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Single-particle cryo-electron microscopy (cryo-EM) is an emerging imaging modality capable of visualizing proteins and macro-molecular complexes at near-atomic resolution. The low electron-doses used to prevent sample radiation damage,…

Image and Video Processing · Electrical Eng. & Systems 2020-11-24 Qinwen Huang , Ye Zhou , Xiaochen Du , Reed Chen , Jianyou Wang , Cynthia Rudin , Alberto Bartesaghi

Tomographic synthetic aperture radar (TomoSAR) imaging algorithms based on deep learning can effectively reduce computational costs. The idea of existing researches is to reconstruct the elevation for each range-azimuth cell in…

Signal Processing · Electrical Eng. & Systems 2022-10-06 Yu Ren , Xiaoling Zhang , Yunqiao Hu , Xu Zhan

The central problem in cryo-electron microscopy (cryo-EM) is to recover the 3D structure from noisy 2D projection images which requires estimating the missing projection angles (poses). Recent methods attempted to solve the 3D…

Computer Vision and Pattern Recognition · Computer Science 2023-02-15 Lin Yao , Ruihan Xu , Zhifeng Gao , Guolin Ke , Yuhang Wang

This study presents a novel approach for reconstructing cone beam computed tomography (CBCT) for specific orbits using known operator learning. Unlike traditional methods, this technique employs a filtered backprojection type (FBP-type)…

Computer Vision and Pattern Recognition · Computer Science 2024-03-04 Chengze Ye , Linda-Sophie Schneider , Yipeng Sun , Andreas Maier

Determining the three-dimensional structure of proteins and protein complexes at atomic resolution is a fundamental task in structural biology. Over the last decade, remarkable progress has been made using "single particle" cryo-electron…

Numerical Analysis · Mathematics 2017-06-05 Alex Barnett , Leslie Greengard , Andras Pataki , Marina Spivak

Deep neural networks based on unrolled iterative algorithms have achieved remarkable success in sparse reconstruction applications, such as synthetic aperture radar (SAR) tomographic inversion (TomoSAR). However, the currently available…

Signal Processing · Electrical Eng. & Systems 2026-04-22 Kun Qian , Yuanyuan Wang , Peter Jung , Yilei Shi , Xiao Xiang Zhu

Cryo-electron microscopy (cryo-EM), the subject of the 2017 Nobel Prize in Chemistry, is a technology for determining the 3-D structure of macromolecules from many noisy 2-D projections of instances of these macromolecules, whose…

Computer Vision and Pattern Recognition · Computer Science 2020-04-22 Roy R. Lederman , Joakim Andén , Amit Singer

Histologic examination plays a crucial role in oncology research and diagnostics. The adoption of digital scanning of whole slide images (WSI) has created an opportunity to leverage deep learning-based image classification methods to…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Md Zahangir Alom , Quynh T. Tran , Brent A. Orr

Motivation: Cryo-Electron Tomography (cryo-ET) visualizes structure and spatial organization of macromolecules and their interactions with other subcellular components inside single cells in the close-to-native state at sub-molecular…

Quantitative Methods · Quantitative Biology 2020-07-31 Liangyong Yu , Ran Li , Xiangrui Zeng , Hongyi Wang , Jie Jin , Ge Yang , Rui Jiang , Min Xu

Cryo-electron microscopy (cryo-EM) is an imaging modality that provides unique insights into the dynamics of proteins and other building blocks of life. The algorithmic challenge of jointly estimating the poses, 3D structure, and…

Computer Vision and Pattern Recognition · Computer Science 2022-10-17 Axel Levy , Gordon Wetzstein , Julien Martel , Frederic Poitevin , Ellen D. Zhong

Sparse-view cone-beam CT (CBCT) reconstruction is an important direction to reduce radiation dose and benefit clinical applications. Previous voxel-based generation methods represent the CT as discrete voxels, resulting in high memory…

Image and Video Processing · Electrical Eng. & Systems 2023-09-01 Yiqun Lin , Zhongjin Luo , Wei Zhao , Xiaomeng Li

The cryo-electron microscope (cryo-EM) is increasingly popular these years. It helps to uncover the biological structures and functions of macromolecules. In this paper, we address image denoising problem in cryo-EM. Denoising the cryo-EM…

Computation · Statistics 2018-10-26 Yin Xian , Hanlin Gu , Wei Wang , Xuhui Huang , Yuan Yao , Yang Wang , Jian-Feng Cai

At X-ray beamlines of synchrotron light sources, the achievable time-resolution for 3D tomographic imaging of the interior of an object has been reduced to a fraction of a second, enabling rapidly changing structures to be examined. The…

Image and Video Processing · Electrical Eng. & Systems 2020-07-06 Marinus J. Lagerwerf , Allard A. Hendriksen , Jan-Willem Buurlage , K. Joost Batenburg

Pose estimation from unordered images is fundamental for 3D reconstruction, robotics, and scientific imaging. Recent geometric foundation models, such as DUSt3R, enable end-to-end dense 3D reconstruction but remain underexplored in…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Jiakai Zhang , Shouchen Zhou , Haizhao Dai , Xinhang Liu , Peihao Wang , Zhiwen Fan , Yuan Pei , Jingyi Yu

Discovering the 3D atomic structure of molecules such as proteins and viruses is a fundamental research problem in biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising vision-based technique for structure estimation which…

Computer Vision and Pattern Recognition · Computer Science 2016-11-18 Marcus A. Brubaker , Ali Punjani , David J. Fleet

Single-particle electron cryomicroscopy is an essential tool for high-resolution 3D reconstruction of proteins and other biological macromolecules. An important challenge in cryo-EM is the reconstruction of non-rigid molecules with parts…

Image and Video Processing · Electrical Eng. & Systems 2021-05-31 Amit Moscovich , Amit Halevi , Joakim Andén , Amit Singer

The development of fast and accurate image reconstruction algorithms is a central aspect of computed tomography. In this paper, we investigate this issue for the sparse data problem in photoacoustic tomography (PAT). We develop a direct and…

Computer Vision and Pattern Recognition · Computer Science 2018-08-31 Stephan Antholzer , Markus Haltmeier , Johannes Schwab

Electrical Impedance Tomography (EIT) is a non-invasive, low-cost bedside imaging modality with high temporal resolution, making it suitable for bedside monitoring. However, its inherently ill-posed inverse problem poses significant…

Computer Vision and Pattern Recognition · Computer Science 2025-07-21 Hao Fang , Sihao Teng , Hao Yu , Siyi Yuan , Huaiwu He , Zhe Liu , Yunjie Yang

Deep Learning can significantly benefit cancer proteomics and genomics. In this study, we attempt to determine a set of critical proteins that are associated with the FLT3-ITD mutation in newly-diagnosed acute myeloid leukemia patients. A…

Quantitative Methods · Quantitative Biology 2018-01-04 Christine A. Liang , Lei Chen , Amer Wahed , Andy N. D. Nguyen

Breast CT provides image volumes with isotropic resolution in high contrast, enabling detection of small calcification (down to a few hundred microns in size) and subtle density differences. Since breast is sensitive to x-ray radiation,…

Image and Video Processing · Electrical Eng. & Systems 2020-11-05 Huidong Xie , Hongming Shan , Wenxiang Cong , Chi Liu , Xiaohua Zhang , Shaohua Liu , Ruola Ning , Ge Wang
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