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The increasing demand for mental health services has outpaced the availability of real training data to develop clinical professionals, leading to limited support for the diagnosis of depression. This shortage has motivated the development…

Computation and Language · Computer Science 2025-08-07 Xi Wang , Anxo Perez , Javier Parapar , Fabio Crestani

Large Language Models (LLMs) have shown impressive potential to simulate human behavior. We identify a fundamental challenge in using them to simulate experiments: when LLM-simulated subjects are blind to the experimental design (as is…

Artificial Intelligence · Computer Science 2025-11-25 George Gui , Olivier Toubia

Despite the impressive capabilities of Large Language Models (LLMs), existing Conversational Health Agents (CHAs) remain static and brittle, incapable of adaptive multi-turn reasoning, symptom clarification, or transparent decision-making.…

Computation and Language · Computer Science 2025-07-11 Xinyi Liu , Dachun Sun , Yi R. Fung , Dilek Hakkani-Tür , Tarek Abdelzaher

Objective: This paper introduces a patient simulator for scalable, automated evaluation of healthcare conversational agents, generating realistic, controllable interactions that systematically vary across medical, linguistic, and behavioral…

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

Effective patient-provider communication is crucial in clinical care, directly impacting patient outcomes and quality of life. Traditional evaluation methods, such as human ratings, patient feedback, and provider self-assessments, are often…

Computation and Language · Computer Science 2024-09-25 Zhiyuan Wang , Fangxu Yuan , Virginia LeBaron , Tabor Flickinger , Laura E. Barnes

Large language models (LLMs) show potential as simulators of human behavior, offering a scalable way to study responses to interventions. However, because LLMs are trained largely on observational data, interventions in experiments with…

Computation and Language · Computer Science 2026-05-21 Victoria Lin , Taedong Yun , Maja Matarić , John Canny , Arthur Gretton , Alexander D'Amour

Agent-based modelling and simulation offers a new and exciting way of understanding the world of work. In this paper we describe the development of an agent-based simulation model, designed to help to understand the relationship between…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Peer-Olaf Siebers , Uwe Aickelin , Helen Celia , Christopher Clegg

Enhancing interrogation capabilities in Traditional Chinese Medicine (TCM) diagnosis through multi-turn dialogues and knowledge graphs presents a significant challenge for modern AI systems. Current large language models (LLMs), despite…

Artificial Intelligence · Computer Science 2025-07-08 Zewen Sun , Ruoxiang Huang , Jiahe Feng , Rundong Kong , Yuqian Wang , Hengyu Liu , Ziqi Gong , Yuyuan Qin , Yingxue Wang , Yu Wang

Advances in large language models (LLMs) enable many new innovations in education. However, evaluating the effectiveness of new technology requires real students, which is time-consuming and hard to scale up. Therefore, many recent works on…

Computation and Language · Computer Science 2026-05-06 Alexander Scarlatos , Jaewook Lee , Simon Woodhead , Andrew Lan

Clinical diagnosis begins with doctor-patient interaction, during which physicians iteratively gather information, determine examination and refine differential diagnosis through patients' response. This dynamic clinical-reasoning process…

Computation and Language · Computer Science 2025-12-30 Yuqi Tang , Jing Yu , Zichang Su , Kehua Feng , Zhihui Zhu , Libin Wang , Lei Liang , Qiang Zhang , Keyan Ding , Huajun Chen

Training dialog policies for speech-based virtual assistants requires a plethora of conversational data. The data collection phase is often expensive and time consuming due to human involvement. To address this issue, a common solution is…

Computation and Language · Computer Science 2019-11-11 Maryam Fazel-Zarandi , Longshaokan Wang , Aditya Tiwari , Spyros Matsoukas

Simulation models often have parameters as input and return outputs to understand the behavior of complex systems. Calibration is the process of estimating the values of the parameters in a simulation model in light of observed data from…

Methodology · Statistics 2024-11-15 Özge Sürer

Clinical decision-making is inherently complex, often influenced by cognitive biases, incomplete information, and case ambiguity. Large Language Models (LLMs) have shown promise as tools for supporting clinical decision-making, yet their…

Machine Learning · Computer Science 2025-07-10 Burcu Sayin , Ipek Baris Schlicht , Ngoc Vo Hong , Sara Allievi , Jacopo Staiano , Pasquale Minervini , Andrea Passerini

In conversational search, agents can interact with users by asking clarifying questions to increase their chance to find better results. Many recent works and shared tasks in both NLP and IR communities have focused on identifying the need…

Information Retrieval · Computer Science 2022-01-04 Zhenduo Wang , Qingyao Ai

People increasingly hold sustained, open-ended conversations with large language models (LLMs). Public reports and early studies suggest that, in such settings, models can reinforce delusional or conspiratorial ideation or even amplify…

Human-Computer Interaction · Computer Science 2026-04-09 Peter Kirgis , Ben Hawriluk , Sherrie Feng , Aslan Bilimer , Sam Paech , Zeynep Tufekci

Large language models (LLMs) are increasingly explored for clinical decision support, yet most evaluations are conducted in English, leaving their reliability in other languages uncertain. Here we evaluate the impact of prompting language…

Computation and Language · Computer Science 2026-05-20 Adrien Bazoge , Josselin Corvellec , Sofiane Djillali Sid-Ahmed , Pierre-Antoine Gourraud

Artificial intelligence has significantly advanced healthcare, particularly through large language models (LLMs) that excel in medical question answering benchmarks. However, their real-world clinical application remains limited due to the…

Computation and Language · Computer Science 2024-07-01 Zhihao Fan , Jialong Tang , Wei Chen , Siyuan Wang , Zhongyu Wei , Jun Xi , Fei Huang , Jingren Zhou

Large Language Models (LLMs) have demonstrated great potential for conducting diagnostic conversations but evaluation has been largely limited to language-only interactions, deviating from the real-world requirements of remote care…

We argue that enabling human-AI dialogue, purposed to support joint reasoning (i.e., 'inquiry'), is important for ensuring that AI decision making is aligned with human values and preferences. In particular, we point to logic-based models…

Artificial Intelligence · Computer Science 2024-05-29 Elfia Bezou-Vrakatseli , Oana Cocarascu , Sanjay Modgil