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Enhancing cryogenic electron microscopy (cryo-EM) 3D density maps at intermediate resolution (4-8 {\AA}) is crucial in protein structure determination. Recent advances in deep learning have led to the development of automated approaches for…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Chenwei Zhang , Khanh Dao Duc

A novel neural network architecture, known as DL-ESPIRiT, is proposed to reconstruct rapidly acquired cardiac MRI data without field-of-view limitations which are present in previously proposed deep learning-based reconstruction frameworks.…

Signal Processing · Electrical Eng. & Systems 2020-05-20 Christopher M. Sandino , Peng Lai , Shreyas S. Vasanawala , Joseph Y. Cheng

Deep learning-based low-dose computed tomography reconstruction methods already achieve high performance on standard image quality metrics like peak signal-to-noise ratio and structural similarity index measure. Yet, they frequently fail to…

Image and Video Processing · Electrical Eng. & Systems 2025-11-11 Necati Sefercioglu , Mehmet Ozan Unal , Metin Ertas , Isa Yildirim

In cryo-electron microscopy, accurate particle localization and classification are imperative. Recent deep learning solutions, though successful, require extensive training data sets. The protracted generation time of physics-based models,…

Machine Learning · Computer Science 2025-02-20 Pavol Harar , Lukas Herrmann , Philipp Grohs , David Haselbach

Deep learning is having a profound impact in many fields, especially those that involve some form of image processing. Deep neural networks excel in turning an input image into a set of high-level features. On the other hand, tomography…

Machine Learning · Statistics 2017-01-03 Francisco A. Matos , Diogo R. Ferreira , Pedro J. Carvalho , JET Contributors

Cryo-electron microscopy (Cryo-EM) enables high-resolution imaging of biomolecules, but structural heterogeneity remains a major challenge in 3D reconstruction. Traditional methods assume a discrete set of conformations, limiting their…

Machine Learning · Statistics 2025-09-09 Diego Sanchez Espinosa , Erik H Thiede , Yunan Yang

Curvilinear structures frequently appear in microscopy imaging as the object of interest. Crystallographic defects, i.e., dislocations, are one of the curvilinear structures that have been repeatedly investigated under transmission electron…

Image and Video Processing · Electrical Eng. & Systems 2021-10-19 Okan Altingövde , Anastasiia Mishchuk , Gulnaz Ganeeva , Emad Oveisi , Cecile Hebert , Pascal Fua

We propose an embarrassingly simple but very effective scheme for high-quality dense stereo reconstruction: (i) generate an approximate reconstruction with your favourite stereo matcher; (ii) rewarp the input images with that approximate…

Computer Vision and Pattern Recognition · Computer Science 2021-06-21 Corinne Stucker , Konrad Schindler

Background: Image reconstruction from highly undersampled 4D flow MRI data can be very time consuming and may result in significant underestimation of velocities depending on regularization, thereby limiting the applicability of the method.…

Medical Physics · Physics 2025-04-01 Luuk Jacobs , Marco Piccirelli , Valery Vishnevskiy , Sebastian Kozerke

Cone Beam CT (CBCT) is an important imaging modality nowadays, however lower image quality of CBCT compared to more conventional Computed Tomography (CT) remains a limiting factor in CBCT applications. Deep learning reconstruction methods…

This paper studies 3D low-dose computed tomography (CT) imaging. Although various deep learning methods were developed in this context, typically they focus on 2D images and perform denoising due to low-dose and deblurring for…

Image and Video Processing · Electrical Eng. & Systems 2024-01-10 Zhihao Chen , Chuang Niu , Qi Gao , Ge Wang , Hongming Shan

Computed Tomography (CT) is widely used in healthcare for detailed imaging. However, Low-dose CT, despite reducing radiation exposure, often results in images with compromised quality due to increased noise. Traditional methods, including…

Image and Video Processing · Electrical Eng. & Systems 2024-09-17 Herman Verinaz-Jadan , Su Yan

With the onset of large-scale astronomical surveys capturing millions of images, there is an increasing need to develop fast and accurate deconvolution algorithms that generalize well to different images. A powerful and accessible…

Instrumentation and Methods for Astrophysics · Physics 2022-11-18 Utsav Akhaury , Jean-Luc Starck , Pascale Jablonka , Frédéric Courbin , Kevin Michalewicz

Accurate pose estimation and shift correction are key challenges in cryo-EM due to the very low SNR, which directly impacts the fidelity of 3D reconstructions. We present an approach for pose estimation in cryo-EM that leverages…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Kaishva Chintan Shah , Virajith Boddapati , Karthik S. Gurumoorthy , Sandip Kaledhonkar , Ajit Rajwade

We present a geometry-aware method for heterogeneous single-particle cryogenic electron microscopy (cryo-EM) reconstruction that predicts atomic backbone conformations. To incorporate protein-structure priors, we represent the backbone as a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-09 Jonathan Krook , Axel Janson , Joakim Andén , Melanie Weber , Ozan Öktem

Limited-angle electron tomography aims to reconstruct 3D shapes from 2D projections of Transmission Electron Microscopy (TEM) within a restricted range and number of tilting angles, but it suffers from the missing-wedge problem that causes…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Zhantao Deng , Mériem Er-Rafik , Anna Sushko , Cécile Hébert , Pascal Fua

Single-particle cryo-electron microscopy (cryo-EM) reconstructs the three-dimensional (3D) structure of bio-molecules from a large set of 2D projection images with random and unknown orientations. A crucial step in the single-particle…

Image and Video Processing · Electrical Eng. & Systems 2020-06-24 Mona Zehni , Laurène Donati , Emmanuel Soubies , Zhizhen J. Zhao , Michael Unser

The Cosmic Multiperspective Event Tracker (CoMET) R&D project aims to optimize the techniques for the detection of soft-spectrum sources through very-high-energy gamma-ray observations using particle detectors (called ALTO detectors), and…

Instrumentation and Methods for Astrophysics · Physics 2021-07-30 Tomas Bylund , Gašper Kukec Mezek , Mohanraj Senniappan , Yvonne Becherini , Michael Punch , Satyendra Thoudam , Jean-Pierre Ernenwein

The unrolling method has been investigated for learning variational models in X-ray computed tomography. However, it has been observed that directly unrolling the regularization model through gradient descent does not produce satisfactory…

Image and Video Processing · Electrical Eng. & Systems 2024-04-19 Yijie Yang , Qifeng Gao , Yuping Duan

The low-frequency component of the upcoming Square Kilometre Array Observatory (SKA-Low) will be sensitive enough to construct 3D tomographic images of the 21-cm signal distribution during reionisation. However, foreground contamination…