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Structural changes in main retinal blood vessels serve as critical biomarkers for the onset and progression of glaucoma. Identifying these vessels is vital for vascular modeling yet highly challenging. This paper proposes X-GAN, a…

Image and Video Processing · Electrical Eng. & Systems 2025-09-23 Cheng Huang , Weizheng Xie , Tsengdar J. Lee , Jui-Kai Wang , Karanjit Kooner , Ning Zhang , Jia Zhang

The morphological attributes of retinal vessels, such as length, width, tortuosity and branching pattern and angles, play an important role in diagnosis, screening, treatment, and evaluation of various cardiovascular and ophthalmologic…

Image and Video Processing · Electrical Eng. & Systems 2019-11-25 Zhengyuan Liu

Deep learning models in medical image analysis often struggle with generalizability across domains and demographic groups due to data heterogeneity and scarcity. Traditional augmentation improves robustness, but fails under substantial…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Sebastian Doerrich , Francesco Di Salvo , Jonas Alle , Christian Ledig

Single-source domain generalization (SDG) in medical image segmentation is a challenging yet essential task as domain shifts are quite common among clinical image datasets. Previous attempts most conduct global-only/random augmentation.…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Zixian Su , Kai Yao , Xi Yang , Qiufeng Wang , Jie Sun , Kaizhu Huang

Among the research efforts to segment the retinal vasculature from fundus images, deep learning models consistently achieve superior performance. However, this data-driven approach is very sensitive to domain shifts. For fundus images, such…

Image and Video Processing · Electrical Eng. & Systems 2023-07-04 Dewei Hu , Xing Yao , Jiacheng Wang , Yuankai K. Tao , Ipek Oguz

The generalization of deep neural networks to unknown domains is a major challenge despite their tremendous progress in recent years. For this reason, the dynamic area of domain generalization (DG) has emerged. In contrast to unsupervised…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Manuel Schwonberg , Hanno Gottschalk

This study evaluated generative methods to potentially mitigate AI bias when diagnosing diabetic retinopathy (DR) resulting from training data imbalance, or domain generalization which occurs when deep learning systems (DLS) face concepts…

Artificial Intelligence · Computer Science 2020-12-03 Philippe Burlina , Neil Joshi , William Paul , Katia D. Pacheco , Neil M. Bressler

Domain generalization is a technique aimed at enabling models to maintain high accuracy when applied to new environments or datasets (unseen domains) that differ from the datasets used in training. Generally, the accuracy of models trained…

Computer Vision and Pattern Recognition · Computer Science 2026-04-09 Reiji Saito , Kazuhiro Hotta

Deep learning models have become the dominant method for medical image segmentation. However, they often struggle to be generalisable to unknown tasks involving new anatomical structures, labels, or shapes. In these cases, the model needs…

Image and Video Processing · Electrical Eng. & Systems 2024-09-17 Jing Xu

The morphology of retinal blood vessels can indicate various diseases in the human body, and researchers have been working on automatic scanning and segmentation of retinal images to aid diagnosis. This project compares the performance of…

Image and Video Processing · Electrical Eng. & Systems 2023-03-20 Ifeyinwa Linda Anene , Yongmin Li

In this work, we utilize image segmentation to visually identify blood vessels in retinal examination images. This process is typically carried out manually. However, we can employ heuristic methods and machine learning to automate or at…

Image and Video Processing · Electrical Eng. & Systems 2023-09-01 João Henrique Pereira Machado , Gilson Adamczuk Oliveira , Érick Oliveira Rodrigues

Automatic segmentation of magnetic resonance (MR) images is crucial for morphological evaluation of the pediatric musculoskeletal system in clinical practice. However, the accuracy and generalization performance of individual segmentation…

Computer Vision and Pattern Recognition · Computer Science 2022-02-03 Arnaud Boutillon , Pierre-Henri Conze , Christelle Pons , Valérie Burdin , Bhushan Borotikar

A novel topological segmentation of retinal images represents blood vessels as connected regions in the continuous image plane, having shape-related analytic and geometric properties. This paper presents topological segmentation results…

Computational Geometry · Computer Science 2016-08-05 Martin Brooks

Retinal vascular segmentation, a widely researched topic in biomedical image processing, aims to reduce the workload of ophthalmologists in treating and detecting retinal disorders. Segmenting retinal vessels presents unique challenges;…

Image and Video Processing · Electrical Eng. & Systems 2025-01-06 Melaku N. Getahun , Oleg Y. Rogov , Dmitry V. Dylov , Andrey Somov , Ahmed Bouridane , Rifat Hamoudi

In medical imaging, the heterogeneity of multi-centre data impedes the applicability of deep learning-based methods and results in significant performance degradation when applying models in an unseen data domain, e.g. a new centreor a new…

Computer Vision and Pattern Recognition · Computer Science 2020-08-12 Hongwei Li , Timo Loehr , Anjany Sekuboyina , Jianguo Zhang , Benedikt Wiestler , Bjoern Menze

Despite notable advancements, the integration of deep learning (DL) techniques into impactful clinical applications, particularly in the realm of digital histopathology, has been hindered by challenges associated with achieving robust…

Image and Video Processing · Electrical Eng. & Systems 2024-07-04 Sebastian Doerrich , Francesco Di Salvo , Christian Ledig

Vascular segmentation extracts blood vessels from images and serves as the basis for diagnosing various diseases, like ophthalmic diseases. Ophthalmologists often require high-resolution segmentation results for analysis, which leads to…

Image and Video Processing · Electrical Eng. & Systems 2022-07-29 Yan Hu , Zhongxi Qiu , Dan Zeng , Li Jiang , Chen Lin , Jiang Liu

Semantic segmentation of blood vessels is an important task in medical image analysis, but its progress is often hindered by the scarcity of large annotated datasets and the poor generalization of models across different imaging modalities.…

Computer Vision and Pattern Recognition · Computer Science 2025-11-03 Cesar H. Comin , Wesley N. Galvão

Histopathological images are essential for medical diagnosis and treatment planning, but interpreting them accurately using machine learning can be challenging due to variations in tissue preparation, staining and imaging protocols. Domain…

Computer Vision and Pattern Recognition · Computer Science 2023-11-01 Vaibhav Khamankar , Sutanu Bera , Saumik Bhattacharya , Debashis Sen , Prabir Kumar Biswas

Tight-frame, a generalization of orthogonal wavelets, has been used successfully in various problems in image processing, including inpainting, impulse noise removal, super-resolution image restoration, etc. Segmentation is the process of…

Numerical Analysis · Mathematics 2015-03-19 Xiaohao Cai , Raymond Chan , Serena Morigi , Fiorella Sgallari