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Motivation: Gene selection has become a common task in most gene expression studies. The objective of such research is often to identify the smallest possible set of genes that can still achieve good predictive performance. The problem of…

This study proposes a novel, integrative framework for patient-centered data science in the digital health era. We developed a multidimensional model that combines traditional clinical data with patient-reported outcomes, social…

Machine Learning · Computer Science 2024-08-07 Mohsen Amoei , Dan Poenaru

Many practical applications of AI in medicine consist of semi-supervised discovery: The investigator aims to identify features of interest at a resolution more fine-grained than that of the available human labels. This is often the scenario…

Computation and Language · Computer Science 2020-04-08 Allen Schmaltz , Andrew Beam

Prognostic and diagnostic AI-based medical devices hold immense promise for advancing healthcare, yet their rapid development has outpaced the establishment of appropriate validation methods. Existing approaches often fall short in…

Machine Learning · Computer Science 2024-09-10 Florian Hellmeier , Kay Brosien , Carsten Eickhoff , Alexander Meyer

Multistate process data are common in studies of chronic diseases such as cancer. These data are ideal for precision medicine purposes as they can be leveraged to improve more refined health outcomes, compared to standard survival outcomes,…

Methodology · Statistics 2022-11-28 Giorgos Bakoyannis

High dimensional statistical problems arise from diverse fields of scientific research and technological development. Variable selection plays a pivotal role in contemporary statistical learning and scientific discoveries. The traditional…

Statistics Theory · Mathematics 2009-10-08 Jianqing Fan , Jinchi Lv

Despite of various similar features, Functional Data Analysis and High-Dimensional Data Analysis are two major fields in Statistics that grew up recently almost independently one from each other. The aim of this paper is to propose a survey…

Methodology · Statistics 2024-01-29 Germán Aneiros , Silvia Novo , Philippe Vieu

How to select variables and identify functional forms for continuous variables is a key concern when creating a multivariable model. Ad hoc 'traditional' approaches to variable selection have been in use for at least 50 years. Similarly,…

Incorporating feature selection into a classification or regression method often carries a number of advantages. In this paper we formalize feature selection specifically from a discriminative perspective of improving…

Machine Learning · Computer Science 2013-01-18 Tony S. Jebara , Tommi S. Jaakkola

In medical domain, data features often contain missing values. This can create serious bias in the predictive modeling. Typical standard data mining methods often produce poor performance measures. In this paper, we propose a new method to…

Machine Learning · Statistics 2015-03-24 Talayeh Razzaghi , Oleg Roderick , Ilya Safro , Nick Marko

This paper considers the problem of variable selection in regression models in the case of functional variables that may be mixed with other type of variables (scalar, multivariate, directional, etc.). Our proposal begins with a simple null…

We develop a variational Bayes approach for dynamic variable selection in high-dimensional regression models with time-varying parameters and predictors that exhibit a predefined group structure. Through comprehensive simulation studies, we…

Methodology · Statistics 2025-04-16 Nicolas Bianco , Mauro Bernardi , Daniele Bianchi

In this paper we present several novel efficient techniques and multidimensional data structures which can improve the decision making process in many domains. We consider online range aggregation, range selection and range weighted median…

Computational Geometry · Computer Science 2010-01-12 Madalina Ecaterina Andreica , Mugurel Ionut Andreica , Nicolae Cataniciu

Food authenticity studies are concerned with determining if food samples have been correctly labeled or not. Discriminant analysis methods are an integral part of the methodology for food authentication. Motivated by food authenticity…

Methodology · Statistics 2010-10-08 Thomas Brendan Murphy , Nema Dean , Adrian E. Raftery

In the big data era researchers face a series of problems. Even standard approaches/methodologies, like linear regression, can be difficult or problematic with huge volumes of data. Traditional approaches for regression in big datasets may…

Methodology · Statistics 2024-11-13 Vasilis Chasiotis , Dimitris Karlis

Intelligent test requires efficient and effective analysis of high-dimensional data in a large scale. Traditionally, the analysis is often conducted by human experts, but it is not scalable in the era of big data. To tackle this challenge,…

Machine Learning · Computer Science 2022-07-04 Yiwen Liao , Tianjie Ge , Raphaël Latty , Bin Yang

Variable selection for optimal treatment regime in a clinical trial or an observational study is getting more attention. Most existing variable selection techniques focused on selecting variables that are important for prediction, therefore…

Methodology · Statistics 2014-05-22 Ailin Fan , Wenbin Lu , Rui Song

Optimization is ubiquitous in our daily lives. In the past, (sub-)optimal solutions to any problem have been derived by trial and error, sheer luck, or the expertise of knowledgeable individuals. In our contemporary age, there thankfully…

Neural and Evolutionary Computing · Computer Science 2023-12-07 Raphael Patrick Prager

Efficient sampling in biomolecular simulations is critical for accurately capturing the complex dynamical behaviors of biological systems. Adaptive sampling techniques aim to improve efficiency by focusing computational resources on the…

Biomolecules · Quantitative Biology 2024-10-22 Hassan Nadeem , Diwakar Shukla

Fueled by breakthrough technology developments, the biological, biomedical, and behavioral sciences are now collecting more data than ever before. There is a critical need for time- and cost-efficient strategies to analyze and interpret…