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Tumor segmentation plays a critical role in histopathology, but it requires costly, fine-grained image-mask pairs annotated by pathologists. Thus, synthesizing histopathology data to expand the dataset is highly desirable. Previous works…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Hong Liu , Haosen Yang , Evi M. C. Huijben , Mark Schuiveling , Ruisheng Su , Josien P. W. Pluim , Mitko Veta

Semantic segmentation of electron microscopy (EM) images of biological samples remains a challenge in the life sciences. EM data captures details of biological structures, sometimes with such complexity that even human observers can find it…

Computer Vision and Pattern Recognition · Computer Science 2025-11-03 Sheida Rahnamai Kordasiabi , Damian Dalle Nogare , Florian Jug

In view of the fact that semi- and self-supervised learning share a fundamental principle, effectively modeling knowledge from unlabeled data, various semi-supervised semantic segmentation methods have integrated representative…

Computer Vision and Pattern Recognition · Computer Science 2024-11-15 Yangyang Li , Xuanting Hao , Ronghua Shang , Licheng Jiao

Semi-supervised learning has attracted much attention in medical image segmentation due to challenges in acquiring pixel-wise image annotations, which is a crucial step for building high-performance deep learning methods. Most existing…

Computer Vision and Pattern Recognition · Computer Science 2020-10-22 Shuailin Li , Chuyu Zhang , Xuming He

Digital histopathology whole slide images (WSIs) provide gigapixel-scale high-resolution images that are highly useful for disease diagnosis. However, digital histopathology image analysis faces significant challenges due to the limited…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Bodong Zhang , Xiwen Li , Hamid Manoochehri , Xiaoya Tang , Deepika Sirohi , Beatrice S. Knudsen , Tolga Tasdizen

Medical image segmentation methods are generally designed as fully-supervised to guarantee model performance, which require a significant amount of expert annotated samples that are high-cost and laborious. Semi-supervised image…

Computer Vision and Pattern Recognition · Computer Science 2023-10-10 Xiangyu Zhao , Zengxin Qi , Sheng Wang , Qian Wang , Xuehai Wu , Ying Mao , Lichi Zhang

This paper presents a novel semantic scene change detection scheme with only weak supervision. A straightforward approach for this task is to train a semantic change detection network directly from a large-scale dataset in an end-to-end…

Computer Vision and Pattern Recognition · Computer Science 2022-09-07 Ken Sakurada , Mikiya Shibuya , Weimin Wang

Medical image segmentation assists in computer-aided diagnosis, surgeries, and treatment. Digitize tissue slide images are used to analyze and segment glands, nuclei, and other biomarkers which are further used in computer-aided medical…

Image and Video Processing · Electrical Eng. & Systems 2022-09-05 Saad Wazir , Muhammad Moazam Fraz

Semi-supervised semantic segmentation involves assigning pixel-wise labels to unlabeled images at training time. This is useful in a wide range of real-world applications where collecting pixel-wise labels is not feasible in time or cost.…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Jianfeng Wang , Daniela Massiceti , Xiaolin Hu , Vladimir Pavlovic , Thomas Lukasiewicz

The Segment Anything Model (SAM) marks a significant advancement in segmentation models, offering robust zero-shot abilities and dynamic prompting. However, existing medical SAMs are not suitable for the multi-scale nature of whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hong Liu , Haosen Yang , Paul J. van Diest , Josien P. W. Pluim , Mitko Veta

Histopathological analysis is the present gold standard for precancerous lesion diagnosis. The goal of automated histopathological classification from digital images requires supervised training, which requires a large number of expert…

Image and Video Processing · Electrical Eng. & Systems 2021-11-15 Yuan Xue , Jiarong Ye , Qianying Zhou , Rodney Long , Sameer Antani , Zhiyun Xue , Carl Cornwell , Richard Zaino , Keith Cheng , Xiaolei Huang

In histopathology, tissue samples are often larger than a standard microscope slide, making stitching of multiple fragments necessary to process entire structures such as tumors. Automated stitching is a prerequisite for scaling analysis,…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Stefan Brandstätter , Maximilian Köller , Philipp Seeböck , Alissa Blessing , Felicitas Oberndorfer , Svitlana Pochepnia , Helmut Prosch , Georg Langs

Trained using only image class label, deep weakly supervised methods allow image classification and ROI segmentation for interpretability. Despite their success on natural images, they face several challenges over histology data where ROI…

Image and Video Processing · Electrical Eng. & Systems 2022-05-13 Soufiane Belharbi , Jérôme Rony , Jose Dolz , Ismail Ben Ayed , Luke McCaffrey , Eric Granger

Pseudo-normality synthesis, which computationally generates a pseudo-normal image from an abnormal one (e.g., with lesions), is critical in many perspectives, from lesion detection, data augmentation to clinical surgery suggestion. However,…

Computer Vision and Pattern Recognition · Computer Science 2021-06-30 Yuanqi Du , Quan Quan , Hu Han , S. Kevin Zhou

Segmentation is a critical task in computational pathology, as it identifies areas affected by disease or abnormal growth and is essential for diagnosis and treatment. However, acquiring high-quality pixel-level supervised segmentation data…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Zhiling Yan , Sicheng Chen , Tianyi Zhang , Nan Ying , Yanli Lei , Guanglei Zhang

Fibrotic Lung Disease (FLD) is a severe condition marked by lung stiffening and scarring, leading to respiratory decline. High-resolution computed tomography (HRCT) is critical for diagnosing and monitoring FLD; however, fibrosis appears as…

Image and Video Processing · Electrical Eng. & Systems 2025-06-23 Zhiling Yue , Yingying Fang , Liutao Yang , Nikhil Baid , Simon Walsh , Guang Yang

Training of semantic segmentation models for material analysis requires micrographs and their corresponding masks. It is quite unlikely that perfect masks will be drawn, especially at the edges of objects, and sometimes the amount of data…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Matias Oscar Volman Stern , Dominic Hohs , Andreas Jansche , Timo Bernthaler , Gerhard Schneider

The Segment Anything Model (SAM), a profound vision foundation model pretrained on a large-scale dataset, breaks the boundaries of general segmentation and sparks various downstream applications. This paper introduces Hi-SAM, a unified…

Computer Vision and Pattern Recognition · Computer Science 2024-11-11 Maoyuan Ye , Jing Zhang , Juhua Liu , Chenyu Liu , Baocai Yin , Cong Liu , Bo Du , Dacheng Tao

Semantic segmentation is a crucial task in biomedical image processing, which recent breakthroughs in deep learning have allowed to improve. However, deep learning methods in general are not yet widely used in practice since they require…

Computer Vision and Pattern Recognition · Computer Science 2019-07-12 Melanie Lubrano di Scandalea , Christian S. Perone , Mathieu Boudreau , Julien Cohen-Adad

Many computer vision systems require low-cost segmentation algorithms based on deep learning, either because of the enormous size of input images or limited computational budget. Common solutions uniformly downsample the input images to…

Computer Vision and Pattern Recognition · Computer Science 2022-08-19 Chen Jin , Ryutaro Tanno , Thomy Mertzanidou , Eleftheria Panagiotaki , Daniel C. Alexander