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In this paper, we propose that small models may not need to absorb the cost of pre-training to reap its benefits. Instead, they can capitalize on the astonishing results achieved by modern, enormous models to a surprising degree. We observe…

Machine Learning · Computer Science 2024-05-06 Sean Farhat , Deming Chen

Large language models (LLMs) excel at clinical information extraction but their computational demands limit practical deployment. Knowledge distillation--the process of transferring knowledge from larger to smaller models--offers a…

Computation and Language · Computer Science 2025-01-03 Karthik S. Vedula , Annika Gupta , Akshay Swaminathan , Ivan Lopez , Suhana Bedi , Nigam H. Shah

Time Series foundation models (TSFMs) deliver strong forecasting performance through large-scale pretraining, but their large parameter sizes make deployment costly. While knowledge distillation offers a natural and effective approach for…

Machine Learning · Computer Science 2026-01-21 Yuqi Li , Kuiye Ding , Chuanguang Yang , Szu-Yu Chen , Yingli Tian

Foundation models for medical imaging demonstrate superior generalization capabilities across diverse anatomical structures and clinical applications. Their outstanding performance relies on substantial computational resources, limiting…

Image and Video Processing · Electrical Eng. & Systems 2026-04-15 Chen Ma , Jing Jiao , Shuyu Liang , Junhu Fu , Qin Wang , Zeju Li , Yuanyuan Wang , Yi Guo

Computational pathology, which involves analyzing whole slide images for automated cancer diagnosis, relies on multiple instance learning, where performance depends heavily on the feature extractor and aggregator. Recent Pathology…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Conghao Xiong , Hao Chen , Joseph J. Y. Sung

Techniques such as ensembling and distillation promise model quality improvements when paired with almost any base model. However, due to increased test-time cost (for ensembles) and increased complexity of the training pipeline (for…

Machine Learning · Computer Science 2020-08-24 Rohan Anil , Gabriel Pereyra , Alexandre Passos , Robert Ormandi , George E. Dahl , Geoffrey E. Hinton

Dataset distillation reduces the network training cost by synthesizing small and informative datasets from large-scale ones. Despite the success of the recent dataset distillation algorithms, three drawbacks still limit their wider…

Computer Vision and Pattern Recognition · Computer Science 2023-10-12 Kai Wang , Jianyang Gu , Daquan Zhou , Zheng Zhu , Wei Jiang , Yang You

Dataset distillation aims to distill the knowledge of a large-scale real dataset into small yet informative synthetic data such that a model trained on it performs as well as a model trained on the full dataset. Despite recent progress,…

Computer Vision and Pattern Recognition · Computer Science 2024-11-21 Ahmad Sajedi , Samir Khaki , Lucy Z. Liu , Ehsan Amjadian , Yuri A. Lawryshyn , Konstantinos N. Plataniotis

Diffusion Models~(DMs) have emerged as the dominant approach in Generative Artificial Intelligence (GenAI), owing to their remarkable performance in tasks such as text-to-image synthesis. However, practical DMs, such as stable diffusion,…

Machine Learning · Computer Science 2025-08-18 Xuhui Fan , Zhangkai Wu , Hongyu Wu

Pretraining on large-scale, in-domain datasets grants histopathology foundation models (FM) the ability to learn task-agnostic data representations, enhancing transfer learning on downstream tasks. In computational pathology, automated…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Pablo Meseguer , Rocío del Amor , Valery Naranjo

Digital pathology has significantly advanced disease detection and pathologist efficiency through the analysis of gigapixel whole-slide images (WSI). In this process, WSIs are first divided into patches, for which a feature extractor model…

Computer Vision and Pattern Recognition · Computer Science 2024-08-05 Gustav Bredell , Marcel Fischer , Przemyslaw Szostak , Samaneh Abbasi-Sureshjani , Alvaro Gomariz

Developing clinically useful cell-level analysis tools in digital pathology remains challenging due to limitations in dataset granularity, inconsistent annotations, high computational demands, and difficulties integrating new technologies…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Nikita Shvetsov , Thomas K. Kilvaer , Masoud Tafavvoghi , Anders Sildnes , Kajsa Møllersen , Lill-Tove Rasmussen Busund , Lars Ailo Bongo

Top-performing machine learning systems, such as deep neural networks, large ensembles and complex probabilistic graphical models, can be expensive to store, slow to evaluate and hard to integrate into larger systems. Ideally, we would like…

Machine Learning · Statistics 2015-10-09 George Papamakarios

The development of computer vision solutions for gigapixel images in digital pathology is hampered by significant computational limitations due to the large size of whole slide images. In particular, digitizing biopsies at high resolutions…

Computer Vision and Pattern Recognition · Computer Science 2024-01-12 Rocío del Amor , Julio Silva-Rodríguez , Adrián Colomer , Valery Naranjo

Model distillation aims to distill the knowledge of a complex model into a simpler one. In this paper, we consider an alternative formulation called dataset distillation: we keep the model fixed and instead attempt to distill the knowledge…

Machine Learning · Computer Science 2020-02-26 Tongzhou Wang , Jun-Yan Zhu , Antonio Torralba , Alexei A. Efros

Medical foundation models pre-trained on large-scale datasets have demonstrated powerful versatile capabilities for various tasks. However, due to the gap between pre-training tasks (or modalities) and downstream tasks (or modalities), the…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Yuhang Zhou , Siyuan Du , Haolin Li , Jiangchao Yao , Ya Zhang , Yanfeng Wang

Tabular foundation models (TFMs) achieve strong performance on health datasets, but their inference cost and infrastructure requirements limit practical use. We study whether their predictive behavior can be transferred to lightweight…

Machine Learning · Computer Science 2026-05-19 Aditya Tanna , Nassim Bouarour , Mohamed Bouadi , Vinay Kumar Sankarapu , Pratinav Seth

Diffusion models produce high-quality text-to-image results, but their iterative denoising is computationally expensive.Distribution Matching Distillation (DMD) emerges as a promising path to few-step distillation, but suffers from…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Haoyu Li , Tingyan Wen , Lin Qi , Zhe Wu , Yihuang Chen , Xing Zhou , Lifei Zhu , Xueqian Wang , Kai Zhang

Since the advent of reasoning-based large language models, many have found great success from distilling reasoning capabilities into student models. Such techniques have significantly bridged the gap between reasoning and standard LLMs on…

Foundation models trained with self-supervised learning (SSL) on large-scale histological images have significantly accelerated the development of computational pathology. These models can serve as backbones for region-of-interest (ROI)…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Jiawen Li , Jiali Hu , Xitong Ling , Yongqiang Lv , Yuxuan Chen , Yizhi Wang , Tian Guan , Yifei Liu , Yonghong He