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Protein language models such as ESM-2 learn rich residue representations that achieve strong performance on protein function prediction, but their features remain difficult to interpret as structural $\&$ evolutionary signals are encoded in…

Machine Learning · Computer Science 2026-05-13 Siddhant Dutta , Edward Tan Beng Wai , Soumick Sarker , Pasan Gunawardane , Jagath C. Rajapakse

Large language models (LLMs) are renowned for their extensive linguistic knowledge and strong generalization capabilities, but their high computational demands make them unsuitable for resource-constrained environments. In contrast, small…

Computation and Language · Computer Science 2025-06-10 Kyeonghyun Kim , Jinhee Jang , Juhwan Choi , Yoonji Lee , Kyohoon Jin , YoungBin Kim

Pre-trained large language models (PLMs) underlie most new developments in natural language processing. They have shifted the field from application-specific model pipelines to a single model that is adapted to a wide range of tasks.…

Computation and Language · Computer Science 2023-06-30 Joshua Maynez , Priyanka Agrawal , Sebastian Gehrmann

Predictive analysis is a cornerstone of modern decision-making, with applications in various domains. Large Language Models (LLMs) have emerged as powerful tools in enabling nuanced, knowledge-intensive conversations, thus aiding in complex…

Computation and Language · Computer Science 2025-05-26 Qin Chen , Yuanyi Ren , Xiaojun Ma , Yuyang Shi

This study investigates the current landscape and future directions of protein foundation model research. While recent advancements have transformed protein science and engineering, the field lacks a comprehensive benchmark for fair…

Biomolecules · Quantitative Biology 2025-06-19 Zhangyang Gao , Hao Wang , Cheng Tan , Chenrui Xu , Mengdi Liu , Bozhen Hu , Linlin Chao , Xiaoming Zhang , Stan Z. Li

The rapid development of Large Language Models (LLMs) has catalyzed significant advancements in video understanding technologies. This survey provides a comprehensive analysis of benchmarks and evaluation methodologies specifically designed…

Computer Vision and Pattern Recognition · Computer Science 2025-05-08 Yogesh Kumar

Prompt tuning, which involves training a small set of parameters, effectively enhances the pre-trained Vision-Language Models (VLMs) to downstream tasks. However, they often come at the cost of flexibility and adaptability when the tuned…

Computer Vision and Pattern Recognition · Computer Science 2024-07-08 Mushui Liu , Bozheng Li , Yunlong Yu

Large Language Models (LLMs) have the potential to accelerate small molecule drug design due to their ability to reason about information from diverse sources and formats. However, their practical utility remains unclear due to the lack of…

[Context and motivation] Large language models (LLMs) show notable results in natural language processing (NLP) tasks for requirements engineering (RE). However, their use is compromised by high computational cost, data sharing risks, and…

Software Engineering · Computer Science 2025-10-27 Mohammad Amin Zadenoori , Vincenzo De Martino , Jacek Dabrowski , Xavier Franch , Alessio Ferrari

Language models have gained significant interest due to their general-purpose capabilities, which appear to emerge as models are scaled to increasingly larger parameter sizes. However, these large models impose stringent requirements on…

Machine Learning · Computer Science 2024-12-23 Savitha Viswanadh Kandala , Pramuka Medaranga , Ambuj Varshney

Large Language Models (LLMs) have recently demonstrated impressive capabilities across various real-world applications. However, due to the current text-in-text-out paradigm, it remains challenging for LLMs to handle dynamic and complex…

Artificial Intelligence · Computer Science 2024-10-25 Timothy Wei , Annabelle Miin , Anastasia Miin

It is crucial for large language models (LLMs) to follow instructions that involve multiple constraints. However, it is an unexplored area to enhance LLMs' ability to follow soft constraints. To bridge the gap, we initially design a…

Computation and Language · Computer Science 2025-06-03 Qingyu Ren , Jie Zeng , Qianyu He , Jiaqing Liang , Yanghua Xiao , Weikang Zhou , Zeye Sun , Fei Yu

We introduce Large Language Model-Assisted Preference Prediction (LAPP), a novel framework for robot learning that enables efficient, customizable, and expressive behavior acquisition with minimum human effort. Unlike prior approaches that…

Robotics · Computer Science 2025-04-23 Pingcheng Jian , Xiao Wei , Yanbaihui Liu , Samuel A. Moore , Michael M. Zavlanos , Boyuan Chen

The rapid spread of multilingual misinformation requires robust automated fact verification systems capable of handling fine-grained veracity assessments across diverse languages. While large language models have shown remarkable…

Computation and Language · Computer Science 2025-07-29 Hanna Shcharbakova , Tatiana Anikina , Natalia Skachkova , Josef van Genabith

In current benchmarks for evaluating large language models (LLMs), there are issues such as evaluation content restriction, untimely updates, and lack of optimization guidance. In this paper, we propose a new paradigm for the measurement of…

Computation and Language · Computer Science 2024-07-11 Jin Liu , Qingquan Li , Wenlong Du

Large language models (LLMs) exhibit substantial performance disparities across languages, particularly between high- and low-resource settings. We propose a framework for improving performance in underrepresented languages while preserving…

Computation and Language · Computer Science 2026-02-05 Daniil Gurgurov , Tanja Baeumel , Josef van Genabith , Simon Ostermann

Recently, Large Language Models (LLMs) have showcased their potential in various natural language processing tasks, including code generation. However, while significant progress has been made in adapting LLMs to generate code for several…

Machine Learning · Computer Science 2024-07-29 Erica Coppolillo , Francesco Calimeri , Giuseppe Manco , Simona Perri , Francesco Ricca

Large Language Models (LLMs) are difficult to fully fine-tune (e.g., with instructions or human feedback) due to their sheer number of parameters. A family of parameter-efficient sparse fine-tuning methods have proven promising in terms of…

Computation and Language · Computer Science 2024-02-05 Alan Ansell , Ivan Vulić , Hannah Sterz , Anna Korhonen , Edoardo M. Ponti

As machine learning becomes increasingly central to molecular design, it is vital to ensure the reliability of learnable protein-ligand scoring functions on novel protein targets. While many scoring functions perform well on standard…

Machine Learning · Computer Science 2025-12-08 Jakub Kopko , David Graber , Saltuk Mustafa Eyrilmez , Stanislav Mazurenko , David Bednar , Jiri Sedlar , Josef Sivic

Large language models (LLMs) achieve strong performance across diverse tasks, largely driven by high-quality web data used in pre-training. However, recent studies indicate this data source is rapidly depleting. Synthetic data emerges as a…

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