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Advanced microscopy techniques are essential in biomedical research for visualising and tracking biomolecules within living cells and their compartments. Conventional fluorescence microscopy methods, however, often struggle with accurately…

We present scanning tunneling microscopy (STM) images of single-layer graphene crystals examined under ultrahigh vacuum conditions. The samples, with lateral dimensions on the micron scale, were prepared on a silicon dioxide surface by…

Measuring subdiffraction separations between single fluorescent particles is important for biological, nano-, and medical-technology studies. Major challenges include (i) measuring changing molecular separations with high temporal…

Biological Physics · Physics 2015-05-18 Shawn H. DeCenzo , Michael C. DeSantis , Y. M. Wang

Single-molecule force spectroscopy (smFS) is a powerful approach to studying molecular self-organization. However, the coupling of the molecule with the ever-present experimental device introduces artifacts, that complicates the…

Chemical Physics · Physics 2023-04-25 Lars Dingeldein , Pilar Cossio , Roberto Covino

Microfabrication of graphene devices used in many experimental studies currently relies on the fact that graphene crystallites can be visualized using optical microscopy if prepared on top of silicon wafers with a certain thickness of…

Mesoscale and Nanoscale Physics · Physics 2007-09-22 P. Blake , K. S. Novoselov , A. H. Castro Neto , D. Jiang , R. Yang , T. J. Booth , A. K. Geim , E. W. Hill

Detecting trace molecules remains a significant challenge. Surface-enhanced infrared absorption (SEIRA) based on plasmonic nanostructures, particularly graphene, has emerged as a promising approach to enhance sensing sensitivity. While…

Research in semiconductor physics has advanced to the study of two-dimensional (2D) materials where the surface controls electronic transport. A scanning probe microscope (SPM) is an ideal tool to image electronic motion in these devices by…

Mesoscale and Nanoscale Physics · Physics 2017-02-01 Sagar Bhandari , Robert M. Westervelt

In this paper we show how single layer graphene can be utilized to study swift heavy ion (SHI) modifications on various substrates. The samples were prepared by mechanical exfoliation of bulk graphite onto SrTiO$_3$, NaCl and Si(111),…

Materials Science · Physics 2015-06-12 O. Ochedowski , S. Akcöltekin , B. Ban d`Etat , H. Lebius , M. Schleberger

The study of biomolecular folding has been greatly advanced by single-molecule force spectroscopy (SMFS), which enables the observation of the dynamics of individual molecules. However, extracting quantitative models of fundamental…

Chemical Physics · Physics 2026-04-30 Lars Dingeldein , Aaron Lyons , Pilar Cossio , Michael Woodside , Roberto Covino

Single molecule fluorescence microscopy is a powerful technique for uncovering detailed information about biological systems, both in vitro and in vivo. In such experiments, the inherently low signal to noise ratios mean that accurate…

Computer Vision and Pattern Recognition · Computer Science 2013-06-10 Ji Won Yoon

Recent works on salient object detection have made use of multi-scale features in a way such that high-level features and low-level features can collaborate in locating salient objects. Many of the previous methods have achieved great…

Computer Vision and Pattern Recognition · Computer Science 2022-11-15 Xiaogang Liu Shuang Song

Graphene is a truly two-dimensional material with exceptional electronic, mechanical, and optical properties. As such, it consists of surface only and can be probed by the well developed surface-science techniques as, e.g., scanning…

Mesoscale and Nanoscale Physics · Physics 2012-04-18 Markus Morgenstern

Background rejection is key to success for future neutrinoless double beta decay experiments. To achieve sensitivity to effective Majorana lifetimes of $\sim10^{28}$ years, backgrounds must be controlled to better than 0.1 count per ton per…

Instrumentation and Detectors · Physics 2016-09-22 B. J. P. Jones , A. D. McDonald , D. R. Nygren

Conventional cameras, such as in smartphones, capture wideband red, green and blue (RGB) spectral components, replicating human vision. Multispectral imaging (MSI) captures spatial and spectral information beyond our vision but typically…

Lensless illumination single-pixel imaging with a multicore fiber (MCF) is a computational imaging technique that enables potential endoscopic observations of biological samples at cellular scale. In this work, we show that this technique…

Signal Processing · Electrical Eng. & Systems 2023-07-18 Olivier Leblanc , Matthias Hofer , Siddharth Sivankutty , Hervé Rigneault , Laurent Jacques

Single-molecule detection enables direct observation of individual biomolecular events, providing mechanistic insights into biological processes and offering a powerful tool for disease diagnostics. However, the fundamental scale mismatch…

Optics · Physics 2025-10-14 Guifeng Li , Chaoyang Gong

We demonstrate that it is possible to mechanically exfoliate graphene under ultra high vacuum conditions on the atomically well defined surface of single crystalline silicon. The flakes are several hundred nanometers in lateral size and…

Materials Science · Physics 2015-06-05 O. Ochedowski , G. Begall , N. Scheuschner , M. El Kharrazi , J. Maultzsch , M. Schleberger

Graphene based sheets have stimulated great interest due to their superior mechanical, electrical and thermal properties. A general visualization method that allows quick observation of these single atomic layers would be highly desirable…

Materials Science · Physics 2009-12-15 Jaemyung Kim , Laura J. Cote , Franklin Kim , Jiaxing Huang

Because of the dominant role of the surface of molecules and their individuality, molecules behave dis-tinctively in a confined space, which has far-reaching implications in many physical, chemical and bio-logical systems. Here, we…

Mesoscale and Nanoscale Physics · Physics 2014-04-29 DaeEung Lee , Gwanghyun Ahn , Sunmin Ryu

The use of graphene in surface plasmon resonance sensors, covering a metallic (plasmonic) film, has a number of demonstrated advantages, such protecting the film against corrosion/oxidation and facilitating the introduction of functional…

Mesoscale and Nanoscale Physics · Physics 2022-10-26 Aline dos S. Almeida , D. A. Bahamon , Nuno M. R. Peres , Christiano J. S. de Matos
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