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Molecule-and-text cross-modal representation learning has emerged as a promising direction for enhancing the quality of molecular representation, thereby improving performance in various scientific fields. However, most approaches employ a…

Quantitative Methods · Quantitative Biology 2025-03-04 Yikun Zhang , Geyan Ye , Chaohao Yuan , Bo Han , Long-Kai Huang , Jianhua Yao , Wei Liu , Yu Rong

In Document Understanding, the challenge of reconstructing damaged, occluded, or incomplete text remains a critical yet unexplored problem. Subsequent document understanding tasks can benefit from a document reconstruction process. In…

Computer Vision and Pattern Recognition · Computer Science 2026-05-25 Kunal Purkayastha , Ayan Banerjee , Josep Llados , Umapada Pal

Modern computational organic chemistry is becoming increasingly data-driven. There remain a large number of important unsolved problems in this area such as product prediction given reactants, drug discovery, and metric-optimized molecule…

Biomolecules · Quantitative Biology 2026-02-10 Josh Payne , Mario Srouji , Dian Ang Yap , Vineet Kosaraju

Multimodal models, such as the Contrastive Language-Image Pre-training (CLIP) model, have demonstrated remarkable success in aligning visual and linguistic representations. However, these models exhibit limitations when applied to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-02 Hiroshi Sasaki

Stereoisomers have the same molecular formula and the same atom connectivity and their existence can be related to the presence of different three-dimensional arrangements. Stereoisomerism is of great importance in many different fields…

Computational Engineering, Finance, and Science · Computer Science 2013-03-08 Ana L. Teixeira , João P. Leal , Andre O Falcao

Pharmaceutical analysis, as the core curriculum of chemistry, chemical engineering and pharmaceutical engineering, contains broad and in-depth knowledge that leads to massive learning & teaching loads. There are more than 100 analytical…

Physics Education · Physics 2022-09-21 Hui Zhenga , Binjing Hu , Qiang Sun , Jun Cao , Fangmin Liu

Recent open-vocabulary detection methods aim to detect novel objects by distilling knowledge from vision-language models (VLMs) trained on a vast amount of image-text pairs. To improve the effectiveness of these methods, researchers have…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Han-Cheol Cho , Won Young Jhoo , Wooyoung Kang , Byungseok Roh

Introduction: molecular geometry, the three-dimensional arrangement of atoms within a molecule, is fundamental to understanding chemical reactivity, physical properties, and biological activity. The prevailing models used to describe…

General Physics · Physics 2026-05-12 Sebastian Ali Sacasa-Cespedes

Drug discovery aims to find novel compounds with specified chemical property profiles. In terms of generative modeling, the goal is to learn to sample molecules in the intersection of multiple property constraints. This task becomes…

Machine Learning · Computer Science 2020-07-06 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Medical image segmentation, or computing voxelwise semantic masks, is a fundamental yet challenging task to compute a voxel-level semantic mask. To increase the ability of encoder-decoder neural networks to perform this task across large…

Computer Vision and Pattern Recognition · Computer Science 2021-11-10 Ho Hin Lee , Yucheng Tang , Qi Yang , Xin Yu , Shunxing Bao , Leon Y. Cai , Lucas W. Remedios , Bennett A. Landman , Yuankai Huo

Open-vocabulary image semantic segmentation (OVS) seeks to segment images into semantic regions across an open set of categories. Existing OVS methods commonly depend on foundational vision-language models and utilize similarity computation…

Computer Vision and Pattern Recognition · Computer Science 2024-09-13 Qinglong Cao , Yuntian Chen , Chao Ma , Xiaokang Yang

Rapid overlay of chemical structures (ROCS) is a standard tool for the calculation of 3D shape and chemical ("color") similarity. ROCS uses unweighted sums to combine many aspects of similarity, yielding parameter-free models for virtual…

Machine Learning · Statistics 2016-09-13 Steven Kearnes , Vijay Pande

Predicting molecular properties is essential for drug discovery, and computational methods can greatly enhance this process. Molecular graphs have become a focus for representation learning, with Graph Neural Networks (GNNs) widely used.…

Machine Learning · Computer Science 2025-01-31 Yan Sun , Yutong Lu , Yan Yi Li , Zihao Jing , Carson K. Leung , Pingzhao Hu

Large-scale chemical reaction datasets are crucial for AI research in chemistry. However, existing chemical reaction data often exist as images within papers, making them not machine-readable and unusable for training machine learning…

Computer Vision and Pattern Recognition · Computer Science 2026-01-07 Jiahe Song , Chuang Wang , Bowen Jiang , Yinfan Wang , Hao Zheng , Xingjian Wei , Chengjin Liu , Rui Nie , Junyuan Gao , Jiaxing Sun , Yubin Wang , Lijun Wu , Zhenhua Huang , Jiang Wu , Qian Yu , Conghui He

Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful and widely used tools for molecular structure elucidation in organic chemistry. However, the interpretation of NMR spectra to determine unknown molecular structures…

Chemical Physics · Physics 2025-09-03 Yongqi Jin , Jun-Jie Wang , Fanjie Xu , Xiaohong Ji , Zhifeng Gao , Linfeng Zhang , Guolin Ke , Rong Zhu , Weinan E

A major limitation and a continuing source of confusion in the interpretation of molecular line observations has been the large degree of chemical complexity that is observed in star-forming molecular cores. The past decade has seen…

Astrophysics · Physics 2017-01-18 Edwin A. Bergin

Determining the structure and following the structural evolution of molecules undergoing chemical reactions is one of the key goals of ultrafast molecular physics and chemistry. Recently, Coulomb explosion imaging has emerged as a promising…

The Object-Based Image Coding (OBIC) that was extensively studied about two decades ago, promised a vast application perspective for both ultra-low bitrate communication and high-level semantical content understanding, but it had rarely…

Image and Video Processing · Electrical Eng. & Systems 2020-03-20 Qi Xia , Haojie Liu , Zhan Ma

Molecular knowledge resides within three different modalities of information sources: molecular structures, biomedical documents, and knowledge bases. Effective incorporation of molecular knowledge from these modalities holds paramount…

Biomolecules · Quantitative Biology 2023-07-24 Yizhen Luo , Kai Yang , Massimo Hong , Xing Yi Liu , Zaiqing Nie

Ontologies are formal representations of knowledge in specific domains that provide a structured framework for organizing and understanding complex information. Creating ontologies, however, is a complex and time-consuming endeavor. ChEBI…

Artificial Intelligence · Computer Science 2024-08-01 Stefan Langer , Fabian Neuhaus , Andreas Nürnberger