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This paper reported a bespoke adder-based deep learning network for time-domain fluorescence lifetime imaging (FLIM). By leveraging the l1-norm extraction method, we propose a 1-D Fluorescence Lifetime AdderNet (FLAN) without…

Signal Processing · Electrical Eng. & Systems 2022-09-13 Zhenya Zang , Dong Xiao , Quan Wang , Ziao Jiao , Chen Yu , David Day-Uei Li

We propose a method to facilitate exploration and analysis of new large data sets. In particular, we give an unsupervised deep learning approach to learning a latent representation that captures semantic similarity in the data set. The core…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Gary B Huang , Huei-Fang Yang , Shin-ya Takemura , Pat Rivlin , Stephen M Plaza

Deep learning has emerged as a technique of choice for rapid feature extraction across imaging disciplines, allowing rapid conversion of the data streams to spatial or spatiotemporal arrays of features of interest. However, applications of…

Data Analysis, Statistics and Probability · Physics 2021-01-25 Ayana Ghosh , Bobby G. Sumpter , Ondrej Dyck , Sergei V. Kalinin , Maxim Ziatdinov

Medical imaging plays a vital role in modern diagnostics; however, interpreting high-resolution radiological data remains time-consuming and susceptible to variability among clinicians. Traditional image processing techniques often lack the…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Melika Filvantorkaman , Maral Filvan Torkaman

Semantic segmentation is an essential step for electron microscopy (EM) image analysis. Although supervised models have achieved significant progress, the need for labor intensive pixel-wise annotation is a major limitation. To complicate…

Computer Vision and Pattern Recognition · Computer Science 2021-01-11 Jiajin Yi , Zhimin Yuan , Jialin Peng

Deep learning techniques have shown great potential in medical image processing, particularly through accurate and reliable image segmentation on magnetic resonance imaging (MRI) scans or computed tomography (CT) scans, which allow the…

Image and Video Processing · Electrical Eng. & Systems 2022-05-10 Yang Liu , Ersi Zhang , Lulu Xu , Chufan Xiao , Xiaoyun Zhong , Lijin Lian , Fang Li , Bin Jiang , Yuhan Dong , Lan Ma , Qiming Huang , Ming Xu , Yongbing Zhang , Dongmei Yu , Chenggang Yan , Peiwu Qin

Computational models that predict cellular phenotypic responses to chemical and genetic perturbations can accelerate drug discovery by prioritizing therapeutic hypotheses and reducing costly wet-lab iteration. However, extracting…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Pin-Jui Huang , Yu-Hsuan Liao , SooHeon Kim , NoSeong Park , JongBae Park , DongMyung Shin

Deep learning as represented by the artificial deep neural networks (DNNs) has achieved great success in many important areas that deal with text, images, videos, graphs, and so on. However, the black-box nature of DNNs has become one of…

Machine Learning · Computer Science 2021-09-29 Fenglei Fan , Jinjun Xiong , Mengzhou Li , Ge Wang

Automated analysis of electron microscopy datasets poses multiple challenges, such as limitation in the size of the training dataset, variation in data distribution induced by variation in sample quality and experiment conditions, etc. It…

Materials Science · Physics 2022-09-07 Arun Baskaran , Yulin Lin , Jianguo Wen , Maria K. Y. Chan

Cryo-electron microscopy (cryo-EM) has revolutionized structural biology by enabling near-atomic-level visualization of biomolecular assemblies. However, the exponential growth in cryo-EM data throughput and complexity, coupled with diverse…

Quantitative Methods · Quantitative Biology 2026-02-25 Weining Fu , Kai Shu , Kui Xu , Qiangfeng Cliff Zhang

Visualizing the details of different cellular structures is of great importance to elucidate cellular functions. However, it is challenging to obtain high quality images of different structures directly due to complex cellular environments.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-01 Yi Liu , Hao Yuan , Zhengyang Wang , Shuiwang Ji

Artificial neural network (ANN) is a versatile tool to study the neural representation in the ventral visual stream, and the knowledge in neuroscience in return inspires ANN models to improve performance in the task. However, it is still…

Machine Learning · Computer Science 2022-06-13 Xuming Ran , Jie Zhang , Ziyuan Ye , Haiyan Wu , Qi Xu , Huihui Zhou , Quanying Liu

In intensive care units (ICUs), critically ill patients are monitored with electroencephalograms (EEGs) to prevent serious brain injury. The number of patients who can be monitored is constrained by the availability of trained physicians to…

Confocal laser endomicroscopy (CLE) is an advanced optical fluorescence technology undergoing assessment for applications in brain tumor surgery. Despite its promising potential, interpreting the unfamiliar gray tone images of fluorescent…

Computer Vision and Pattern Recognition · Computer Science 2018-08-21 Mohammadhassan Izadyyazdanabadi , Evgenii Belykh , Michael Mooney , Nikolay Martirosyan , Jennifer Eschbacher , Peter Nakaji , Mark C. Preul , Yezhou Yang

The study of interlayer similarity of multiplex networks helps to understand the intrinsic structure of complex systems, revealing how changes in one layer can propagate and affect others, thus enabling broad implications for…

Social and Information Networks · Computer Science 2025-05-13 Haoran Nan , Senquan Wang , Chun Ouyang , Yanchen Zhou , Weiwei Gu

Endoscopic ultrasound (EUS) imaging has a trade-off between resolution and penetration depth. By considering the in-vivo characteristics of human organs, it is necessary to provide clinicians with appropriate hardware specifications for…

Image and Video Processing · Electrical Eng. & Systems 2023-09-14 Hah Min Lew , Jae Seong Kim , Moon Hwan Lee , Jaegeun Park , Sangyeon Youn , Hee Man Kim , Jihun Kim , Jae Youn Hwang

Deep Neural Networks have often been called the black box because of the complex, deep architecture and non-transparency presented by the inner layers. There is a lack of trust to use Artificial Intelligence in critical and high-precision…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Frincy Clement , Ji Yang , Irene Cheng

Compressive sensing (CS) is an effective approach for fast Magnetic Resonance Imaging (MRI). It aims at reconstructing MR images from a small number of under-sampled data in k-space, and accelerating the data acquisition in MRI. To improve…

Computer Vision and Pattern Recognition · Computer Science 2017-05-22 Yan Yang , Jian Sun , Huibin Li , Zongben Xu

Detecting synaptic clefts is a crucial step to investigate the biological function of synapses. The volume electron microscopy (EM) allows the identification of synaptic clefts by photoing EM images with high resolution and fine details.…

Computer Vision and Pattern Recognition · Computer Science 2021-01-13 Yi Liu , Shuiwang Ji

Deep learning architectures based on convolutional neural networks tend to rely on continuous, smooth features. While this characteristics provides significant robustness and proves useful in many real-world tasks, it is strikingly…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Zuzanna Buchnajzer , Kacper Dobek , Stanisław Hapke , Daniel Jankowski , Krzysztof Krawiec