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Synthetic data generation is a promising solution to address privacy issues with the distribution of sensitive health data. Recently, diffusion models have set new standards for generative models for different data modalities. Also very…

Signal Processing · Electrical Eng. & Systems 2023-06-16 Juan Miguel Lopez Alcaraz , Nils Strodthoff

We present a self-supervised algorithm for several classification tasks within hematoxylin and eosin (H&E) stained images of breast cancer. Our method is robust to stain variations inherent to the histology images acquisition process, which…

Computer Vision and Pattern Recognition · Computer Science 2023-09-08 Alexandre Tiard , Alex Wong , David Joon Ho , Yangchao Wu , Eliram Nof , Alvin C. Goh , Stefano Soatto , Saad Nadeem

Diffusion models have demonstrated their effectiveness across various generative tasks. However, when applied to medical image segmentation, these models encounter several challenges, including significant resource and time requirements.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Tianyu Lin , Zhiguang Chen , Zhonghao Yan , Weijiang Yu , Fudan Zheng

Generating graph-structured data requires learning the underlying distribution of graphs. Yet, this is a challenging problem, and the previous graph generative methods either fail to capture the permutation-invariance property of graphs or…

Machine Learning · Computer Science 2022-06-16 Jaehyeong Jo , Seul Lee , Sung Ju Hwang

Spatio-temporal processes often exhibit highly heterogeneous and non-intuitive responses to localized disruptions, limiting the effectiveness of conventional message passing approaches in modeling local heterogeneity. We reformulate…

Machine Learning · Computer Science 2026-04-21 Abeer Mostafa , Raneen Younis , Zahra Ahmadi

Recent advancements in diffusion models have significantly improved performance in super-resolution (SR) tasks. However, previous research often overlooks the fundamental differences between SR and general image generation. General image…

Image and Video Processing · Electrical Eng. & Systems 2024-10-31 Hanlin Wu , Jiangwei Mo , Xiaohui Sun , Jie Ma

We introduce Seed-to-Seed Translation (StS), a novel approach for Image-to-Image Translation using diffusion models (DMs), aimed at translations that require close adherence to the structure of the source image. In contrast to existing…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Or Greenberg , Eran Kishon , Dani Lischinski

Histopathology image classification is crucial for the accurate identification and diagnosis of various diseases but requires large and diverse datasets. Obtaining such datasets, however, is often costly and time-consuming due to the need…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Leire Benito-Del-Valle , Aitor Alvarez-Gila , Itziar Eguskiza , Cristina L. Saratxaga

Cellular identity and function are linked to both their intrinsic genomic makeup and extrinsic spatial context within the tissue microenvironment. Spatial transcriptomics (ST) offers an unprecedented opportunity to study this, providing in…

Machine Learning · Computer Science 2026-02-16 Rui Yan , Xiaohan Xing , Xun Wang , Zixia Zhou , Md Tauhidul Islam , Lei Xing

Spatial transcriptomics enables gene expression profiling with spatial context, offering unprecedented insights into the tissue microenvironment. However, most computational models treat genes as isolated numerical features, ignoring the…

Machine Learning · Computer Science 2025-11-17 Jiangkai Long , Yanran Zhu , Chang Tang , Kun Sun , Yuanyuan Liu , Xuesong Yan

Data augmentation effectively addresses the imbalanced-small sample data (ISSD) problem in hyperspectral image classification (HSIC). While most methodologies extend features in the latent space, few leverage text-driven generation to…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Yimin Zhu , Lincoln Linlin Xu

Synthesizing realistic microstructure images conditioned on processing parameters is crucial for understanding process-structure relationships in materials design. However, this task remains challenging due to limited training micrographs…

Materials Science · Physics 2025-11-21 Hoang Cuong Phan , Minh Tien Tran , Chihun Lee , Hoheok Kim , Sehyeok Oh , Dong-Kyu Kim , Ho Won Lee

Histopathology tissue samples are widely available in two states: paraffin-embedded unstained and non-paraffin-embedded stained whole slide RGB images (WSRI). Hematoxylin and eosin stain (H&E) is one of the principal stains in histology but…

Computer Vision and Pattern Recognition · Computer Science 2019-02-21 Aman Rana , Gregory Yauney , Alarice Lowe , Pratik Shah

Generative modeling and clustering are conventionally distinct tasks in machine learning. Variational Autoencoders (VAEs) have been widely explored for their ability to integrate both, providing a framework for generative clustering.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Jorge da Silva Gonçalves , Laura Manduchi , Moritz Vandenhirtz , Julia E. Vogt

Chemical staining methods are dependable but require extensive time, expensive chemicals, and raise environmental concerns. These challenges highlight the need for alternative solutions like virtual staining, which accelerates the…

Image and Video Processing · Electrical Eng. & Systems 2024-07-02 Mehdi Ounissi , Ilias Sarbout , Jean-Pierre Hugot , Christine Martinez-Vinson , Dominique Berrebi , Daniel Racoceanu

Virtual staining streamlines traditional staining procedures by digitally generating stained images from unstained or differently stained images. While conventional staining methods involve time-consuming chemical processes, virtual…

Diffusion models have shown a great ability at bridging the performance gap between predictive and generative approaches for speech enhancement. We have shown that they may even outperform their predictive counterparts for non-additive…

Audio and Speech Processing · Electrical Eng. & Systems 2024-03-13 Jean-Marie Lemercier , Julius Richter , Simon Welker , Timo Gerkmann

Diffusion models (DMs) represent state-of-the-art generative models for continuous inputs. DMs work by constructing a Stochastic Differential Equation (SDE) in the input space (ie, position space), and using a neural network to reverse it.…

Machine Learning · Computer Science 2024-05-14 Tianrong Chen , Jiatao Gu , Laurent Dinh , Evangelos A. Theodorou , Joshua Susskind , Shuangfei Zhai

A recent technology breakthrough in spatial molecular profiling has enabled the comprehensive molecular characterizations of single cells while preserving spatial information. It provides new opportunities to delineate how cells from…

Applications · Statistics 2021-10-07 Xi Jiang , Qiwei Li , Guanghua Xiao

Diffusion model, as a new generative model which is very popular in image generation and audio synthesis, is rarely used in speech enhancement. In this paper, we use the diffusion model as a module for stochastic refinement. We propose…

Sound · Computer Science 2022-11-01 Zhibin Qiu , Mengfan Fu , Yinfeng Yu , LiLi Yin , Fuchun Sun , Hao Huang