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The fluorescence microscope is one of the most important tools in modern clinical diagnosis and biological science. However, its expense, size and limited field-of-view (FOV) are becoming bottlenecks in key applications such as large-scale…

Optics · Physics 2012-10-10 Shuo Pang , Chao Han , Mihoko Kato , Paul W. Sternberg , Changhuei Yang

Plenoptic cameras use arrays of micro-lenses to capture multiple views of the same scene in a single compound image. They enable refocusing on different planes and depth estimation. However, until now, all types of plenoptic computational…

Optics · Physics 2020-01-29 K. M. Sowa , M. P. Kujda , P. Korecki

Holographic microscopy presents challenges for color reproduction due to the usage of narrow-band illumination sources, which especially impacts the imaging of stained pathology slides for clinical diagnoses. Here, an accurate color…

Medical Physics · Physics 2019-03-06 Yibo Zhang , Tairan Liu , Yujia Huang , Da Teng , Yinxu Bian , Yichen Wu , Yair Rivenson , Alborz Feizi , Aydogan Ozcan

A single-pixel digital holography system with phase-encoded illumination using a digital micromirror device (DMD) as a spatial light modulator (SLM) is presented. The enhanced switching rate of DMDs, far exceeding the stringent frame-rate…

We introduce a new parallelized approach to photothermal microscopy that utilizes mid-infrared dual-comb lasers, enabling simultaneous measurements at hundreds of wavelengths. This technology allows for high-speed, label-free chemical…

Single Pixel (SP) imaging is now a reality in many applications, e.g., biomedical ultrathin endoscope and fluorescent spectroscopy. In this context, many schemes exist to improve the light throughput of these device, e.g., using structured…

Computer Vision and Pattern Recognition · Computer Science 2019-02-19 Amirafshar Moshtaghpour , José M. Bioucas-Dias , Laurent Jacques

Fluorescent observation of cells generally suffers from the limited axial resolution due to the elongated point spread function of the microscope optics. Consequently, three-dimensional imaging results in axial resolution being several…

Driven by many applications in a wide span of scientific fields, a myriad of advanced ultrafastimaging techniques have emerged in the last decade, featuring record-high imaging speeds abovea trillion-frame-per-second with long sequence…

Spatial Fluorescence Cross Correlation Spectroscopy is a rarely investigated version of Fluorescence Correlation Spectroscopy, in which the fluorescence signals from different observation volumes are cross-correlated. In the reported…

Optics · Physics 2008-06-13 Yoann Blancquaert , Jie Gao , Jacques Derouard , Antoine Delon

In this paper, we describe the principle of a multi-aperture interferometer that uses a phase-shifting technique and is suitable for quick, snapshot imaging of astrophysical objects at extreme angular resolution through Fourier inversion. A…

Optics · Physics 2015-05-28 Francois Henault

Fluorescence lifetime imaging microscopy (FLIM) is an important technique to understand the chemical micro-environment in cells and tissues since it provides additional contrast compared to conventional fluorescence imaging. When two…

Image and Video Processing · Electrical Eng. & Systems 2022-01-19 Varun Mannam , Xiaotong Yuan , Scott Howard

Tracking single fluorescent molecules has offered resolution into dynamic molecular processes at the single-molecule level. This perspective traces the evolution of single-molecule tracking, highlighting key developments across various…

Biological Physics · Physics 2026-02-24 Lance W. Q. Xu , Steve Pressé

Endoscopic optical imaging using a single multimode fiber (MMF) has emerged as a promising approach for highly compact, minimally invasive, and high-resolution imaging. Unlike conventional fiber bundles, MMF-based endomicroscopes exploit…

Recent advances in the field of attosecond science hold the promise of tracking electronic processes at the shortest space and time scales. Imaging methods that combine attosecond temporal with nanometer spatial resolution are currently out…

Single-pixel imaging, with the advantages of a wide spectrum, beyond-visual-field imaging, and robustness to light scattering, has attracted increasing attention in recent years. Fourier single-pixel imaging (FSI) can reconstruct sharp…

Image and Video Processing · Electrical Eng. & Systems 2021-08-05 Dong Zhou , Jie Cao , Huan Cui , Qun Hao , Bing-Kun Chen , Kai Lin

Microscopes face a trade-off between spatial resolution, field-of-view, and frame rate -- improving one of these properties typically requires sacrificing the others, due to the limited spatiotemporal throughput of the sensor. To overcome…

Light-field imaging is an emerging paradigm in biomedical optics, offering the unique ability to capture volumetric information in a single snapshot by encoding both the spatial and angular components of light. Unlike conventional…

Optics · Physics 2025-09-30 Ruixuan Zhao , Xuanwen Hua , Woongjae Baek , Zhaoqiang Wang , Shu Jia , Liang Gao

Ultrafast single-shot imaging techniques now reach frame rates of tens of tera-frame-per-second (Tfps) and long sequence depths but are often too complex for large-scale use, both in terms of image acquisition and reconstruction. We propose…

This paper introduces a single-pixel HyperSpectral (HS) imaging framework based on Fourier Transform Interferometry (FTI). By combining a space-time coding of the light illumination with partial interferometric observations of a collimated…

Computer Vision and Pattern Recognition · Computer Science 2018-09-05 Amirafshar Moshtaghpour , José M. Bioucas-Dias , Laurent Jacques

We discuss the spontaneous emission from a coherently prepared and microwave driven doublet of potentially closely spaced excited states to a common ground level. Multiple interference mechanisms are identified which may lead to…

Quantum Physics · Physics 2009-10-31 E. Paspalakis , C. H. Keitel , P. L. Knight
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