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The rapid advancement of medical technology has led to an exponential increase in multi-modal medical data, including imaging, genomics, and electronic health records (EHRs). Graph neural networks (GNNs) have been widely used to represent…

Quantitative Methods · Quantitative Biology 2024-10-03 Favour Nerrise , Alice Louise Heiman , Ehsan Adeli

Parkinsons disease (PD) is considered one of the most frequent neurological diseases in the world. There is a need to study the early and efficient biomarkers of Parkinsons, such as changes in structural disorders like DNA and chromatin,…

Parkinson's disease (PD) is a progressive neurological disorder that impacts the quality of life significantly, making in-home monitoring of motor symptoms such as Freezing of Gait (FoG) critical. However, existing symptom monitoring…

Machine Learning · Computer Science 2026-04-16 Shovito Barua Soumma , Daniel Peterson , Shyamal Mehta , Hassan Ghasemzadeh

Accurate diagnosis is crucial for preventing the progression of Parkinson's, as well as improving the quality of life with individuals with Parkinson's disease. In this paper, we develop a sex-specific and age-dependent classification…

Machine Learning · Computer Science 2020-01-01 Ujjwal Gupta , Hritik Bansal , Deepak Joshi

There is a growing interest in using pose estimation algorithms for video-based assessment of Bradykinesia in Parkinson's Disease (PD) to facilitate remote disease assessment and monitoring. However, the accuracy of pose estimation…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Gabriela T. Acevedo Trebbau , Andrea Bandini , Diego L. Guarin

Decoding motor performance from brain signals offers promising avenues for adaptive deep brain stimulation (aDBS) for Parkinson's disease (PD). In a two-center cohort of 19 PD patients executing a drawing task, we decoded motor performance…

In this work we propose a new biophysical computational model of brain regions relevant to Parkinson's Disease based on local field potential data collected from the brain of marmoset monkeys. Parkinson's disease is a neurodegenerative…

Parkinson's disease (PD) is projected to increase substantially due to population aging, making early diagnosis increasingly important, as timely detection may delay progression and reduce long-term complications. Retinal microvasculature…

Parkinson's Disease (PD) is a progressive neurodegenerative movement disorder that affects more that 6 million people worldwide. Motor dysfunction gradually increases as the disease progress. It is usually mild in the early stages of the…

Computers and Society · Computer Science 2015-11-12 Ioannis Pachoulakis , Nikolaos Papadopoulos , Cleanthe Spanaki

This paper presents a novel deep learning enabled, video based analysis framework for assessing the Unified Parkinsons Disease Rating Scale (UPDRS) that can be used in the clinic or at home. We report results from comparing the performance…

Computer Vision and Pattern Recognition · Computer Science 2021-04-13 Deval Mehta , Umar Asif , Tian Hao , Erhan Bilal , Stefan Von Cavallar , Stefan Harrer , Jeffrey Rogers

We present a web-based framework to screen for Parkinson's disease (PD) by allowing users to perform neurological tests in their homes. Our web framework guides the users to complete three tasks involving speech, facial expression, and…

Human-Computer Interaction · Computer Science 2023-11-22 Md Saiful Islam , Sangwu Lee , Abdelrahman Abdelkader , Sooyong Park , Ehsan Hoque

Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, yet there is no disease-modifying therapy up to this date. The biological complexity underlying PD hampers the investigation of the principal…

Dynamical Systems · Mathematics 2022-12-22 Elena Righetti , Alice Antonello , Luca Marchetti , Enrico Domenici , Federico Reali

Parkinson's disease (PD) poses challenges in diagnosis and monitoring due to its progressive nature and complex symptoms. This study introduces a novel approach utilizing surface electromyography (sEMG) to objectively assess PD severity,…

Background: Parkinson's disease remains a major neurodegenerative disorder with high misdiagnosis rates, primarily due to reliance on clinical rating scales. Recent studies have demonstrated a strong association between gut microbiota and…

Artificial Intelligence · Computer Science 2025-09-10 Bo Yu , Zhixiu Hua , Bo Zhao

Severity assessment of Parkinson's disease (PD) using wearable sensors offers an effective, objective basis for clinical management. However, general-purpose time series models often lack pathological specificity in feature extraction,…

Machine Learning · Computer Science 2025-10-14 Weiming Zhao , Xulong Wang , Jun Qi , Yun Yang , Po Yang

Wearable technology for the automatic detection of gait events has recently gained growing interest, enabling advanced analyses that were previously limited to specialist centres and equipment (e.g., instrumented walkway). In this study, we…

Signal Processing · Electrical Eng. & Systems 2020-09-01 Matteo Gadaleta , Giulia Cisotto , Michele Rossi , Rana Zia Ur Rehman , Lynn Rochester , Silvia Del Din

Parkinsons disease (PD) alters cortical neural dynamics, yet reliable non-invasive electrophysiological biomarkers remain elusive. This study examined whether interpretable EEG features capturing complementary aspects of neural dynamics can…

Neurons and Cognition · Quantitative Biology 2026-04-14 Antonios G. Dougalis

Speech disorders often occur at the early stage of Parkinson's disease (PD). The speech impairments could be indicators of the disorder for early diagnosis, while motor symptoms are not obvious. In this study, we constructed a new speech…

Audio and Speech Processing · Electrical Eng. & Systems 2021-06-01 Hao Fang , Chen Gong , Chen Zhang , Yanan Sui , Luming Li

Alzheimer's disease is one of the most incisive illnesses among the neurodegenerative ones, and it causes a progressive decline in cognitive abilities that, in the worst cases, becomes severe enough to interfere with daily life. Currently,…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Tiziana D'Alessandro , Cristina Carmona-Duarte , Claudio De Stefano , Moises Diaz , Miguel A. Ferrer , Francesco Fontanella

In this paper, by characterizing the Leg Agility (LA) task, which contributes to the evaluation of the degree of severity of the Parkinson's Disease (PD), through kinematic variables (including the angular amplitude and speed of thighs'…

Computers and Society · Computer Science 2015-02-16 Matteo Giuberti , Gianluigi Ferrari , Laura Contin , Veronica Cimolin , Corrado Azzaro , Giovanni Albani , Alessandro Mauro
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