-stakes domains. This paper advocates for integrating causal methods into machine learning to navigate the trade-offs among key…

Machine Learning · Computer Science 2026-03-16 Ruta Binkyte , Ivaxi Sheth , Zhijing Jin , Mohammad Havaei , Bernhard Schölkopf , Mario Fritz

Despite the widespread adoption of large language models (LLMs) for recommendation, we demonstrate that LLMs often exhibit uncertainty in their recommendations. To ensure the trustworthy use of LLMs in generating recommendations, we…

Information Retrieval · Computer Science 2025-02-13 Wonbin Kweon , Sanghwan Jang , SeongKu Kang , Hwanjo Yu

A central question in machine learning is how reliable the predictions of a trained model are. Reliability includes the identification of instances for which a model is likely not to be trusted based on an analysis of the learning system…

Quantum Physics · Physics 2026-01-21 Marie Kempkes , Jakob Spiegelberg , Evert van Nieuwenburg , Vedran Dunjko

Causal machine learning (Causal ML) aims to answer "what if" questions using machine learning algorithms, making it a promising tool for high-stakes decision-making. Yet, empirical evaluation practices in Causal ML remain limited. Existing…

While predictive accuracy is often prioritized in machine learning (ML) models, interpretability remains essential in scientific and high-stakes domains. However, diverse interpretability algorithms frequently yield conflicting…

Machine Learning · Computer Science 2026-04-29 Antonio Jesús Banegas-Luna , Horacio Pérez-Sánchez , Carlos Martínez-Cortés

The introduction of computational techniques to analyze chemical data has given rise to the analytical study of biological systems, known as "bioinformatics". One facet of bioinformatics is using machine learning (ML) technology to detect…

Quantitative Methods · Quantitative Biology 2022-08-23 Tanish Jain , Praveen Kumar Pandian Shanmuganathan

Machine learning (ML) methods are proliferating in scientific research. However, the adoption of these methods has been accompanied by failures of validity, reproducibility, and generalizability. These failures can hinder scientific…

Automated Machine Learning-based systems' integration into a wide range of tasks has expanded as a result of their performance and speed. Although there are numerous advantages to employing ML-based systems, if they are not interpretable,…

Machine Learning · Computer Science 2022-12-08 Ioannis Mollas , Nick Bassiliades , Grigorios Tsoumakas

Machine Learning (ML) research has increased substantially in recent years, due to the success of predictive modeling across diverse application domains. However, well-known barriers exist when attempting to deploy ML models in high-stakes,…

Machine Learning · Computer Science 2024-09-19 Nathan Wolfrath , Joel Wolfrath , Hengrui Hu , Anjishnu Banerjee , Anai N. Kothari

As machine learning systems are increasingly used in high-stakes domains, there is a growing emphasis placed on making them interpretable to improve trust in these systems. In response, a range of interpretable machine learning (IML)…

Machine Learning · Statistics 2025-05-22 Luqin Gan , Tarek M. Zikry , Genevera I. Allen

As large language models (LLMs) continue to demonstrate remarkable abilities across various domains, computer scientists are developing methods to understand their cognitive processes, particularly concerning how (and if) LLMs internally…

Artificial Intelligence · Computer Science 2025-03-17 Daniel A. Herrmann , Benjamin A. Levinstein

Machine Learning (ML) has become an integral aspect of many real-world applications. As a result, the need for responsible machine learning has emerged, focusing on aligning ML models to ethical and social values, while enhancing their…

Machine Learning · Computer Science 2024-02-06 Raha Moraffah , Paras Sheth , Saketh Vishnubhatla , Huan Liu

Machine Learning (ML) is increasingly used to implement advanced applications with non-deterministic behavior, which operate on the cloud-edge continuum. The pervasive adoption of ML is urgently calling for assurance solutions assessing…

Machine Learning · Computer Science 2023-10-24 Marco Anisetti , Claudio A. Ardagna , Nicola Bena , Ernesto Damiani

In machine learning (ML), it is in general challenging to provide a detailed explanation on how a trained model arrives at its prediction. Thus, usually we are left with a black-box, which from a scientific standpoint is not satisfactory.…

Materials Science · Physics 2021-04-22 Luca M. Ghiringhelli

Background: The rapid advancement of Machine Learning (ML) represents novel opportunities to enhance public health research, surveillance, and decision-making. However, there is a lack of comprehensive understanding of algorithmic bias,…

Machine Learning · Computer Science 2024-09-04 Shaina Raza , Arash Shaban-Nejad , Elham Dolatabadi , Hiroshi Mamiya

Trustworthy machine learning is driving a large number of ML community works in order to improve ML acceptance and adoption. The main aspect of trustworthy machine learning are the followings: fairness, uncertainty, robustness,…

Machine Learning · Computer Science 2022-07-08 Gregory Scafarto , Nicolas Posocco , Antoine Bonnefoy