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In this paper, we review the new method Physics-Informed Neural Networks (PINNs) that has become the main pillar in scientific machine learning, we present recent practical extensions, and provide a specific example in data-driven discovery…

Machine Learning · Computer Science 2024-09-02 Maziar Raissi , Paris Perdikaris , Nazanin Ahmadi , George Em Karniadakis

One of the main goals of developmental biology is to reveal the gene regulatory networks (GRNs) underlying the robust differentiation of multipotent progenitors into precisely specified cell types. Most existing methods to infer GRNs from…

Quantitative Methods · Quantitative Biology 2024-01-23 Maria Mircea , Diego Garlaschelli , Stefan Semrau

Physics-Informed Neural Networks (PINNs) solve physical systems by incorporating governing partial differential equations directly into neural network training. In electromagnetism, where well-established methodologies such as FDTD and FEM…

Computational Physics · Physics 2026-02-13 Nilufer K. Bulut

This study presents a novel physics-informed neural network (PINN) framework for modeling poroelasticity in heterogeneous media with material interfaces. The approach introduces a composite neural network (CoNN) where separate neural…

Systems and Control · Electrical Eng. & Systems 2024-12-31 Sumanta Roy , Chandrasekhar Annavarapu , Pratanu Roy , Dakshina Murthy Valiveti

As a typical application of deep learning, physics-informed neural network (PINN) {has been} successfully used to find numerical solutions of partial differential equations (PDEs), but how to improve the limited accuracy is still a great…

Machine Learning · Computer Science 2022-08-09 Zhi-Yong Zhang , Hui Zhang , Li-Sheng Zhang , Lei-Lei Guo

Although physics-informed neural networks(PINNs) have progressed a lot in many real applications recently, there remains problems to be further studied, such as achieving more accurate results, taking less training time, and quantifying the…

Machine Learning · Computer Science 2022-12-01 Bin Shan , Ye Li , Shengjun Huang

In recent years, Scientific Machine Learning (SciML) methods for solving partial differential equations (PDEs) have gained increasing popularity. Within such a paradigm, Physics-Informed Neural Networks (PINNs) are novel deep learning…

Numerical Analysis · Mathematics 2024-04-25 Pasquale Ambrosio , Salvatore Cuomo , Mariapia De Rosa

State estimation is the cornerstone of the power system control center since it provides the operating condition of the system in consecutive time intervals. This work investigates the application of physics-informed neural networks (PINNs)…

Machine Learning · Computer Science 2026-04-07 Solon Falas , Markos Asprou , Charalambos Konstantinou , Maria K. Michael

Pharmacometric models are pivotal across drug discovery and development, playing a decisive role in determining the progression of candidate molecules. However, the derivation of mathematical equations governing the system is a…

Machine Learning · Computer Science 2024-05-02 Imran Nasim , Adam Nasim

Physics-Informed Neural Networks (PINN) are a machine learning tool that can be used to solve direct and inverse problems related to models described by Partial Differential Equations. This paper proposes an adaptive inverse PINN applied to…

Numerical Analysis · Mathematics 2024-11-28 Marco Berardi , Fabio Difonzo , Matteo Icardi

We propose a novel approach that integrates machine learning into compartmental disease modeling to predict the progression of COVID-19. Our model is explainable by design as it explicitly shows how different compartments evolve and it uses…

Mathematical models in neural networks are powerful tools for solving complex differential equations and optimizing their parameters; that is, solving the forward and inverse problems, respectively. A forward problem predicts the output of…

Machine Learning · Computer Science 2025-07-29 Aarush Gupta , Kendric Hsu , Syna Mathod

Pandemic(epidemic) modeling, aiming at disease spreading analysis, has always been a popular research topic especially following the outbreak of COVID-19 in 2019. Some representative models including SIR-based deep learning prediction…

Machine Learning · Computer Science 2022-12-07 Danfeng Guo , Zijie Huang , Junheng Hao , Yizhou Sun , Wei Wang , Demetri Terzopoulos

Physics-informed machine learning (PIML) is emerging as a potentially transformative paradigm for modeling complex biomedical systems by integrating parameterized physical laws with data-driven methods. Here, we review three main classes of…

Machine Learning · Computer Science 2025-10-08 Nazanin Ahmadi , Qianying Cao , Jay D. Humphrey , George Em Karniadakis

Physics-informed neural networks (PINNs) are at the forefront of scientific machine learning, making possible the creation of machine intelligence that is cognizant of physical laws and able to accurately simulate them. However, today's…

Neural and Evolutionary Computing · Computer Science 2026-02-23 Jian Cheng Wong , Chin Chun Ooi , Abhishek Gupta , Pao-Hsiung Chiu , Joshua Shao Zheng Low , My Ha Dao , Yew-Soon Ong

Physics-informed neural networks (PINNs) have great potential for flexibility and effectiveness in forward modeling and inversion of seismic waves. However, coordinate-based neural networks (NNs) commonly suffer from the "spectral bias"…

Geophysics · Physics 2025-06-19 Yi Ding , Su Chen , Hiroe Miyake , Xiaojun Li

We introduce an optimized physics-informed neural network (PINN) trained to solve the problem of identifying and characterizing a surface breaking crack in a metal plate. PINNs are neural networks that can combine data and physics in the…

Machine Learning · Computer Science 2020-05-09 Khemraj Shukla , Patricio Clark Di Leoni , James Blackshire , Daniel Sparkman , George Em Karniadakis

We demonstrate a Physics-informed Neural Network (PINN) based model for real-time health monitoring of a heat exchanger, that plays a critical role in improving energy efficiency of thermal power plants. A hypernetwork based approach is…

Machine Learning · Computer Science 2022-12-21 Ritam Majumdar , Vishal Jadhav , Anirudh Deodhar , Shirish Karande , Lovekesh Vig , Venkataramana Runkana

Physics-informed neural networks (PINNs) offer a powerful framework for seismic wavefield modeling, yet they typically require time-consuming retraining when applied to different velocity models. Moreover, their training can suffer from…

Geophysics · Physics 2025-06-03 Shijun Cheng , Tariq Alkhalifah

Physics-Informed Neural Networks (PINNs) have recently emerged as a novel approach to simulate complex physical systems on the basis of both data observations and physical models. In this work, we investigate the use of PINNs for various…

Analysis of PDEs · Mathematics 2024-03-27 Guillaume Coulaud , Maxime Le , Régis Duvigneau
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