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Hypergraph neural networks can model multi-way connections among nodes of the graphs, which are common in real-world applications such as genetic medicine. In particular, genetic pathways or gene sets encode molecular functions driven by…

Machine Learning · Computer Science 2022-10-17 Yuan Luo

Hypergraphs tackle the limitations of traditional graphs by introducing {\em hyperedges}. While graph edges connect only two nodes, hyperedges connect an arbitrary number of nodes along their edges. Also, the underlying message-passing…

Machine Learning · Computer Science 2024-09-17 Mehrad Soltani , Luis Rueda

Graph convolutional networks (GCNs) have emerged as a powerful alternative to multiple instance learning with convolutional neural networks in digital pathology, offering superior handling of structural information across various spatial…

Image and Video Processing · Electrical Eng. & Systems 2024-03-25 Victor Ibañez , Przemyslaw Szostak , Quincy Wong , Konstanty Korski , Samaneh Abbasi-Sureshjani , Alvaro Gomariz

Many researches demonstrated that the DNA methylation, which occurs in the context of a CpG, has strong correlation with diseases, including cancer. There is a strong interest in analyzing the DNA methylation data to find how to distinguish…

Genomics · Quantitative Biology 2020-01-29 Hong Yu , Zhanyu Ma

Metastasis is a leading cause of cancer-related mortality and remains challenging to detect during early stages. Accurate identification of cancers likely to metastasize can improve treatment strategies and patient outcomes. This study…

Genomics · Quantitative Biology 2024-12-03 Benjamin Osafo Agyare , Alec Chu , Blessing Oloyede

Graph-based semi-supervised node classification has been shown to become a state-of-the-art approach in many applications with high research value and significance. Most existing methods are only based on the original intrinsic or…

Machine Learning · Computer Science 2023-06-08 Jianpeng Liao , Jun Yan , Qian Tao

Purpose: Bone metastasis have a major impact on the quality of life of patients and they are diverse in terms of size and location, making their segmentation complex. Manual segmentation is time-consuming, and expert segmentations are…

Image and Video Processing · Electrical Eng. & Systems 2024-09-18 Emile Saillard , Aurélie Levillain , David Mitton , Jean-Baptiste Pialat , Cyrille Confavreux , Hélène Follet , Thomas Grenier

Brain metastases occur frequently in patients with metastatic cancer. Early and accurate detection of brain metastases is very essential for treatment planning and prognosis in radiation therapy. To improve brain metastasis detection…

Detecting and segmenting brain metastases is a tedious and time-consuming task for many radiologists, particularly with the growing use of multi-sequence 3D imaging. This study demonstrates automated detection and segmentation of brain…

Image and Video Processing · Electrical Eng. & Systems 2019-12-30 Endre Grøvik , Darvin Yi , Michael Iv , Elisabeth Tong , Daniel L. Rubin , Greg Zaharchuk

Occlusion is a common problem with biometric recognition in the wild. The generalization ability of CNNs greatly decreases due to the adverse effects of various occlusions. To this end, we propose a novel unified framework integrating the…

Computer Vision and Pattern Recognition · Computer Science 2023-07-28 Min Ren , Yunlong Wang , Yuhao Zhu , Kunbo Zhang , Zhenan Sun

Learning good representation of giga-pixel level whole slide pathology images (WSI) for downstream tasks is critical. Previous studies employ multiple instance learning (MIL) to represent WSIs as bags of sampled patches because, for most…

Computer Vision and Pattern Recognition · Computer Science 2022-12-01 Chunyuan Li , Xinliang Zhu , Jiawen Yao , Junzhou Huang

Multimodal pathology-genomic analysis has become increasingly prominent in cancer survival prediction. However, existing studies mainly utilize multi-instance learning to aggregate patch-level features, neglecting the information loss of…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Mingcheng Qu , Guang Yang , Donglin Di , Tonghua Su , Yue Gao , Yang Song , Lei Fan

The identification of cancer genes is a critical yet challenging problem in cancer genomics research. Existing computational methods, including deep graph neural networks, fail to exploit the multilayered gene-gene interactions or provide…

Machine Learning · Computer Science 2023-05-04 Michail Chatzianastasis , Michalis Vazirgiannis , Zijun Zhang

Hyperbolic geometry has emerged as a powerful tool for modeling complex, structured data, particularly where hierarchical or tree-like relationships are present. By enabling embeddings with lower distortion, hyperbolic neural networks offer…

Machine Learning · Computer Science 2025-06-18 Pol Arévalo , Alexis Molina , Álvaro Ciudad

Breast cancer is one of the most common cancers in women worldwide, and early detection can significantly reduce the mortality rate of breast cancer. It is crucial to take multi-scale information of tissue structure into account in the…

Computer Vision and Pattern Recognition · Computer Science 2021-01-01 Mo Zhang , Quanzheng Li

With the advances of data-driven machine learning research, a wide variety of prediction problems have been tackled. It has become critical to explore how machine learning and specifically deep learning methods can be exploited to analyse…

Machine Learning · Computer Science 2021-11-09 David Ahmedt-Aristizabal , Mohammad Ali Armin , Simon Denman , Clinton Fookes , Lars Petersson

Heterogeneous graph neural networks (HGNNs) were proposed for representation learning on structural data with multiple types of nodes and edges. To deal with the performance degradation issue when HGNNs become deep, researchers combine…

Machine Learning · Computer Science 2023-11-27 Xinyu Fu , Irwin King

The density of mitotic figures within tumor tissue is known to be highly correlated with tumor proliferation and thus is an important marker in tumor grading. Recognition of mitotic figures by pathologists is known to be subject to a strong…

Graph representation learning in Euclidean space, despite its widespread adoption and proven utility in many domains, often struggles to effectively capture the inherent hierarchical and complex relational structures prevalent in real-world…

Machine Learning · Computer Science 2025-08-26 Menglin Yang , Min Zhou , Tong Zhang , Jiahong Liu , Zhihao Li , Lujia Pan , Hui Xiong , Irwin King

High-dimensional multiplex graphs are characterized by their high number of complementary and divergent dimensions. The existence of multiple hierarchical latent relations between the graph dimensions poses significant challenges to…

Machine Learning · Computer Science 2025-01-30 Kamel Abdous , Nairouz Mrabah , Mohamed Bouguessa