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Automatic segmentation of neuronal topology is critical for handling large scale neuroimaging data, as it can greatly accelerate neuron annotation and analysis. However, the intricate morphology of neuronal branches and the occlusions among…

Image and Video Processing · Electrical Eng. & Systems 2025-08-01 Huayu Fu , Jiamin Li , Haozhi Qu , Xiaolin Hu , Zengcai Guo

In many biomedical segmentation tasks, the preservation of elongated structure continuity and length is more important than voxel-wise accuracy. We propose two novel loss functions, Negative Centerline Loss and Simplified Topology Loss,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Karol Szustakowski , Luk Frank , Julia Esser , Jan Gründemann , Marie Piraud

Developing automated and semi-automated solutions for reconstructing wiring diagrams of the brain from electron micrographs is important for advancing the field of connectomics. While the ultimate goal is to generate a graph of neuron…

Computer Vision and Pattern Recognition · Computer Science 2016-08-09 William Gray Roncal , Colin Lea , Akira Baruah , Gregory D. Hager

Electron microscopic connectomics is an ambitious research direction with the goal of studying comprehensive brain connectivity maps by using high-throughput, nano-scale microscopy. One of the main challenges in connectomics research is…

Computer Vision and Pattern Recognition · Computer Science 2021-04-14 Tran Minh Quan , David G. C. Hildebrand , Won-Ki Jeong

Reconstructing Portal Vein and Hepatic Vein trees from contrast enhanced abdominal CT scans is a prerequisite for preoperative liver surgery simulation. Existing deep learning based methods treat vascular tree reconstruction as a semantic…

Computer Vision and Pattern Recognition · Computer Science 2020-09-21 Deepak Keshwani , Yoshiro Kitamura , Satoshi Ihara , Satoshi Iizuka , Edgar Simo-Serra

Reconstruction of neuroanatomy is a fundamental problem in neuroscience. Stochastic expression of colors in individual cells is a promising tool, although its use in the nervous system has been limited due to various sources of variability…

Neurons and Cognition · Quantitative Biology 2017-01-24 Uygar Sümbül , Douglas Roussien , Fei Chen , Nicholas Barry , Edward S. Boyden , Dawen Cai , John P. Cunningham , Liam Paninski

Deep learning has been shown to produce state of the art results in many tasks in biomedical imaging, especially in segmentation. Moreover, segmentation of the cerebrovascular structure from magnetic resonance angiography is a challenging…

Computer Vision and Pattern Recognition · Computer Science 2018-12-06 Pedro Sanches , Cyril Meyer , Vincent Vigon , Benoît Naegel

Accurately segmenting thin tubular structures, such as vessels, nerves, roads or concrete cracks, is a crucial task in computer vision. Standard deep learning-based segmentation loss functions, such as Dice or Cross-Entropy, focus on…

Connectomics is an emerging field in neuroscience that aims to reconstruct the 3-dimensional morphology of neurons from electron microscopy (EM) images. Recent studies have successfully demonstrated the use of convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2017-02-27 Shibani Santurkar , David Budden , Alexander Matveev , Heather Berlin , Hayk Saribekyan , Yaron Meirovitch , Nir Shavit

In the field of Connectomics, a primary problem is that of 3D neuron segmentation. Although deep learning-based methods have achieved remarkable accuracy, errors still exist, especially in regions with image defects. One common type of…

Computer Vision and Pattern Recognition · Computer Science 2021-12-14 Jules Berman , Dmitri B. Chklovskii , Jingpeng Wu

The field of connectomics faces unprecedented "big data" challenges. To reconstruct neuronal connectivity, automated pixel-level segmentation is required for petabytes of streaming electron microscopy data. Existing algorithms provide…

Seeking effective neural networks is a critical and practical field in deep learning. Besides designing the depth, type of convolution, normalization, and nonlinearities, the topological connectivity of neural networks is also important.…

Computer Vision and Pattern Recognition · Computer Science 2020-08-20 Kun Yuan , Quanquan Li , Jing Shao , Junjie Yan

Blood vessel segmentation is one of the most studied topics in computer vision, due to its relevance in daily clinical practice. Despite the evolution the field has been facing, especially after the dawn of deep learning, important…

Image and Video Processing · Electrical Eng. & Systems 2021-08-02 R. J. Araújo , J. S. Cardoso , H. P. Oliveira

Automatic 3D neuron reconstruction is critical for analysing the morphology and functionality of neurons in brain circuit activities. However, the performance of existing tracing algorithms is hinged by the low image quality. Recently, a…

Image and Video Processing · Electrical Eng. & Systems 2021-09-17 Heng Wang , Chaoyi Zhang , Jianhui Yu , Yang Song , Siqi Liu , Wojciech Chrzanowski , Weidong Cai

Researchers in the field of connectomics are working to reconstruct a map of neural connections in the brain in order to understand at a fundamental level how the brain processes information. Constructing this wiring diagram is done by…

The exact shape of intracranial aneurysms is critical in medical diagnosis and surgical planning. While voxel-based deep learning frameworks have been proposed for this segmentation task, their performance remains limited. In this study, we…

Image and Video Processing · Electrical Eng. & Systems 2021-07-06 Xi Yang , Ding Xia , Taichi Kin , Takeo Igarashi

Volumetric brain reconstructions provide an unprecedented opportunity to gain insights into the complex connectivity patterns of neurons in an increasing number of organisms. Here, we model and quantify the complexity of the resulting…

Neurons and Cognition · Quantitative Biology 2024-05-13 Anastasiya Salova , István A. Kovács

Automatic instance segmentation is a problem that occurs in many biomedical applications. State-of-the-art approaches either perform semantic segmentation or refine object bounding boxes obtained from detection methods. Both suffer from…

Computer Vision and Pattern Recognition · Computer Science 2020-04-22 Long Chen , Martin Strauch , Dorit Merhof

Tree-like structures, such as blood vessels, often express complexity at very fine scales, requiring high-resolution grids to adequately describe their shape. Such sparse morphology can alternately be represented by locations of centreline…

Computer Vision and Pattern Recognition · Computer Science 2018-11-09 Kerry Halupka , Rahil Garnavi , Stephen Moore

The task of blood vessel segmentation in microscopy images is crucial for many diagnostic and research applications. However, vessels can look vastly different, depending on the transient imaging conditions, and collecting data for…

Image and Video Processing · Electrical Eng. & Systems 2019-08-19 Shir Gur , Lior Wolf , Lior Golgher , Pablo Blinder
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