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Foundation models in digital pathology use massive datasets to learn useful compact feature representations of complex histology images. However, there is limited transparency into what drives the correlation between dataset size and…

Pathology foundation models (FMs) have driven significant progress in computational pathology. However, these high-performing models can easily exceed a billion parameters and produce high-dimensional embeddings, thus limiting their…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Christian Grashei , Christian Brechenmacher , Rao Muhammad Umer , Jingsong Liu , Carsten Marr , Ewa Szczurek , Peter J. Schüffler

Recent studies in pathology foundation models have shown that scaling training data, diversifying cancer types, and increasing model size consistently improve their performance. However, giga-scale foundation models, which are trained on…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Yesung Cho , Sungmin Lee , Geongyu Lee , Minkyung Lee , Jongbae Park , Dongmyung Shin

Pathology foundation models (PFMs) have recently emerged as powerful pretrained encoders for computational pathology, enabling transfer learning across a wide range of downstream tasks. However, systematic comparisons of these models for…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Fredrik K. Gustafsson , Constance Boissin , Johan Vallon-Christersson , David A. Clifton , Mattias Rantalainen

Foundation models have substantially advanced computational pathology by learning transferable visual representations from large histological datasets, yet their performance varies widely across tasks due to differences in training data…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Wenhui Lei , Yusheng Tan , Anqi Li , Hanyu Chen , Hengrui Tian , Ruiying Li , Zhengqun Jiang , Fang Yan , Xiaofan Zhang , Shaoting Zhang

Deploying large language models (LLMs) is challenging because they are memory inefficient and compute-intensive for practical applications. In reaction, researchers train smaller task-specific models by either finetuning with human labels…

Computation and Language · Computer Science 2023-07-06 Cheng-Yu Hsieh , Chun-Liang Li , Chih-Kuan Yeh , Hootan Nakhost , Yasuhisa Fujii , Alexander Ratner , Ranjay Krishna , Chen-Yu Lee , Tomas Pfister

The deployment of foundation models for medical imaging has demonstrated considerable success. However, their training overheads associated with downstream tasks remain substantial due to the size of the image encoders employed, and the…

Computer Vision and Pattern Recognition · Computer Science 2025-04-04 Chengxi Zeng , Yuxuan Jiang , Fan Zhang , Alberto Gambaruto , Tilo Burghardt

The field of computational pathology has recently seen rapid advances driven by the development of modern vision foundation models (FMs), typically trained on vast collections of pathology images. Recent studies demonstrate that increasing…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Mikhail Karasikov , Joost van Doorn , Nicolas Känzig , Melis Erdal Cesur , Hugo Mark Horlings , Robert Berke , Fei Tang , Sebastian Otálora

Deploying medical image segmentation models in routine clinical workflows is often constrained by on-premises infrastructure, where computational resources are fixed and cloud-based inference may be restricted by governance and security…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Qizhen Lan , Aaron Choi , Jun Ma , Bo Wang , Zhaogming Zhao , Xiaoqian Jiang , Yu-Chun Hsu

Machine-learned interatomic potentials have transformed computational research in the physical sciences. Recent atomistic `foundation' models have changed the field yet again: trained on many different chemical elements and domains, these…

Foundation models (FM) have transformed computational pathology but remain computationally prohibitive for clinical deployment due to their massive parameter counts and high-magnification processing requirements. Here, we introduce XMAG, a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Ziyu Su , Abdul Rehman Akbar , Usama Sajjad , Anil V. Parwani , Muhammad Khalid Khan Niazi

Foundation models pretrained on large-scale datasets are revolutionizing the field of computational pathology (CPath). The generalization ability of foundation models is crucial for the success in various downstream clinical tasks. However,…

Large Vision-Language Foundation Models (VLFM), such as CLIP, ALIGN and Florence, are trained on large-scale datasets of image-caption pairs and achieve superior transferability and robustness on downstream tasks, but they are difficult to…

Computer Vision and Pattern Recognition · Computer Science 2023-08-16 Ximeng Sun , Pengchuan Zhang , Peizhao Zhang , Hardik Shah , Kate Saenko , Xide Xia

The foundation model (FM) paradigm is transforming Machine Learning Force Fields (MLFFs), leveraging general-purpose representations and scalable training to perform a variety of computational chemistry tasks. Although MLFF FMs have begun…

Chemical Physics · Physics 2025-02-03 Ishan Amin , Sanjeev Raja , Aditi Krishnapriyan

Foundation Models (FMs) have demonstrated strong generalization across diverse vision tasks. However, their deployment in federated settings is hindered by high computational demands, substantial communication overhead, and significant…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Hanwen Zhang , Qiaojin Shen , Yuxi Liu , Yuesheng Zhu , Guibo Luo

Histopathology can help clinicians make accurate diagnoses, determine disease prognosis, and plan appropriate treatment strategies. As deep learning techniques prove successful in the medical domain, the primary challenges become limited…

Computer Vision and Pattern Recognition · Computer Science 2024-07-11 Zhe Li , Bernhard Kainz

Federated Learning (FL) is a distributed training paradigm that enables clients scattered across the world to cooperatively learn a global model without divulging confidential data. However, FL faces a significant challenge in the form of…

Machine Learning · Computer Science 2023-11-16 Xidong Wu , Wan-Yi Lin , Devin Willmott , Filipe Condessa , Yufei Huang , Zhenzhen Li , Madan Ravi Ganesh

Large Genomic Foundation Models have recently achieved remarkable results and in-vivo translation capabilities. However these models quickly grow to over a few Billion of parameters and are expensive to run when compute is limited. To…

Machine Learning · Computer Science 2026-04-13 Rasched Haidari , Sam Martin , Maxime Allard

Although more layers and more parameters generally improve the accuracy of the models, such big models generally have high computational complexity and require big memory, which exceed the capacity of small devices for inference and incurs…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-07-15 Ji Liu , Daxiang Dong , Xi Wang , An Qin , Xingjian Li , Patrick Valduriez , Dejing Dou , Dianhai Yu

Masked image modeling (MIM) performs strongly in pre-training large vision Transformers (ViTs). However, small models that are critical for real-world applications cannot or only marginally benefit from this pre-training approach. In this…

Computer Vision and Pattern Recognition · Computer Science 2023-01-04 Sucheng Ren , Fangyun Wei , Zheng Zhang , Han Hu
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