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Integrating the brain structural and functional connectivity features is of great significance in both exploring brain science and analyzing cognitive impairment clinically. However, it remains a challenge to effectively fuse structural and…

Neurons and Cognition · Quantitative Biology 2023-05-25 Qiankun Zuo , Baiying Lei , Ning Zhong , Yi Pan , Shuqiang Wang

Alzheimer's disease (AD) is one the main causes of dementia in the world and the patients develop severe disability and sometime full dependence. In previous stages Mild Cognitive Impairment (MCI) produces cognitive loss but not severe…

Understanding the relationship between cognition and intrinsic brain activity through purely data-driven approaches remains a significant challenge in neuroscience. Resting-state functional magnetic resonance imaging (rs-fMRI) offers a…

Machine Learning · Computer Science 2024-11-01 Yutong Gao , Vince D. Calhoun , Robyn L. Miller

Alzheimer's disease (AD) and its prodromal stage, Mild Cognitive Impairment (MCI), are associated with subtle declines in memory, attention, and language that often go undetected until late in progression. Traditional diagnostic tools such…

Human-Computer Interaction · Computer Science 2025-12-30 Ananya Drishti , Mahfuza Farooque

Deep learning methods are increasingly being used with neuroimaging data like structural and function magnetic resonance imaging (MRI) to predict the diagnosis of neuropsychiatric and neurological disorders. For psychiatric disorders in…

Neurons and Cognition · Quantitative Biology 2019-07-03 Ahmed El Gazzar , Leonardo Cerliani , Guido van Wingen , Rajat Mani Thomas

Computer-aided early diagnosis of Alzheimer's disease (AD) and its prodromal form mild cognitive impairment (MCI) based on structure Magnetic Resonance Imaging (sMRI) has provided a cost-effective and objective way for early prevention and…

Image and Video Processing · Electrical Eng. & Systems 2021-11-16 Xin Zhang , Liangxiu Han , Wenyong Zhu , Liang Sun , Daoqiang Zhang

Alzheimer's disease (AD) is a common neurodegenerative disease among the elderly. Early prediction and timely intervention of its prodromal stage, mild cognitive impairment (MCI), can decrease the risk of advancing to AD. Combining…

Image and Video Processing · Electrical Eng. & Systems 2025-01-22 Xiangyang Hu , Xiangyu Shen , Yifei Sun , Xuhao Shan , Wenwen Min , Liyilei Su , Xiaomao Fan , Ahmed Elazab , Ruiquan Ge , Changmiao Wang , Xiaopeng Fan

Alzheimer's disease (AD) is a neurodegenerative disorder that affects more than seven million people in the United States alone. AD currently has no cure, but there are ways to potentially slow its progression if caught early enough. In…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Mahdi Moghaddami , Mohammad-Reza Siadat , Austin Toma , Connor Laming , Huirong Fu

This paper proposes a novel approach of integrating different neuroimaging techniques to characterize an autistic brain. Different techniques like EEG, fMRI and DTI have traditionally been used to find biomarkers for autism, but there have…

Predicting disease states from functional brain connectivity is critical for the early diagnosis of severe neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease. Existing studies commonly employ Graph Neural…

Machine Learning · Computer Science 2025-04-22 David Yang , Mostafa Abdelmegeed , John Modl , Minjeong Kim

Deep learning has become an important tool for Alzheimer's disease (AD) classification from structural MRI. Many existing studies analyze individual 2D slices extracted from MRI volumes, while clinical neuroimaging practice typically relies…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Md Sifat , Sania Akter , Akif Islam , Md. Ekramul Hamid , Abu Saleh Musa Miah , Najmul Hassan , Md Abdur Rahim , Jungpil Shin

Alzheimer's disease (AD) is a neurodegenerative disease known to affect brain functional connectivity (FC). Linear FC measures have been applied to study the differences in AD by splitting neurophysiological signals such as…

Neurons and Cognition · Quantitative Biology 2022-06-14 Dominik Klepl , Fei He , Min Wu , Daniel J. Blackburn , Ptolemaios G. Sarrigiannis

Alzheimer's disease (AD) is a progressive brain disorder that causes memory and functional impairments. The advances in machine learning and publicly available medical datasets initiated multiple studies in AD diagnosis. In this work, we…

Image and Video Processing · Electrical Eng. & Systems 2021-07-20 Aidana Massalimova , Huseyin Atakan Varol

Resting-state fMRI has become a valuable tool for classifying brain disorders and constructing brain functional connectivity networks by tracking BOLD signals across brain regions. However, existing mod els largely neglect the…

Machine Learning · Computer Science 2025-11-18 Yue Xun , Jiaxing Xu , Wenbo Gao , Chen Yang , Shujun Wang

Mild Cognitive Impairment (MCI) serves as a prodromal stage of Alzheimer's Disease (AD), where early identification and intervention can effectively slow the progression to dementia. However, diagnosing AD remains a significant challenge in…

Artificial Intelligence · Computer Science 2025-11-07 Yutao Jin , Haowen Xiao , Junyong Zhai , Yuxiao Li , Jielei Chu , Fengmao Lv , Yuxiao Li

Analysis and quantification of brain structural changes, using Magnetic resonance imaging (MRI), are increasingly used to define novel biomarkers of brain pathologies, such as Alzheimer's disease (AD). Network-based models of the brain have…

Human brain functional connectivity (FC) is often measured as the similarity of functional MRI responses across brain regions when a brain is either resting or performing a task. This paper aims to statistically analyze the dynamic nature…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Mengyu Dai , Zhengwu Zhang , Anuj Srivastava

Current neuroimaging techniques provide paths to investigate the structure and function of the brain in vivo and have made great advances in understanding Alzheimer's disease (AD). However, the group-level analyses prevalently used for…

Quantitative Methods · Quantitative Biology 2021-05-31 Nanyan Zhu , Chen Liu , Xinyang Feng , Dipika Sikka , Sabrina Gjerswold-Selleck , Scott A. Small , Jia Guo

Accurate prediction of conversion from Mild Cognitive Impairment (MCI) to Alzheimers Diseases (AD) is essential for early intervention, however, developing reliable conversion predictive models is difficult to develop due to limited…

Artificial Intelligence · Computer Science 2026-05-21 Brad Ye , Bulent Soykan , Gulsah Hancerliogullari Koksalmis , Hsin-Hsiung Huang , Laura J. Brattain

Functional connectivity (FC) has been widely used to study brain network interactions underlying the emerging cognition and behavior of an individual. FC is usually defined as the correlation or partial correlation between brain regions.…

Applications · Statistics 2020-10-27 Gemeng Zhang , Aiying Zhang , Biao Cai , Zhuozhuo Tu , Vince D. Calhoun , Yu-Ping Wang
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